The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Early myotome specification regulates PDGFA expression and axial skeleton development
Abstract
Reciprocal defects in signaling between the myotome and the sclerotome compartments of the somites in PDGFRαand Myf5 mutant embryos lead to alterations in the formation of the vertebrae and the ribs. To investigate the significance of these observations, we have examined the role of PDGF signaling in the developing somite. PDGFA ligand expression was not detected in the myotome of Myf5 null mutant embryos and PDGFA promoter activity was regulated by Myf5 in vitro. PDGFA stimulated chondrogenesis in somite micromass cultures as well as in embryos when PDGFA was knocked into the Myf5 locus, resulting in increased vertebral and rib development. PDGFA expression in the myotome was fully restored in embryos in which MyoD has been introduced at the Myf5 locus but to a lesser extent in similar myogenin knock-in embryos. These results underscore the importance of growth factor signaling within the developing somite and suggest an important role for myogenic determination factors in orchestrating normal development of the axial skeleton.
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Citations
Cites
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
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PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
Kassar-Duchossoy, L., Gayraud-Morel, B., Gomès, D., Rocancourt, D., Buckingham, M., Shinin, V., & Tajbakhsh, S. (2004) · Nature · doi:10.1038/nature02876 · Cited by 677
Roles of PDGF in animal development
Hoch, R. V., & Soriano, P. (2003) · Development · doi:10.1242/dev.00721 · Cited by 585
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Metadata
- Authors
- Tallquist, M. D., Weismann, K. E., Hellström, M., & Soriano, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-12-01
- Volume
- 127
- Issue
- 23
- Pages
- 5059-5070
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1943069338
- Cited by
- 260
- References
- 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tallquist, M. D., Weismann, K. E., Hellström, M., & Soriano, P. (2000). Early myotome specification regulates PDGFA expression and axial skeleton development. Development. https://doi.org/10.1242/dev.127.23.5059
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