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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas
Open accessAbstract
Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6.1 in mice leads to loss of β-cell precursors and blocks β-cell neogenesis specifically during the secondary transition. In contrast, islet development in Nkx6.1/Nkx2.2 double mutant embryos is identical to Nkx2.2 single mutant islet development: β-cell precursors survive but fail to differentiate into β-cells throughout development. Together, these experiments reveal two independently controlled pathways for β-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of β-cell differentiation.
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Citations
Cited by
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
Notch signaling controls multiple steps of pancreatic differentiation
Murtaugh, L. C., Stanger, B. Z., Kwan, K. M., & Melton, D. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436557100 · Cited by 782
Opposing actions of Arx and Pax4 in endocrine pancreas development
Collombat, P., Mansouri, A., Hecksher-Sørensen, J., Serup, P., Krull, J., Gradwohl, G., & Gruss, P. (2003) · Genes & Development · doi:10.1101/gad.269003 · Cited by 600
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, P. A., Freude, K. K., Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G., & Sander, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609217104 · Cited by 567
Self-citationA Multipotent Progenitor Domain Guides Pancreatic Organogenesis
Zhou, Q., Law, A. C., Rajagopal, J., Anderson, W. J., Gray, P. A., & Melton, D. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.06.001 · Cited by 537
Metadata
- Authors
- Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Cruz, F. D., Schwitzgebel, V., Hayes-Jordan, A., & German, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-12-15
- Volume
- 127
- Issue
- 24
- Pages
- 5533-5540
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2223979714
- Cited by
- 520
- References
- 0
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. https://app.cochat.ai/papers/10.1242/dev.127.24.5533
- The paper
- Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Cruz, F. D., Schwitzgebel, V., Hayes-Jordan, A., & German, M. (2000). Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. Development. https://doi.org/10.1242/dev.127.24.5533
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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