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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas
Open accessAbstract
Most insulin-producing β-cells in the fetal mouse pancreas arise during the secondary transition, a wave of differentiation starting at embryonic day 13. Here, we show that disruption of homeobox gene Nkx6.1 in mice leads to loss of β-cell precursors and blocks β-cell neogenesis specifically during the secondary transition. In contrast, islet development in Nkx6.1/Nkx2.2 double mutant embryos is identical to Nkx2.2 single mutant islet development: β-cell precursors survive but fail to differentiate into β-cells throughout development. Together, these experiments reveal two independently controlled pathways for β-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of β-cell differentiation.
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Metadata
- Authors
- Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Cruz, F. D., Schwitzgebel, V., Hayes-Jordan, A., & German, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-12-15
- Volume
- 127
- Issue
- 24
- Pages
- 5533-5540
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2223979714
- Cited by
- 520
- References
- 0
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- green
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