Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo
Abstract
Dorsal-ventral polarity of the Drosophila embryo is established by a nuclear gradient of Dorsal protein, generated by successive gurken-Egfr and spätzle-Toll signaling. Overexpression of extracellular Spätzle dramatically reshapes the Dorsal gradient: the normal single peak is broadened and then refined to two distinct peaks of nuclear Dorsal, to produce two ventral furrows. This partial axis duplication, which mimics the ventralized phenotype caused by reduced gurken-Egfr signaling, arises from events in the perivitelline fluid of the embryo and occurs at the level of Spätzle processing or Toll activation. The production of two Dorsal peaks is addressed by a model that invokes action of a diffusible inhibitor, which is proposed to normally regulate the slope of the Dorsal gradient.
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The protease reactions occur in the perivitelline space and culminate in the processing of Spatzle, the protein ligand for Toll.
“The protease reactions occur in the perivitelline space and culminate in the processing of Spa ¨tzle (Spz), the protein ligand for Toll”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Morisato 2001
Cites
Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E. (1994) · Genes & Development · doi:10.1101/gad.8.21.2602 · Cited by 308 · see citing works
Bergmann, A., Stein, D., Geisler, R., Hagenmaier, S., Schmid, B., Fernandez, N., Schnell, B., & Nüsslein-Volhard, C. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00607-7 · Cited by 119 · see citing works
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Graded dorsal and differential gene regulation in the Drosophila embryo.
Reeves, G. T., & Stathopoulos, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000836 · Cited by 119 · see citing works
The origin of dorsoventral polarity in <i>Drosophila</i>
Roth, S. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2003.1325 · Cited by 87 · see citing works
- Authors
- Morisato, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Morisato, Donald
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-06-15
- Volume
- 128
- Issue
- 12
- Pages
- 2309-2319
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2169024586
- Cited by
- 46
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm052084-05)
- National Institute of General Medical Sciences (GM 52084)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Spätzle, Drosophila embryo, dorsal-ventral polarity, Toll signaling, axis duplication, perivitelline fluid, nuclear gradients
- MeSH terms
- Animals, Drosophila melanogaster, Female, Membrane Glycoproteins, Oogenesis, Receptors, Cell Surface, Sulfotransferases, Transforming Growth Factors, Signal Transduction, Gene Expression Regulation, Enzymologic, Transforming Growth Factor alpha, Gene Expression Regulation, Developmental, Insect Proteins, Body Patterning, Drosophila Proteins, Toll-Like Receptors, ErbB Receptors
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