The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development
Open accessAbstract
A key factor in the genetically programmed development of the nervous system is the death of massive numbers of neurons. Therefore, genetic mechanisms governing cell survival are of fundamental importance to developmental neuroscience. We report that inner ear sensory neurons are dependent on a basic helix-loop-helix transcription factor called NeuroD for survival during differentiation. Mice lacking NeuroD protein exhibit no auditory evoked potentials, reflecting a profound deafness. DiI fiber staining, immunostaining and cell death assays reveal that the deafness is due to the failure of inner ear sensory neuron survival during development. The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting that the ability of NeuroD to support neuronal survival may be directly mediated through regulation of responsiveness to the neurotrophins.
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Cites
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Self-citation
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Self-citationSmaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
Matei, V., Pauley, S., Kaing, S., Rowitch, D., Beisel, K. W., Morris, K., Feng, F., Jones, K., Lee, J., & Fritzsch, B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20551 · Cited by 435
Self-citationThe role of Six1 in mammalian auditory system development
Zheng, W., Huang, L., Wei, Z.-B., Silvius, D., Tang, B., & Xu, P.-X. (2003) · Development · doi:10.1242/dev.00628 · Cited by 333
Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression
Fariñas, I., Jones, K. R., Tessarollo, L., Vigers, A. J., Huang, E., Kirstein, M., de Caprona, D. C., Coppola, V., Backus, C., Reichardt, L. F., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06170.2001 · Cited by 288
Self-citationRevisiting cell fate specification in the inner ear
Fekete, D. M., & Wu, D. K. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00287-8 · Cited by 276
Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution
Durruthy-Durruthy, R., Gottlieb, A., Hartman, B. H., Waldhaus, J., Laske, R. D., Altman, R., & Heller, S. (2014) · Cell · doi:10.1016/j.cell.2014.03.036 · Cited by 148
Metadata
- Authors
- Kim, W.-Y., Fritzsch, B., Serls, A., Bakel, L. A., Huang, E. J., Reichardt, L. F., Barth, D. S., & Lee, J. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-02-01
- Volume
- 128
- Issue
- 3
- Pages
- 417-426
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2168944480
- Cited by
- 318
- References
- 2
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- green
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