The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Developmentally distinct MYB genes encode functionally equivalent proteins in Arabidopsis
Abstract
The duplication and divergence of developmental control genes is thought to have driven morphological diversification during the evolution of multicellular organisms. To examine the molecular basis of this process, we analyzed the functional relationship between two paralogous MYB transcription factor genes, WEREWOLF (WER) and GLABROUS1 (GL1), in Arabidopsis. The WER and GL1 genes specify distinct cell types and exhibit non-overlapping expression patterns during Arabidopsis development. Nevertheless, reciprocal complementation experiments with a series of gene fusions showed that WER and GL1 encode functionally equivalent proteins, and their unique roles in plant development are entirely due to differences in their cis-regulatory sequences. Similar experiments with a distantly related MYB gene (MYB2) showed that its product cannot functionally substitute for WER or GL1. Furthermore, an analysis of the WER and GL1 proteins shows that conserved sequences correspond to specific functional domains. These results provide new insights into the evolution of the MYB gene family in Arabidopsis, and, more generally, they demonstrate that novel developmental gene function may arise solely by the modification of cis-regulatory sequences.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The limits of selection during maize domestication
Wang, R.-L., Stec, A., Hey, J., Lukens, L., & Doebley, J. (1999) · Nature · doi:10.1038/18435 · Cited by 740
Transcriptional regulators and the evolution of plant form
Doebley, J., & Lukens, L. (1998) · The Plant Cell · doi:10.1105/tpc.10.7.1075 · Cited by 421
Cited by
MYB transcription factors in Arabidopsis
Dubos, C., Stracke, R., Grotewold, E., Weisshaar, B., Martin, C., & Lepiniec, L. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.06.005 · Cited by 4,865
Evolutionary and comparative analysis of MYB and bHLH plant transcription factors
Feller, A., Machemer, K., Braun, E. L., & Grotewold, E. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04459.x · Cited by 1,348
Yanhui, C., Xiaoyuan, Y., Kun, H., Meihua, L., Jigang, L., Zhaofeng, G., Zhiqiang, L., Yunfei, Z., Xiaoxiao, W., Xiaoming, Q., et al. (2006) · Plant Molecular Biology · doi:10.1007/s11103-005-2910-y · Cited by 992
Zimmermann, I. M., Heim, M. A., Weisshaar, B., & Uhrig, J. F. (2004) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02183.x · Cited by 845
Mehrtens, F., Kranz, H., Bednarek, P., & Weisshaar, B. (2005) · Plant Physiology · doi:10.1104/pp.104.058032 · Cited by 831
A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis
Zhang, F., Gonzalez, A., Zhao, M., Payne, C. T., & Lloyd, A. (2003) · Development · doi:10.1242/dev.00681 · Cited by 799
Katiyar, A., Smita, S., Lenka, S. K., Rajwanshi, R., Chinnusamy, V., & Bansal, K. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-544 · Cited by 628
Schwinn, K., Venail, J., Shang, Y., Mackay, S., Alm, V., Butelli, E., Oyama, R., Bailey, P., Davies, K., & Martin, C. (2006) · The Plant Cell · doi:10.1105/tpc.105.039255 · Cited by 573
A Genetic Regulatory Network in the Development of Trichomes and Root Hairs
Ishida, T., Kurata, T., Okada, K., & Wada, T. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092949 · Cited by 521
Kramer, E. M., Jaramillo, M. A., & Di Stilio, V. S. (2004) · Genetics · doi:10.1093/genetics/166.2.1011 · Cited by 444
Shpak, E. D., Berthiaume, C. T., Hill, E. J., & Torii, K. U. (2004) · Development · doi:10.1242/dev.01028 · Cited by 432
Broun, P. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.03.006 · Cited by 427
Quattrocchio, F., Verweij, W., Kroon, A., Spelt, C., Mol, J., & Koes, R. (2006) · The Plant Cell · doi:10.1105/tpc.105.034041 · Cited by 401
Control of Plant Trichome Development by a Cotton Fiber MYB Gene[W]
Wang, S., Wang, J.-W., Yu, N., Li, C.-H., Luo, B., Gou, J.-Y., Wang, L.-J., & Chen, X.-Y. (2004) · The Plant Cell · doi:10.1105/tpc.104.024844 · Cited by 371
Friedrichsen, D. M., Nemhauser, J., Muramitsu, T., Maloof, J. N., Alonso, J., Ecker, J. R., Furuya, M., & Chory, J. (2002) · Genetics · doi:10.1093/genetics/162.3.1445 · Cited by 321
Schmitz, G., Tillmann, E., Carriero, F., Fiore, C., Cellini, F., & Theres, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022516199 · Cited by 274
Biochemical and molecular characterization of plant MYB transcription factor family
Du, H., Zhang, L., Liu, L., Tang, X.-F., Yang, W.-J., Wu, Y.-M., Huang, Y.-B., & Tang, Y.-X. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909010015 · Cited by 264
Metadata
- Authors
- Lee, M. M., & Schiefelbein, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-05-01
- Volume
- 128
- Issue
- 9
- Pages
- 1539-1546
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2113575935
- Cited by
- 193
- References
- 2
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
