The DOI matches its Crossref record.
Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development
Abstract
Neural crest is induced at the junction of epidermal ectoderm and neural plate by the mutual interaction of these tissues. In previous studies, BMP4 has been shown to pattern the ectodermal tissues, and BMP4 can induce neural crest cells from the neural plate. In this study, we show that epidermally expressed Delta1, which encodes a Notch ligand, is required for the activation and/or maintenance of Bmp4 expression in this tissue, and is thus indirectly required for neural crest induction by BMP4 at the epidermis-neural plate boundary. Notch activation in the epidermis additionally inhibits neural crest formation in this tissue, so that neural crest generation by BMP4 is restricted to the junction.
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Citations
Cited by
Establishing neural crest identity: a gene regulatory recipe
Simões-Costa, M., & Bronner, M. E. (2015) · Development · doi:10.1242/dev.105445 · Cited by 649
lockjaw encodes a zebrafish tfap2a required for early neural crest development
Knight, R. D., Nair, S., Nelson, S. S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.-J., & Schilling, T. F. (2003) · Development · doi:10.1242/dev.00575 · Cited by 186
Insights From a Sea Lamprey Into the Evolution of Neural Crest Gene Regulatory Network
Sauka-Spengler, T., & Bronner-Fraser, M. (2008) · The Biological Bulletin · doi:10.2307/25470671 · Cited by 55
Signaling pathways regulating ectodermal cell fate choices
Patthey, C., & Gunhaga, L. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.002 · Cited by 54
Metadata
- Authors
- Endo, Y., Osumi, N., & Wakamatsu, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-02-15
- Volume
- 129
- Issue
- 4
- Pages
- 863-873
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2166463603
- Cited by
- 186
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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