Establishing neural crest identity: a gene regulatory recipe

Simões-Costa, Marcos; Bronner, Marianne E.

doi:10.1242/dev.105445

Cited by 649Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsCongenital gastrointestinal and neural anomalies

Establishing neural crest identity: a gene regulatory recipe

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Simões-Costa, Marcos, Bronner, Marianne E.·2015·Development

DOI 10.1242/dev.105445PMC PMC4302844

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Abstract

The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of cell types. Neural crest development is thought to be controlled by a suite of transcriptional and epigenetic inputs arranged hierarchically in a gene regulatory network. Here, we examine neural crest development from a gene regulatory perspective and discuss how the underlying genetic circuitry results in the features that define this unique cell population.

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Our data formally establish tfec as a member of the GRN governing maintenance of NCC progenitors.
“Our data formally establish tfec as a member of the GRN governing maintenance of NCC progenitors [41].”
From The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor (2021) · cites this paper as [41]
The study identifies upstream regulators of tfec in multipotent premigratory NC.
“Importantly, we identify its upstream regulators in the multipotent premigratory NC, thus for the first time placing the transcription factor in context in the NCC specification GRN [41].”
From The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor (2021) · cites this paper as [41]
The neural crest specifier genes and Regulatory interactions in the migratory neural crest sections discuss regulators and premigratory neural crest, but the passages found do not identify upstream regulators of tfec. Searches for “tfec” and “tfec upstream regulators premigratory neural crest” found no passage addressing that specific claim. In the citing sentence, “we identify” also describes the citing authors’ own finding, rather than explicitly attributing it to this review. (LLM, conf=0.76)
Experimental — accuracy not yet measured
NR2F1 plays a role in regulating neural crest specifier genes and has undergone selection in AMH.
“NR2F1, which plays a role in regulating neural crest specifier genes and has undergone selection in AMH [64, 65]”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [65]

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Multiple roles of Sox2, an HMG‐box transcription factor in avian neural crest development
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Dnmt3 and G9a Cooperate for Tissue-specific Development in Zebrafish
Rai, K., Jafri, I. F., Chidester, S., James, S. R., Karpf, A. R., Cairns, B. R., & Jones, D. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073676 · Cited by 125 · see citing works
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LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest
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Epigenetic regulation of development by histone lysine methylation
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Lineage Diversification of the Neural Crest: In Vitro Investigations
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Melanocyte-specific Microphthalmia-associated Transcription Factor Isoform Activates Its Own Gene Promoter through Physical Interaction with Lymphoid-enhancing Factor 1
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The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes
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Dissecting early regulatory relationships in the lamprey neural crest gene network
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Transcription Factor AP-2 Is an Essential and Direct Regulator of Epidermal Development in Xenopus
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Functional analysis of Sox8 during neural crest development inXenopus
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BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways
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Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population
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Transcriptional control of differentiation and neurogenesis in autonomic ganglia
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Slug is a downstream mediator of transforming growth factor‐β1‐induced matrix metalloproteinase‐9 expression and invasion of oral cancer cells
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Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm
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Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling
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The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development
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Collective cell migration of the cephalic neural crest: The art of integrating information
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HDAC1 and HDAC2 Control the Specification of Neural Crest Cells into Peripheral Glia
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A far-upstream (−70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration
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Activation of Six1 target genes is required for sensory placode formation
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Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo
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Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives
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Xenopus cadherin-11 is expressed in different populations of migrating neural crest cells
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colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis
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Regulation of the tyrosine hydroxylase and dopamine β‐hydroxylase genes by the transcription factor AP‐2
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Transcription factor Sox10 orchestrates activity of a neural crest-specific enhancer in the vicinity of its gene
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A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
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DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transitionPreprint
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Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR
Sato, S., Ikeda, K., Shioi, G., Ochi, H., Ogino, H., Yajima, H., & Kawakami, K. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.04.029 · Cited by 74 · see citing works
An Iterative Genetic and Dynamical Modelling Approach Identifies Novel Features of the Gene Regulatory Network Underlying Melanocyte Development
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Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition
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A gene network that coordinates preplacodal competence and neural crest specification in zebrafish
Bhat, N., Kwon, H., & Riley, B. B. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.10.012 · Cited by 67 · see citing works
SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer
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The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10
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Identification of Pax3 and Zic1 targets in the developing neural crest
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The small GTPase RhoV is an essential regulator of neural crest induction in Xenopus
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FGF signaling transforms non-neural ectoderm into neural crest
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Identification and dissection of a key enhancer mediating cranial neural crest specific expression of transcription factor, Ets-1
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Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification
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LMO4 is an Essential Cofactor in the Snail2-Mediated Epithelial-to-Mesenchymal Transition of Neuroblastoma and Neural Crest Cells
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The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification
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An essential role ofXenopus Foxi1afor ventral specification of the cephalic ectoderm during gastrulation
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Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus
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Odd-skipped related-1 controls neural crest chondrogenesis during tongue development
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Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial to mesenchymal transition that maintains Cadherin6B protein
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DNA Methyltransferase 3b Is Dispensable for Mouse Neural Crest Development
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PleiotRHOpic
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A new long form of SOX5, SOX6, and SOX9 are co-expressed in chondrocytes and cooperatively activate the type ii collagen gene
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Research works printed but not linked: 2

Horstadius, S. (1950). The Neural Crest. Oxford University Press.
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EMT: 2016
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Authors: Simões-Costa, M., & Bronner, M. E.
Affiliations: California Institute of Technology (US)
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA
ORCID: Simões-Costa, Marcos
Venue: Development
Publisher: The Company of Biologists
Published: 2015-01-15
Volume: 142
Issue: 2
Pages: 242-257
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.105445
PMC: PMC4302844
OpenAlex: W2134374915
Cited by: 649
References: 162
Citations by year: 2026: 48 · 2025: 56 · 2024: 56 · 2023: 54 · 2022: 45 · 2021: 76 · 2020: 63 · 2019: 69 · 2018: 66 · 2017: 43 · 2016: 52 · 2015: 21
FWCI: 5.88
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institutes of Health
National Institute of Dental and Craniofacial Research (K99DE024232)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: neural crest, neural crest development, cell identity, gene regulatory networks, transcriptional regulation, epigenetic regulation, multipotency, cell motility, sensory ganglia, autonomic ganglia, pigment cells, stem/progenitor cells
MeSH terms: Animals, Cell Differentiation, Models, Biological, Neural Crest, Vertebrates, Gene Expression Regulation, Developmental, Epigenesis, Genetic, Gene Regulatory Networks

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Establishing neural crest identity: a gene regulatory recipe

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