The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
KRAB zinc finger proteins
Open accessAbstract
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, together with their co-factor KAP1 (also known as TRIM28), in repression of sequences derived from transposable elements (TEs). Until recently, KRAB-ZFP/KAP1-mediated repression of TEs was thought to lead to irreversible silencing, and the evolutionary selection of KRAB-ZFPs was considered to be just the host component of an arms race against TEs. However, recent advances indicate that KRAB-ZFPs and their TE targets also partner up to establish species-specific regulatory networks. Here, we provide an overview of the KRAB-ZFP gene family, highlighting how its evolutionary history is linked to that of TEs, and how KRAB-ZFPs influence multiple aspects of development and physiology.
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KAP1 controls endogenous retroviruses in embryonic stem cells
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Self-citationRoles for retrotransposon insertions in human disease
Hancks, D. C., & Kazazian, H. H. (2016) · Mobile DNA · doi:10.1186/s13100-016-0065-9 · Cited by 670
KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks
Imbeault, M., Helleboid, P.-Y., & Trono, D. (2017) · Nature · doi:10.1038/nature21683 · Cited by 623
Self-citationAn evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons
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Endogenous retroviruses function as species-specific enhancer elements in the placenta
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Embryonic stem cells use ZFP809 to silence retroviral DNAs
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Cited by
The Human Transcription Factors
Lambert, S. A., Jolma, A., Campitelli, L. F., Das, P. K., Yin, Y., Albu, M., Chen, X., Taipale, J., Hughes, T. R., & Weirauch, M. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.029 · Cited by 3,399
Ten things you should know about transposable elements
Bourque, G., Burns, K. H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., Izsvák, Z., Levin, H. L., Macfarlan, T. S., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1577-z · Cited by 1,430
Self-citationDual proteome-scale networks reveal cell-specific remodeling of the human interactome
Huttlin, E. L., Bruckner, R. J., Navarrete-Perea, J., Cannon, J. R., Baltier, K., Gebreab, F., Gygi, M. P., Thornock, A., Zarraga, G., Tam, S., et al. (2020) · doi:10.1101/2020.01.19.905109 · Cited by 960
Transposable Elements, Inflammation, and Neurological Disease
Saleh, A., Macia, A., & Muotri, A. R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00894 · Cited by 149
Zhang, Y., Amaral, M. L., Zhu, C., Grieco, S. F., Hou, X., Lin, L., Buchanan, J., Tong, L., Preissl, S., Xu, X., et al. (2022) · Cell Research · doi:10.1038/s41422-022-00719-6 · Cited by 89
Analog epigenetic memory revealed by targeted chromatin editing
Palacios, S., Bruno, S., Weiss, R., Salibi, E., Kane, A., Ilia, K., & Del Vecchio, D. (2024) · doi:10.1101/2024.02.13.580200 · Cited by 13
Metadata
- Authors
- Ecco, G., Imbeault, M., & Trono, D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2017-08-01
- Volume
- 144
- Issue
- 15
- Pages
- 2719-2729
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2739782708
- Cited by
- 389
- References
- 19
- FWCI
- 23.68
- Type
- journal article
- Language
- en
- Open access
- green
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