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Cited by 149Chromosomal and Genetic VariationsNeuroinflammation and Neurodegeneration MechanismsGenomic variations and chromosomal abnormalities

Transposable Elements, Inflammation, and Neurological Disease

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Saleh, Aurian, Macia, Angela, Muotri, Alysson R.·2019·Frontiers in Neurology
DOI 10.3389/fneur.2019.00894PMC PMC6710400
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Abstract

Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-understood. Indeed, retrotransposons have evaded evolutionary attempts at repression and may contribute to somatic mosaicism. Retrotransposons are emerging as potent regulatory elements within the human genome. In the diseased state, there is mounting evidence that endogenous retroelements play a role in etiopathogenesis of inflammatory diseases, with a disposition for both autoimmune and neurological disorders. We postulate that active mobile genetic elements contribute more to human disease pathogenesis than previously thought.

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  • Several groups have independently detected elevated TE transcripts in human AD, adding to an intriguing phenomenon of TE dysregulation in neurodegenerative diseases.

    “Several groups have independently detected elevated TE transcripts in human AD [122–124], adding to an intriguing phenomenon of TE dysregulation in neurodegenerative diseases [125–128].”

    From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [127]

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Cited by

Sorted by citations

Authors
Saleh, A., Macia, A., & Muotri, A. R.
Affiliations
University of California San Diego (US)
Corresponding author
Muotri, Alysson R.
ORCID
Muotri, Alysson R.
Venue
Frontiers in Neurology
Publisher
Frontiers Media SA
Published
2019-08-20
Volume
10
Pages
894-894
ISSN
1664-2295 (ISSN-L)
DOI
10.3389/fneur.2019.00894
PMC
PMC6710400
OpenAlex
W2966850360
Cited by
149
References
15
Citations by year
2026: 15 · 2025: 18 · 2024: 17 · 2023: 18 · 2022: 24 · 2021: 32 · 2020: 25
FWCI
1.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neurology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • California Institute for Regenerative Medicine (DISC1-08825)
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health
  • National Institute of Mental Health (R01MH094753)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
transposable elements, retrotransposons, endogenous retroelements, inflammation, autoimmune disease, neurological disorders, somatic mosaicism, mobile genetic elements, pathogenesis, epigenetic regulation

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