The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
Development of the thyroid gland
Abstract
Thyroid hormones are crucial for organismal development and homeostasis. In humans, untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism, which comprises irreversible brain dysfunction and dwarfism. Elucidating how the thyroid gland – the only source of thyroid hormones in the body – develops is thus key for understanding and treating thyroid dysgenesis, and for generating thyroid cells in vitro that might be used for cell-based therapies. Here, we review the principal mechanisms involved in thyroid organogenesis and functional differentiation, highlighting how the thyroid forerunner evolved from the endostyle in protochordates to the endocrine gland found in vertebrates. New findings on the specification and fate decisions of thyroid progenitors, and the morphogenesis of precursor cells into hormone-producing follicular units, are also discussed.
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Cites
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“It is known that Foxa2, which is absolutely required for endoderm formation (Ang et al., 1993; Monaghan et al., 1993), is downregulated specifically in the mouse thyroid bud as compared with the adjacent endoderm and lung bud (Fagman et al., 2011).”
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Cited by
DIAGNOSIS OF ENDOCRINE DISEASE: Congenital hypothyroidism: update and perspectives
Peters, C., van Trotsenburg, A. S. P., & Schoenmakers, N. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0383 · Cited by 162
TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology
Stoupa, A., Adam, F., Kariyawasam, D., Strassel, C., Gawade, S., Szinnai, G., Kauskot, A., Lasne, D., Janke, C., Natarajan, K., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809569 · Cited by 71
The colorful diversity of thyroid hormone metabolites
Köhrle, J. (2019) · European Thyroid Journal · doi:10.1159/000497141 · Cited by 67
Thyroid function across the lifespan: do age-related changes matter?
Walsh, J. P. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1463 · Cited by 59
López-Márquez, A., Carrasco-López, C., Fernández-Méndez, C., & Santisteban, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.654569 · Cited by 49
Metadata
- Authors
- Nilsson, M., & Fagman, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2017-06-15
- Volume
- 144
- Issue
- 12
- Pages
- 2123-2140
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2697546557
- Cited by
- 286
- References
- 137
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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