The hope and the hype of organoid research

Huch, Meritxell, Knoblich, Juergen A., Lutolf, Matthias P., Martinez-Arias, Alfonso·2017·Development

Cited by (409)

Items 201–300 of 409

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  2. The Human Cell Atlas: making ‘cell space’ for disease
    Chris P. Ponting · 2019 · Disease Models & Mechanisms
  3. Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence
    Francesco Cambuli, Veronica Foletto, Alessandro Alaimo, Dario De Felice, Francesco Gandolfi, Maria Dilia Palumbieri, Michela Zaffagni, Sacha Genovesi, Marco Lorenzoni, Martina Celotti et al. · 2022 · EMBO Reports
  4. Modelling adult stem cells and their niche in health and disease with epithelial organoids
    Lili Szabó, Anna C. Seubert, Kai Kretzschmar · 2022 · Seminars in Cell and Developmental Biology
  5. A modular platform to generate functional sympathetic neuron-innervated heart assembloids
    Nadja Zeltner, Hsueh‐Fu Wu, Kenyi Saito‐Diaz, Xin Sun, Ming Song, Tripti Saini, Courtney Grant, Christina James, Kimata Safi Thomas, Yohannes Abate et al. · 2024 · Research Square
  6. Focus on the road to modelling cardiomyopathy in muscular dystrophy
    Francesco Canonico, Maila Chirivì, Fabio Maiullari, Marika Milan, Roberto Rizzi, Alessandra Arcudi, Mattía Galli, Marika Pane, Aoife Gowran, Giulio Pompilio et al. · 2021 · Cardiovascular Research
  7. Development of gemcitabine-modified miRNA mimics as cancer therapeutics for pancreatic ductal adenocarcinoma
    John G. Yuen, Ga‐Ram Hwang, Andrew T. Fesler, Erick Intriago, A.S. Pal, Anushka Ojha, Jingfang Ju · 2024 · Molecular Therapy Oncology
  8. Advanced bioengineering technologies for preclinical research
    Elena Martínez, Jean‐Philippe St‐Pierre, Fabio Variola · 2019 · Advances in Physics X
  9. Intestinal Organoids: A Model to Study the Role of Microbiota in the Colonic Tumor Microenvironment
    Harika Nalluri, Subbaya Subramanian, Christopher M. Staley · 2020 · Future Microbiology
  10. Three-Dimensional Cell Culture Systems in Pediatric and Adult Brain Tumor Precision Medicine
    Nicole C. Riedel, Flavia W. de Faria, Amelie Alfert, Jan M. Bruder, Kornelius Kerl · 2022 · Cancers
  11. Self‐organization of human iPS cells into trophectoderm mimicking cysts induced by adhesion restriction using microstructured mesh scaffolds
    Kennedy Omondi Okeyo, Maiko Tanabe, Osamu Kurosawa, Hidehiro Oana, Masao Washizu · 2018 · Development Growth & Differentiation
  12. The end of ‘mini-brains’! Responsible communication of brain organoid research
    Katherine C. Bassil · 2024 · Molecular Psychology Brain Behavior and Society
  13. Characterization of normal and cancer stem-like cell populations in murine lingual epithelial organoids using single-cell RNA sequencing
    Erik Johansson, Hiroo Ueno · 2021 · Scientific Reports
  14. Approximated gene expression trajectories for gene regulatory network inference on cell tracks
    Kay Spiess, Shannon E. Taylor, Timothy Fulton, Kane Toh, Dillan Saunders, Seongwon Hwang, Yuxuan Wang, Brooks Paige, Benjamin Steventon, Berta Verd · 2024 · iScience
  15. Urine Sample-Derived Cerebral Organoids Suitable for Studying Neurodevelopment and Pharmacological Responses
    Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Liang‐Jun Yan, Yu-Chieh Wang · 2020 · Frontiers in Cell and Developmental Biology
  16. An Ex Vivo Acid Injury and Repair (AIR) Model Using Precision‐Cut Lung Slices to Understand Lung Injury and Repair
    Sally Yunsun Kim, Róisín Mongey, Mark Griffiths, Matthew David Hind, Charlotte H. Dean · 2020 · Current Protocols in Mouse Biology
  17. An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation
    Antonius Chrisnandy, Matthias P. Lütolf · 2025 · Developmental Cell
  18. Cardiac Organoids: A 3D Technology for Disease Modeling and Drug Screening
    Yuxin Zhu, Sheng Yang, Tianyi Zhang, Yiling Ge, Xin Wan, Geyu Liang · 2023 · Current Medicinal Chemistry
  19. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Nontraditional In Vivo Approaches
    Jinping Gan, Brad N. Bolon, Terry Van Vleet, Charles E. Wood · 2021 · Elsevier eBooks
  20. Application of Organoids in Carcinogenesis Modeling and Tumor Vaccination
    Zeyu Wang, Shasha Zhao, Xiaolin Lin, Guanglong Chen, Jiawei Kang, Zhongping Ma, Yiming Wang, Zhi Li, Xiuying Xiao, Aina He et al. · 2022 · Frontiers in Oncology
  21. Using epigenomics to understand cellular responses to environmental influences in diseases
    Julia J. Wattacheril, Srilakshmi M. Raj, David A. Knowles, John M. Greally · 2023 · PLoS Genetics
  22. Systematic comparison of transcriptomes of Caco-2 cells cultured under different cellular and physiological conditions
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  23. A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry
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  24. Application and prospect of organoid technology in breast cancer
    Shanlin Huang, Zifan Mei, Andi Wan, Min Zhao, Xiaowei Qi · 2024 · Frontiers in Immunology
  25. Engineering organoid microfluidic system for biomedical and health engineering: A review
    Yifan Xing, Junyu Liu, Xiaojie Guo, Haipeng Liu, Wen Zeng, Yi Wang, Chong Zhang, Yuan Lu, He Dong, Shaohua Ma et al. · 2020 · Chinese Journal of Chemical Engineering
  26. Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models
    Md Fayad Hasan, Eugenia V. Trushina · 2022 · Brain Sciences
  27. Organoids in the Clinic: A Systematic Review of Outcomes
    Bjørn Hofmann, Severin Zinöcker, Søren Holm, Jonathan Lewis, Panagiotis Kavouras · 2022 · Cells Tissues Organs
  28. The Manufacture and Characterization of Biomimetic, Biomaterial‐Based Scaffolds for Studying Physicochemical Interactions of Neural Cells in 3D Environments
    Cian O’Connor, Ian Woods, Alan Hibbitts, Adrian G. Dervan, Fergal J. O’Brien · 2023 · Current Protocols
  29. Liver organoids and their application in liver cancer research
    Xinyu Song, Kaifei Hou, Hongyan Zhou, Jingyi Yang, Ting Cao, Jiayu Zhang · 2023 · Regenerative Therapy
  30. Species Choice and Model Use: Reviving Research on Human Development
    Nick Hopwood · 2024 · Journal of the History of Biology
  31. Comparative Efficacy of 3Dimensional (3D) Cell Culture Organoids Vs 2Dimensional (2D) Cell Cultures Vs Experimental Animal Models In Disease modeling, Drug development, And Drug Toxicity Testing
    Santenna Chenchula, Sunil Kumar, Shoban Babu Varthya · 2019 · International Journal of Current Research and Review
  32. Topographic Cues Impact on Embryonic Stem Cell Zscan4-Metastate
    Carlo F. Natale, Tiziana Angrisano, Luigi Pistelli, Geppino Falco, Viola Calabrò, Paolo A. Netti, Maurizio Ventre · 2020 · Frontiers in Bioengineering and Biotechnology
  33. Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms
    Agustín Cota-Coronado, Jennifer C. Durnall, Néstor Fabián Díaz, Lachlan H. Thompson, N.E. Díaz-Martínez · 2020 · Molecules
  34. Better governance starts with better words: why responsible human tissue research demands a change of language
    Michael A. Lensink, Karin Rolanda Jongsma, Sarah N. Boers, Annelien L. Bredenoord · 2022 · BMC Medical Ethics
  35. Opinion: Are Organoids the End of Model Evolution for Studying Host Intestinal Epithelium/Microbe Interactions?
    Michelle M. George, Mushfiqur Rahman, Jessica Connors, Andrew W. Stadnyk · 2019 · Microorganisms
  36. Production of Phenotypically Uniform Human Cerebral Organoids from Pluripotent Stem Cells
    Adam Sivitilli, Parisa Ghiasi, Liliana Attisano · 2021 · BIO-PROTOCOL
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    Vojtěch Gabriel, Christopher Zdyrski, Dipak Kumar Sahoo, Kimberly Dao, Agnes Bourgois‐Mochel, Todd A. Atherly, Marilyn N. Martinez, Donna A. Volpe, Jamie J. Kopper, Karin Allenspach et al. · 2022 · Journal of Visualized Experiments
  38. Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics
    Paul C. Hourd, David Williams · 2018 · Cytotherapy
  39. Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs
    Mher Garibyan, Tyler Hoffman, Thijs Makaske, Stephanie Do, Alexander R. March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Potential Application of Intestinal Organoids in Intestinal Diseases
    Wenxiu Liu, Qian Wang, Yanrui Bai, Han Xiao, Zhunduo Li, Qi Wang, Jing Yang, Jing Yang, Hui Sun · 2023 · Stem Cell Reviews and Reports
  41. Organs by design: can bioprinting meet self-organization?
    Iván Martín, Jos Malda, Nicolas C. Rivron · 2019 · Current Opinion in Organ Transplantation
  42. Establishment of a Cochlear Organoid Platform for Remodeling the Extracellular Matrix
    Nianci Li, Ziyu Zhang, Liyan Zhang, Danqi Wu, Zhe Li, Changling Xu, Qiuhan Sun, Yicheng Lu, Yinyi Zhou, Xiaoyun Qian et al. · 2025 · ACS Nano
  43. Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture
    Rachel H. Giles, Elana M. Meijer, Renée G. C. Maas, Christian G.M. van Dijk, Marianne Christina Verhaar, Caroline Cheng · 2025 · Scientific Reports
  44. Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients
    Elena Daoutsali, Barry A. Pepers, Stavros Stamatakis, Linda M. van der Graaf, Gisela Marie Terwindt, David A. Parfitt, Ronald A.M. Buijsen, Willeke van Roon‐Mom · 2023 · Frontiers in Aging Neuroscience
  45. The end of ‘mini-brains’! Responsible communication of cerebral organoid research
    Katherine C. Bassil · 2023 · Molecular Psychology Brain Behavior and Society
  46. Brains Emerging: On Modularity and Self-organisation of Neural Development In Vivo and In Vitro
    Paul Gottlob Layer · 2019 · Springer eBooks
  47. Fibronectin-conjugated thermoresponsive nanobridges generate three dimensional human pluripotent stem cell cultures for differentiation towards the neural lineages
    Linda Harkness, Xiaoli Chen, Zhongfan Jia, Anthony Mitchell Davies, Michael J. Monteiro, Peter P. Gray, Martín F. Pera · 2019 · Stem Cell Research
  48. IPL Sublamination in Chicken Retinal Spheroids Is Initiated via Müller Cells and Cholinergic Differentiation, and Is Disrupted by NMDA Signaling
    Gesine Bachmann, Florian Frohns, Gopenath Thangaraj, Alexander Bausch, Paul Gottlob Layer · 2019 · Investigative Ophthalmology & Visual Science
  49. A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial differentiation
    Jenny Ostrop, Rosalie T. Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard T. Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  50. In vitro modelling of intramuscular injection site events
    Adam J. S. McCartan, Randall J. Mrsny · 2024 · Expert Opinion on Drug Delivery
  51. Advancements and challenges in culturing patient-derived cancer cells for personalized therapeutics
    Yatian Fu, Bee Luan Khoo, Chwee Teck Lim · 2025 · Frontiers in Lab on a Chip Technologies
  52. Hydrogels: current biomedical applications and future directions
    Hao-Ming Wu, Guang-Hao Piao, Qiu-Qi Chen, Wuzhen Luo, Jiayu Liu, Yi-Xuan Lan, Yu-Ling Wang, Ji-Xin Zhou, Kai-Wen Yang, Jing-Jin Xiao et al. · 2026 · Molecular Biomedicine
  53. Hepatic organoids move from adolescence to maturity
    Yuan Guan, Gary Peltz · 2024 · Liver International
  54. Chick fetal organ spheroids as a model to study development and disease
    Soran Dakhel, Wayne I. L. Davies, Justin Vareecal Joseph, Tushar Tomar, Silvia Remeseiro, Lena Gunhaga · 2021 · BMC Molecular and Cell Biology
  55. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models
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  56. Three-dimensional biological cultures and organoids
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  57. Somite surface tension buffers imprecise segment lengths to ensure left-right symmetry
    Sundar Ram Naganathan, Marko Popović, Andrew C. Oates · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Development of Liver Cancer Organoids: Reproducing Tumor Microenvironment and Advancing Research for Liver Cancer Treatment
    Kangkang Li, Kuiwu Ren, Sen Du, Xiang Gao, Jiangtao Yu · 2024 · Technology in Cancer Research & Treatment
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