Cited by 445

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The maternal-to-zygotic transition revisited

Vastenhouw, Nadine L., Cao, Wen Xi, Lipshitz, Howard D.·2019·Development

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Abstract

The development of animal embryos is initially directed by maternal gene products. Then, during the maternal-to-zygotic transition (MZT), developmental control is handed to the zygotic genome. Extensive research in both vertebrate and invertebrate model organisms has revealed that the MZT can be subdivided into two phases, during which very different modes of gene regulation are implemented: initially, regulation is exclusively post-transcriptional and post-translational, following which gradual activation of the zygotic genome leads to predominance of transcriptional regulation. These changes in the gene expression program of embryos are precisely controlled and highly interconnected. Here, we review current understanding of the mechanisms that underlie handover of developmental control during the MZT.

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Authors: Vastenhouw, N. L., Cao, W. X., & Lipshitz, H. D.
Venue: Development
Publisher: The Company of Biologists
Published: 2019-06-01
Volume: 146
Issue: 11
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.161471
OpenAlex: W2951614277
Cited by: 445
References: 269
FWCI: 12.03
Type: journal article
Language: en
Open access: closed

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The maternal-to-zygotic transition revisited

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