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Cited by 300

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo

Bolton, V. N., Oades, P. J., Johnson, M. H.·1984·Development
DOI 10.1242/dev.79.1.139
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Abstract

The 2-cell stage of mouse embryogenesis is characterized by two phases of α-amanitin-sensitive polypeptide synthetic activity, which appear to mark the first major expression of the embryonic genome, as assessed by examination of in vitro translates of mRNA. Using populations of embryos synchronized to the first cleavage division, we have established that DNA replication takes place over the period 1 to 5 ·5 h after the first cleavage division; the two bursts of putative transcription take place before and immediately after DNA replication, and the translation products are detectable in each case within 3 –4 h. In addition, we have shown that suppression of cytokinesis and the second round of DNA replication does not affect synthesis of the α-amanitin-sensitive polypeptides, and that neither DNA replication nor the loss of maternal mRNA that take place during the 2-cell stage are dependent upon synthesis of the α-amanitin-sensitive polypeptides.

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Metadata

Authors
Bolton, V. N., Oades, P. J., & Johnson, M. H.
Venue
Development
Publisher
The Company of Biologists
Published
1984-02-01
Volume
79
Issue
1
Pages
139-163
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.79.1.139
OpenAlex
W2158130862
Cited by
300
References
34
FWCI
5.02
Type
journal article
Language
en
Open access
closed

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