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A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions
Abstract
The hyaluronate component of the extracellular matrix is a powerfully hydrophilic polymer, capable of osmotically swelling and deswelling by a volume factor of 5 or more. At the time of cartilage condensation in the limb bud the chondrocytes start to produce hyaluronidase, an enzyme which degrades hyaluronate. The consequent deswelling brings the chondrocytes closer together -close enough for intercellular cell tractions to become effective and intercellular junctions to form. By analysing the physicochemical situation we show how these processes, principally the coupling of the osmotic deswelling with cellular traction forces, can produce cartilage condensation patterns resembling those in the early limb bud. In distinction from our earlier model for chondrogenic condensations this mechanism does not depend on cell motions other than convective transport by contraction.
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Cited by
Sekiya, I., Vuoristo, J. T., Larson, B. L., & Prockop, D. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052716199 · Cited by 648
A Morphogenetic Approach to the Origin and Basic Organization of the Tetrapod Limb
Shubin, N. H., & Alberch, P. (1986) · Evolutionary Biology · doi:10.1007/978-1-4615-6983-1_6 · Cited by 592
Spatial pattern formation in chemical and biological systems
Maini, P. K., Painter, K. J., & Nguyen Phong Chau, H. (1997) · Journal of the Chemical Society, Faraday Transactions · doi:10.1039/a702602a · Cited by 334
Self-citationAnalysis of the roles of microvessel endothelial cell random motility and chemotaxis in angiogenesis
Stokes, C. L., & Lauffenburger, D. A. (1991) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(05)80201-2 · Cited by 306
The development of the paired fins in the zebrafish (Danio rerio).
Grandel, H., & Schulte-Merker, S. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00176-2 · Cited by 267
Metadata
- Authors
- Oster, G. F., Murray, J. D., & Maini, P. K.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1985-10-01
- Volume
- 89
- Issue
- 1
- Pages
- 93-112
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2312088971
- Cited by
- 175
- References
- 0
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oster, G. F., Murray, J. D., & Maini, P. K. (1985). A model for chondrogenic condensations in the developing limb: the role of extracellular matrix and cell tractions. Development. https://doi.org/10.1242/dev.89.1.93
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
