The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Drosophila tools and assays for the study of human diseases
Open accessAbstract
Many of the internal organ systems of Drosophila melanogaster are functionally analogous to those in vertebrates, including humans. Although humans and flies differ greatly in terms of their gross morphological and cellular features, many of the molecular mechanisms that govern development and drive cellular and physiological processes are conserved between both organisms. The morphological differences are deceiving and have led researchers to undervalue the study of invertebrate organs in unraveling pathogenic mechanisms of diseases. In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases. We discuss assays that have been developed in flies to study the function of specific genes in the central nervous system, heart, liver and kidney, and provide examples of the use of these assays to address questions related to human diseases. These assays provide us with simple yet powerful tools to study the pathogenic mechanisms associated with human disease-causing genes.
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Cites
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Mutations in NOTCH1 cause aortic valve disease
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
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Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2
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Time-restricted feeding attenuates age-related cardiac decline in Drosophila
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HDAC inhibitors: A new promising drug class in anti-aging research
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Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Yu, Y., Fedele, G., Celardo, I., Loh, S. H. Y., & Martins, L. M. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03926-y · Cited by 46
Viola, C. M., Frittmann, O., Jenkins, H. T., Shafi, T., De Meyts, P., & Brzozowski, A. M. (2023) · Nature Communications · doi:10.1038/s41467-023-41862-x · Cited by 34
A paradigm shift: Bioengineering meets mechanobiology towards overcoming remyelination failure
Carvalho, E. D., Morais, M. R. G., Ferreira, H. P., Silva, M. M. C., Guimarães, S. C., & Pêgo, A. P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121427 · Cited by 16
Tsap, M. I., Yatsenko, A. S., Hegermann, J., Beckmann, B., Tsikas, D., & Shcherbata, H. R. (2024) · eLife · doi:10.7554/elife.98020 · Cited by 8
Metadata
- Authors
- Ugur, B., Chen, K., & Bellen, H. J.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2016-03-01
- Volume
- 9
- Issue
- 3
- Pages
- 235-244
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- OpenAlex
- W2325677894
- Cited by
- 524
- References
- 10
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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