The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Making sense of latent TGFβ activation
Abstract
TGFβ is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, `TGFβ activators,' release TGFβ from its latent state. The unusual temporal discontinuity of TGFβ synthesis and action and the panoply of TGFβ effects contribute to the interest in TGF-β. However, the logical connections between TGFβ synthesis, storage and action are obscure. We consider the latent TGFβ complex as an extracellular sensor in which the TGFβ propeptide functions as the detector, latent-TGFβ-binding protein (LTBP) functions as the localizer, and TGF-β functions as the effector. Such a view provides a logical continuity for various aspects of TGFβ biology and allows us to appreciate TGFβ biology from a new perspective.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Regulation of Cell Survival by Secreted Proneurotrophins
Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670
Osteoclast synthesis and secretion and activation of latent transforming growth factor β
Oursler, M. J. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090402 · Cited by 153
Cited by
TGF-β: the master regulator of fibrosis
Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
The PD‐1 pathway in tolerance and autoimmunity
Francisco, L. M., Sage, P. T., & Sharpe, A. H. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00923.x · Cited by 2,300
Stroke risk factors, genetics, and prevention
Boehme, A. K., Esenwa, C., & Elkind, M. S. V. (2017) · Circulation Research · doi:10.1161/circresaha.116.308398 · Cited by 1,952
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Metadata
- Authors
- Annes, J. P., Munger, J. S., & Rifkin, D. B.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2003-01-15
- Volume
- 116
- Issue
- 2
- Pages
- 217-224
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1575754639
- Cited by
- 1,628
- References
- 3
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Annes, J. P., Munger, J. S., & Rifkin, D. B. (2003). Making sense of latent TGFβ activation. Journal of Cell Science. https://doi.org/10.1242/jcs.00229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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