The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Mechanistic insights from structural studies of β-catenin and its binding partners
Abstract
β-catenin is both a crucial regulator of cell adhesion and the central effector of the canonical Wnt signaling pathway. It functions as a protein organizer by interacting with numerous partners at the membrane, in the cytosol, and in the nucleus. Recent structural and biochemical studies have revealed how β-catenin engages in critical protein-protein interactions by using its armadillo repeat region and its N- and C-terminal domains. The groove in the armadillo repeat region is a particularly interesting feature of β-catenin, since it serves as a common binding site for several β-catenin-binding partners, with steric hindrance limiting which partners can be bound at a specific time. These studies provide important insights into β-catenin-mediated mechanisms of cell adhesion and Wnt signaling and suggest potential approaches for the design of therapeutic agents to treat diseases caused by misregulated β-catenin expression.
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Cites
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β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628 · cited 2×
“…absence of a Wnt signal, cytosolic -catenin is captured and phosphorylated by a cytoplasmic protein complex called the -catenin-destruction complex, which catalyzes the phosphorylation of -catenin and thus labels it for ubiquitindependent degradation by the proteasome (Kimelman and Xu, 2006) (Fig.”
BackgroundSelf-citationXing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes & Development · doi:10.1101/gad.1142603 · Cited by 237 · cited 4×
“4) (Xing et al., 2003).”
BackgroundInfluentialSelf-citationDistinct β-catenins mediate adhesion and signalling functions in C. elegans
Korswagen, H. C., Herman, M. A., & Clevers, H. C. (2000) · Nature · doi:10.1038/35020099 · Cited by 218
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Targeting fibrosis: mechanisms and clinical trials
Zhao, M., Wang, L., Wang, M., Zhou, S., Lu, Y., Cui, H., Racanelli, A. C., Zhang, L., Ye, T., Ding, B., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01070-3 · Cited by 547
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Metadata
- Authors
- Xu, W., & Kimelman, D.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-10-01
- Volume
- 120
- Issue
- 19
- Pages
- 3337-3344
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2095086052
- Cited by
- 246
- References
- 5
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
