The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC
Open accessAbstract
Cdc42 recruits Par-6–aPKC to establish cell polarity from worms to mammals. Although Cdc42 is reported to have no function in Drosophila neuroblasts, a model for cell polarity and asymmetric cell division, we show that Cdc42 colocalizes with Par-6–aPKC at the apical cortex in a Bazooka-dependent manner, and is required for Par-6–aPKC localization. Loss of Cdc42 disrupts neuroblast polarity: cdc42 mutant neuroblasts have cytoplasmic Par-6–aPKC, and this phenotype is mimicked by neuroblast-specific expression of a dominant-negative Cdc42 protein or a Par-6 protein that lacks Cdc42-binding ability. Conversely, expression of constitutively active Cdc42 leads to ectopic Par-6–aPKC localization and corresponding cell polarity defects. Bazooka remains apically enriched in cdc42 mutants. Robust Cdc42 localization requires Par-6, indicating the presence of feedback in this pathway. In addition to regulating Par-6–aPKC localization, Cdc42 increases aPKC activity by relieving Par-6 inhibition. We conclude that Cdc42 regulates aPKC localization and activity downstream of Bazooka, thereby directing neuroblast cell polarity and asymmetric cell division.
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Citations
Cites
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 2×
“Importantly, the reported Par-6–Baz interaction (Joberty et al., 2000; Lin et al., 2000; Wodarz et al., 2000) is insufficient to target Par-6 to the cortex in the absence of the Cdc42–Par-6 interaction.”
BackgroundA mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura, K., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00453.x · Cited by 306
Harris, T. J. C., & Peifer, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505127 · Cited by 295
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
Albertson, R., & Doe, C. Q. (2003) · Nature Cell Biology · doi:10.1038/ncb922 · Cited by 269
Self-citation
Cited by
Coordinated protein sorting, targeting and distribution in polarized cells
Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521
Tepass, U. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154033 · Cited by 334
Actin polymerization controls cilia-mediated signaling
Drummond, M. L., Li, M., Tarapore, E., Nguyen, T. T. L., Barouni, B. J., Cruz, S., Tan, K. C., Oro, A. E., & Atwood, S. X. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201703196 · Cited by 82
Self-citationSynthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
Watson, J. L., Krüger, L. K., Ben-Sasson, A. J., Bittleston, A., Shahbazi, M. N., Planelles-Herrero, V. J., Chambers, J. E., Manton, J. D., Baker, D., & Derivery, E. (2023) · Cell · doi:10.1016/j.cell.2023.08.034 · Cited by 32
Metadata
- Authors
- Atwood, S. X., Chabu, C., Penkert, R. R., Doe, C. Q., & Prehoda, K. E.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2007-09-15
- Volume
- 120
- Issue
- 18
- Pages
- 3200-3206
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2094079751
- Cited by
- 158
- References
- 5
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Atwood, S. X., Chabu, C., Penkert, R. R., Doe, C. Q., & Prehoda, K. E. (2007). Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC. Journal of Cell Science. https://doi.org/10.1242/jcs.014902
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