Coordinated protein sorting, targeting and distribution in polarized cells
Open accessAbstract
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.
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Proper vesicle trafficking is critical for maintaining epithelial polarity.
“In support of this hypothesis, proper vesicle trafficking is critical for maintenance of epithelial polarity (40).”
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Bartter Syndromes and Other Salt-Losing Tubulopathies
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Polarization-Dependent Selective Transport to the Apical Membrane by KIF5B in MDCK Cells
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Regulating cytoskeleton‐based vesicle motility
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FAPP2 is involved in the transport of apical cargo in polarized MDCK cells
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Regulation of Synaptic Plasticity and Synaptic Vesicle Dynamics by the PDZ Protein Scribble
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Rhodopsin Trafficking and its Role in Retinal Dystrophies
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Self-citationPar3 functions in the biogenesis of the primary cilium in polarized epithelial cells
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- Authors
- Mellman, I., & Nelson, W. J.
- Affiliations
- Genentech (US)
- Stanford University (US)
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-11
- Volume
- 9
- Issue
- 11
- Pages
- 833-845
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC3369829
- OpenAlex
- W2057733044
- Cited by
- 521
- References
- 135
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 26 · 2023: 14 · 2022: 20 · 2021: 19 · 2020: 18 · 2019: 16 · 2018: 24 · 2017: 26 · 2016: 34 · 2015: 28 · 2014: 38 · 2013: 53 · 2012: 52
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (GM35527, R37GM035527, R01GM035527)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- cell polarization, protein sorting, protein trafficking, plasma membrane domains, cell adhesion, cell-substrate adhesion, membrane traffic, tissue function
- MeSH terms
- Animals, Cell Membrane, Cytoskeleton, Humans, Pathology, Proteins, Cell Polarity, Protein Transport, Organogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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