Cited by 521Cellular transport and secretionCellular Mechanics and InteractionsRNA Research and Splicing

Coordinated protein sorting, targeting and distribution in polarized cells

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Mellman, Ira, Nelson, W. James·2008·Nature Reviews Molecular Cell Biology

Abstract

The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.

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Authors
Mellman, I., & Nelson, W. J.
Affiliations
  • Genentech (US)
  • Stanford University (US)
Venue
Nature Reviews Molecular Cell Biology
Published
2008-11
Volume
9
Issue
11
Pages
833-845
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2057733044
Cited by
521
References
135
Citations by year
2026: 11 · 2025: 15 · 2024: 26 · 2023: 14 · 2022: 20 · 2021: 19 · 2020: 18 · 2019: 16 · 2018: 24 · 2017: 26 · 2016: 34 · 2015: 28 · 2014: 38 · 2013: 53 · 2012: 52
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of General Medical Sciences (GM35527, R37GM035527, R01GM035527)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
cell polarization, protein sorting, protein trafficking, plasma membrane domains, cell adhesion, cell-substrate adhesion, membrane traffic, tissue function
MeSH terms
Animals, Cell Membrane, Cytoskeleton, Humans, Pathology, Proteins, Cell Polarity, Protein Transport, Organogenesis

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