The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Secrets of a double agent: CDK7 in cell-cycle control and transcription
Abstract
In metazoans, cyclin-dependent kinase 7 (CDK7) has essential roles in both the cell-division cycle and transcription, as a CDK-activating kinase (CAK) and as a component of the general transcription factor TFIIH, respectively. Controversy over its double duty has been resolved, but questions remain. First, how does CDK7 achieve the dual substrate specificity necessary to perform both roles? Second, is there a deeper connection implied by the dichotomy of CDK7 function, for example similar mechanisms controlling cell division and gene expression, and/or actual coordination of the two processes? Enzymological studies have revealed solutions to the unusual substrate recognition problem, and there is evidence that the distinct functions of CDK7 can be regulated independently. Finally, despite divergence in their wiring, the CAK-CDK networks of budding yeast, fission yeast and metazoans all link transcriptional regulation with operation of the cell-cycle machinery. This connection might help to ensure that mRNAs encoding effectors of cell division are expressed at the right time in the cycle.
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Cites
Rochette-Egly, C., Adam, S., Rossignol, M., Egly, J.-M., & Chambon, P. (1997) · Cell · doi:10.1016/s0092-8674(00)80317-7 · Cited by 308 · cited 2×
“…PPARs – which contain sites for phosphorylation by CDK7 (and perhaps other proline-directed kinases) within the conserved activation function 1 (AF1) domain (Rochette-Egly et al., 1997; Chen et al., 2000; Compe et al., 2005), mutation of which to alanine diminishes liganddependent transcription.”
BackgroundReconstitution of the Transcription Factor TFIIH
Tirode, F., Busso, D., Coin, F., & Egly, J.-M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80177-x · Cited by 301
Keriel, A., Stary, A., Sarasin, A., Rochette-Egly, C., & Egly, J.-M. (2002) · Cell · doi:10.1016/s0092-8674(02)00692-x · Cited by 192
Xpd/Ercc2 regulates CAK activity and mitotic progression
Chen, J., Larochelle, S., Li, X., & Suter, B. (2003) · Nature · doi:10.1038/nature01746 · Cited by 127
Cited by
Cell cycle, CDKs and cancer: a changing paradigm
Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957
Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment
Shapiro, G. I. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.7689 · Cited by 1,036
Zheng, P., Xia, Y., Xiao, G., Xiong, C., Hu, X., Zhang, S., Zheng, H., Huang, Y., Zhou, Y., Wang, S., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-11-r116 · Cited by 454
Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors
Peyressatre, M., Prével, C., Pellerano, M., & Morris, M. (2015) · Cancers · doi:10.3390/cancers7010179 · Cited by 344
TFIIH: when transcription met DNA repair
Compe, E., & Egly, J.-M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3350 · Cited by 332
Metadata
- Authors
- Fisher, R. P.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2005-11-15
- Volume
- 118
- Issue
- 22
- Pages
- 5171-5180
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2060334131
- Cited by
- 363
- References
- 4
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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