Cited by 3,957Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, Marcos, Barbacid, Mariano·2009·Nature Reviews Cancer

Abstract

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

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Crossref · 10.1038/nrc2602

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178 of 178 references verified0 citation errors · 0 not checkable

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  • Inactivation of these genes can prevent oncogene-induced tumor development in mouse models, reinforcing that these enzymes might be suitable cancer-specific drug targets.

    “In contrast, the demonstration that inactivation of these genes can prevent oncogene-induced tumor development in mouse models reinforced the view that these enzymes might be suitable cancer-specific drug targets (65).”

    From Targeting CDK4 and CDK6: From Discovery to Therapy (2016) · cites this paper as [65]

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  1. Hanks, S. et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nature Genet. 36, 1159–1161 (2004). · DOI

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Authors
Malumbres, M., & Barbacid, M.
Affiliations
Spanish National Cancer Research Centre (ES)
Venue
Nature Reviews Cancer
Published
2009-03
Volume
9
Issue
3
Pages
153-166
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2046024621
Cited by
3,957
References
178
Citations by year
2026: 191 · 2025: 241 · 2024: 266 · 2023: 277 · 2022: 297 · 2021: 318 · 2020: 272 · 2019: 222 · 2018: 237 · 2017: 260 · 2016: 195 · 2015: 228 · 2014: 218 · 2013: 206 · 2012: 186
FWCI
15.80
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
cyclin-dependent kinases, CDK1, cell cycle, tumor cell proliferation, genomic instability, chromosomal instability, cyclin-dependent kinase inhibitors, selective cancer therapy
MeSH terms
Animals, Cell Cycle, Chromosome Aberrations, DNA Damage, Humans, Mitosis, Neoplasms, Neoplastic Stem Cells, Cyclins, Cyclin-Dependent Kinases, Cyclin E, Chromosomal Instability, Protein Kinase Inhibitors, Cell Proliferation, Cyclin D

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