The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
How can biochemical reactions within cells differ from those in test tubes?
Abstract
Nonspecific interactions between individual macro-molecules and their immediate surroundings (`background interactions') within a medium as heterogeneous and highly volume occupied as the interior of a living cell can greatly influence the equilibria and rates of reactions in which they participate. Background interactions may be either repulsive, leading to preferential size-and-shape-dependent exclusion from highly volume-occupied elements of volume, or attractive, leading to nonspecific associations or adsorption. Nonspecific interactions with different constituents of the cellular interior lead to three classes of phenomena: macromolecular crowding, confinement and adsorption. Theory and experiment have established that predominantly repulsive background interactions tend to enhance the rate and extent of macromolecular associations in solution, whereas predominately attractive background interactions tend to enhance the tendency of macromolecules to associate on adsorbing surfaces. Greater than order-of-magnitude increases in association rate and equilibrium constants attributable to background interactions have been observed in simulated and actual intracellular environments.
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Cites
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Minton, A. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100005200 · Cited by 1,474 · cited 5×
“§Additional relevant observations reported prior to 2003 have been compiled in Minton, 1983; Zimmerman and Minton, 1993; Minton, 2001a; Hall & Minton, 2003.”
BackgroundMethodInfluentialSelf-citationZimmerman, S. B., & Trach, S. O. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90499-v · Cited by 1,337
Excluded volume as a determinant of macromolecular structure and reactivity
Minton, A. P. (1981) · Biopolymers · doi:10.1002/bip.1981.360201006 · Cited by 589
Self-citationScaled Particle Theory of Fluid Mixtures
Lebowitz, J. L., Helfand, E., & Praestgaard, E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1696842 · Cited by 589
Molecular confinement influences protein structure and enhances thermal protein stability
Eggers, D. K., & Valentine, J. S. (2001) · Protein Science · doi:10.1110/ps.36201 · Cited by 393
Minton, A. P., & Wilf, J. (1981) · Biochemistry · doi:10.1021/bi00520a003 · Cited by 320
Self-citationMinton, A. P. (1998) · Methods in Enzymology · doi:10.1016/s0076-6879(98)95038-8 · Cited by 317
Self-citationMinton, A. P. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76576-3 · Cited by 218
Self-citation(1992) · doi:10.1007/978-3-642-76682-4 · Cited by 182
Cited by
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730
Universal physical responses to stretch in the living cell
Trepat, X., Deng, L., An, S. S., Navajas, D., Tschumperlin, D. J., Gerthoffer, W. T., Butler, J. P., & Fredberg, J. J. (2007) · Nature · doi:10.1038/nature05824 · Cited by 699
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
Theillet, F.-X., Binolfi, A., Frembgen-Kesner, T., Hingorani, K., Sarkar, M., Kyne, C., Li, C., Crowley, P. B., Gierasch, L., Pielak, G. J., et al. (2014) · Chemical Reviews · doi:10.1021/cr400695p · Cited by 503
Macromolecular Crowding In Vitro , In Vivo , and In Between
Rivas, G., & Minton, A. P. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.013 · Cited by 470
Self-citationOrganization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 451
Metadata
- Authors
- Minton, A. P.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2006-07-15
- Volume
- 119
- Issue
- 14
- Pages
- 2863-2869
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W4238701569
- Cited by
- 407
- References
- 14
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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