Cited by 370Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

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Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails

Legate, Kyle R., Fässler, Reinhard·2009·Journal of Cell Science

DOI 10.1242/jcs.041624

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Abstract

Cells recognize and respond to their extracellular environment through transmembrane receptors such as integrins, which physically connect the extracellular matrix to the cytoskeleton. Integrins provide the basis for the assembly of intracellular signaling platforms that link to the cytoskeleton and influence nearly every aspect of cell physiology; however, integrins possess no enzymatic or actin-binding activity of their own and thus rely on adaptor molecules, which bind to the short cytoplasmic tails of integrins, to mediate and regulate these functions. Many adaptors compete for relatively few binding sites on integrin tails, so regulatory mechanisms have evolved to reversibly control the spatial and temporal binding of specific adaptors. This Commentary discusses the adaptor proteins that bind directly to the tails of β integrins and, using talin, tensin, filamin, 14-3-3 and integrin-linked kinase (ILK) as examples, describes the ways in which their binding is regulated.

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Authors: Legate, K. R., & Fässler, R.
Affiliations: Max Planck Institute of Biochemistry (DE)
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
ORCID: Legate, Kyle R.
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2009-01-15
Volume: 122
Issue: 2
Pages: 187-198
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.041624
OpenAlex: W2092447350
Cited by: 370
References: 175
Citations by year: 2026: 5 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 19 · 2016: 28 · 2015: 24 · 2014: 28 · 2013: 23 · 2012: 47
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cell Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: beta-integrin, integrin cytoplasmic tail, adaptor proteins, talin, tensin, filamin, 14-3-3 proteins, integrin-linked kinase, integrin signaling, binding regulation, cell adhesion
MeSH terms: Amino Acid Sequence, Animals, Binding Sites, Cytoplasm, Cytoskeletal Proteins, Humans, Microfilament Proteins, Molecular Sequence Data, Sequence Alignment, Integrin beta Chains

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Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails

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