The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Protein localization in disease and therapy
Abstract
The eukaryotic cell is organized into membrane-covered compartments that are characterized by specific sets of proteins and biochemically distinct cellular processes. The appropriate subcellular localization of proteins is crucial because it provides the physiological context for their function. In this Commentary, we give a brief overview of the different mechanisms that are involved in protein trafficking and describe how aberrant localization of proteins contributes to the pathogenesis of many human diseases, such as metabolic, cardiovascular and neurodegenerative diseases, as well as cancer. Accordingly, modifying the disease-related subcellular mislocalization of proteins might be an attractive means of therapeutic intervention. In particular, cellular processes that link protein folding and cell signaling, as well as nuclear import and export, to the subcellular localization of proteins have been proposed as targets for therapeutic intervention. We discuss the concepts involved in the therapeutic restoration of disrupted physiological protein localization and therapeutic mislocalization as a strategy to inactivate disease-causing proteins.
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Cites
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
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IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
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Self-citationMitochondrial protein import: from proteomics to functional mechanisms
Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717
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Cited by
Porath, B., Gainullin, V. G., Cornec-Le Gall, E., Dillinger, E. K., Heyer, C. M., Hopp, K., Edwards, M. E., Madsen, C. D., Mauritz, S. R., Banks, C. J., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.004 · Cited by 475
Localization, Not Important in All Tumor-Suppressing Properties: A Lesson Learnt from Scribble
Elsum, I. A., & Humbert, P. O. (2013) · Cells Tissues Organs · doi:10.1159/000348423 · Cited by 27
Sequence of proteome profiles in preclinical and symptomatic Alzheimer's disease
Li, X., Tsolis, K. C., Koper, M. J., Ronisz, A., Ospitalieri, S., von Arnim, C. A. F., Vandenberghe, R., Tousseyn, T., Scheuerle, A., Economou, A., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12345 · Cited by 27
Wei, Z., Liu, X., Yan, R., Sun, G., Yu, W., Liu, Q., & Guo, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1002327 · Cited by 7
Metadata
- Authors
- Hung, M.-C., & Link, W.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2011-10-15
- Volume
- 124
- Issue
- 20
- Pages
- 3381-3392
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2152482858
- Cited by
- 431
- References
- 6
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
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