TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

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Items 201–300 of 350

1. Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders
   Keiko Tsuji Wakisaka, Ryo Tanaka, Tomoki Hirashima, Yuuka Muraoka, Yumiko Azuma, Hideki Yoshida, Takahiko Tokuda, Satoshi Asada, Kojiro Suda, Kenji Ichiyanagi et al. · 2018 · Brain Research
2. Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration
   Kazuma Murakami, Kenjiro Ono · 2022 · The FASEB Journal
3. Amyotrophic lateral sclerosis
   David S. Younger, Robert H. Brown · 2023 · Handbook of clinical neurology
4. EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions
   Yonglun Luo, Jenny Blechingberg, Ana Miguel Fernandes, Shengting Li, Tue Fryland, Anders Dupont Børglum, Lars Bolund, Anders Lade Nielsen · 2015 · BMC Genomics
5. Pathogenic Genome Signatures That Damage Motor Neurons in Amyotrophic Lateral Sclerosis
   Ali Yousefian-Jazi, YunHee Seol, Jieun Kim, Hannah L. Ryu, Jung-Hee Lee, Hoon Ryu · 2020 · Cells
6. Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats
   Tao Zhang, Xin Jiang, Min Xu, Haifang Wang, Xiao Ming Sang, Meiling Qin, Puhua Bao, Ruiqi L. Wang, Chenchen Zhang, Huiping Lu et al. · 2018 · Neurobiology of Aging
7. Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis
   Lisha Kuang, Marisa Kamelgarn, Alexandra Arenas, József Gál, Deborah Taylor, Weiming Gong, Martin Brown, Daret K. St. Clair, Edward J. Kasarskis, Haining Zhu · 2017 · Neurology Genetics
8. Dbr1 functions in mRNA processing, intron turnover and human diseases
   Arundhati Mohanta, Kausik Chakrabarti · 2020 · Biochimie
9. Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS
   Clara Tejido, Donya Pakravan, Ludo Van Den Bosch · 2021 · Frontiers in Molecular Neuroscience
10. Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?
    Ahmed Abdelhak, Andreas Junker, Johannes Brettschneider, Jan Kassubek, Albert Ludolph, Markus Otto, Hayrettin Tumani · 2015 · International Journal of Molecular Sciences
11. Genetics of essential tremor: From phenotype to genes, insights from both human and mouse studies
    Jean-François Schmouth, Patrick A. Dion, Guy Armand Rouleau · 2014 · Progress in Neurobiology
12. A network of RNA and protein interactions in Fronto Temporal Dementia
    Francesca Fontana, Kavitha Siva, Michela A. Denti · 2015 · Frontiers in Molecular Neuroscience
13. FUS Immunogold Labeling TEM Analysis of the Neuronal Cytoplasmic Inclusions of Neuronal Intermediate Filament Inclusion Disease: A Frontotemporal Lobar Degeneration with FUS Proteinopathy
    Tristan K.W. Page, Michael A. Gitcho, Sabrina Mosaheb, Deborah R. Carter, Sumi Chakraverty, Robert Henry Perry, Eileen H. Bigio, Marla Gearing, Isidró Ferrer, Alison Goate et al. · 2011 · Journal of Molecular Neuroscience
14. Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway
    Mai Shimamura, Akane Kyotani, Yumiko Azuma, Hideki Yoshida, Thanh Binh Nguyen, Ikuko Mizuta, Tomokatsu Yoshida, Toshiki Mizuno, Masanori Nakagawa, Takahiko Tokuda et al. · 2014 · Experimental Cell Research
15. Characterization of FUS Mutations in Amyotrophic Lateral Sclerosis Using RNA-Seq
    Marka van Blitterswijk, Eric T. Wang, Brad A. Friedman, Pamela J. Keagle, Patrick Lowe, Ashley Lyn LeClerc, Leonard H. van den Berg, David E. Housman, Jan Herman Veldink, John E. Landers · 2013 · PLoS ONE
16. A protein–protein interaction of stress‐responsive myosin VI endowed to inhibit neural progenitor self‐replication with RNA binding protein, TLS, in murine hippocampus
    Takeshi Takarada, Keisuke Tamaki, Toru Takumi, Masato Ogura, Yuma Ito, Noritaka Nakamichi, Yukio Yoneda · 2009 · Journal of Neurochemistry
17. Overexpression of nuclear FUS induces neuronal cell death
    Hiroaki Suzuki, Masaaki Matsuoka · 2014 · Neuroscience
18. FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress
    María Isabel Martínez-Macías, Duncan A.Q. Moore, Ryan L. Green, Fernando Gómez-Herreros, Marcel Naumann, Andreas Hermann, Philip Van Damme, Majid Hafezparast, Keith W. Caldecott · 2019 · Life Science Alliance
19. Dynamic Subcellular Localization of the Ewing Sarcoma Proto-Oncoprotein and Its Association with and Stabilization of Microtubules
    Ruzanna P. Leemann-Zakaryan, Steffen Pahlich, Maria José Sedda, Lilian Quero, Doris Grossenbacher, Heinz Gehring · 2008 · Journal of Molecular Biology
20. KIN17 encodes an RNA-binding protein and is expressed during mouse spermatogenesis
    Ghislaine Pinon‐Lataillade, Christel Masson, Jacqueline Bernardino-Sgherri, Véronique Henriot, Philippe Mauffrey, Yveline Frobert, Silvia Araneda, Jaime F. Angulo · 2004 · Journal of Cell Science
21. Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation
    Francesca Svetoni, Elisa De Paola, Piergiorgio La Rosa, Neri Mercatelli, Daniela Caporossi, Claudio Sette, Maria Paola Paronetto · 2017 · Human Molecular Genetics
22. TAF15 contributes to the radiation-inducible stress response in cancer
    Abhay Kumar Singh, Vaishali Kapoor, Dinesh Kumar Thotala, Dennis E. Hallahan · 2020 · Oncotarget
23. The FUS protein: Physiological functions and a role in amyotrophic lateral sclerosis
    A. D. Efimova, Р. К. Овчинников, Andrei Yu. Roman, Andrey V. Maltsev, Vladimir V. Grigoriev, Elena A Kovrazhkina, Veronica I. Skvortsova · 2017 · Molecular Biology
24. Elevated FUS/TLS expression is negatively associated with E‑cadherin expression and prognosis of patients with non‑small cell lung cancer
    Dian Xiong, Yongbing Wu, Chun Jin, Jijun Li, Jie Gu, Yunfei Liao, Xiang Long, Shu‐Qiang Zhu, Haibo Wu, Jianjun Xu et al. · 2018 · Oncology Letters
25. The binding specificity of Translocated in LipoSarcoma/FUsed in Sarcoma with lncRNA transcribed from the promoter region of cyclin D1
    Ryoma Yoneda, Shiho Suzuki, Tsukasa Mashima, Keiko Kondo, Takashi Nagata, Masato Katahira, Riki Kurokawa · 2016 · Cell & Bioscience
26. Genetic architecture of motor neuron diseases
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27. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif
    Hannah K. Robinson, Alexey V. Deykin, Evgeny V. Bronovitsky, Ruslan K. Ovchinnikov, A. A. Ustyugov, Tatyana A. Shelkovnikova, Michail S. Kukharsky, T. G. Ermolkevich, Igor L. Goldman, Елена Рубеновна Садчикова et al. · 2015 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
28. Redox Imbalance in Neurological Disorders in Adults and Children
    Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea et al. · 2023 · Antioxidants
29. The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions
    Izzy Owen, Shannon N. Rhoads, Debra S. Yee, Hala Wyne, Kevin L Gery, Isabelle Hannula, Meenakshi Sundrum, Frank P. Shewmaker · 2020 · Molecular Biology of the Cell
30. The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis
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31. Neurodegenerative Diseases and Ageing
    Lauren Walker, Kirsty E. McAleese, Daniel Erskine, Johannes Attems · 2019 · Sub-cellular biochemistry/Subcellular biochemistry
32. Overexpression of ter94, Drosophila VCP, improves motor neuron degeneration induced by knockdown of TBPH, Drosophila TDP-43.
    Yukie Kushimura, Takahiko Tokuda, Yumiko Azuma, Itaru Yamamoto, Ikuko Mizuta, Toshiki Mizuno, Masanori Nakagawa, Morio Ueyama, Yoshitaka Nagai, Hideki Yoshida et al. · 2018 · Europe PMC (PubMed Central)
33. Temperature-Dependent Localization of TLS?CHOP to Splicing Factor Compartments
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34. FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications
    Kishor Gawade, Patrycja Plewka, Sophia Julia Häfner, Anders Henrik Lund, Virginie Marchand, Yuri Motorin, Michał Wojciech Szcześniak, Katarzyna Dorota Raczyńska · 2023 · Scientific Reports
35. The Potential of Pathological Protein Fragmentation in Blood-Based Biomarker Development for Dementia – With Emphasis on Alzheimer’s Disease
    Dilek Inekci, Ditte Svendsen Jonesco, Sophie Kennard, M.A. Karsdal, Kim Henriksen · 2015 · Frontiers in Neurology
36. Regulation of physiological and pathological condensates by molecular chaperones
    Nadeen Akaree, Valentina Secco, Flonia Levy‐Adam, Amal Younis, Serena Carra, Reut Shalgi · 2025 · FEBS Journal
37. Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis
    Mohamed F. El‐Mansy, Cory T. Reidl, Mizzanoor Rahaman, P. Hande Özdi̇nler, Richard B. Silverman · 2023 · Medicinal Research Reviews
38. Metabolomics: A Tool to Understand the Impact of Genetic Mutations in Amyotrophic Lateral Sclerosis
    Débora Lanznaster, Charlotte Veyrat‐Durebex, Patrick Vourc’h, Christian Robert Andres, Hélène Blasco, Philippe Corcia · 2020 · Genes
39. Protein Aggregates in Pathological Inclusions of Amyotrophic Lateral Sclerosis
    Yoshiaki Furukawa · 2012 · InTech eBooks
40. The Localization of Nuclear DNA Helicase II in Different Nuclear Compartments Is Linked to Transcription
    Beata Fuchsová, Pavel Hozák · 2002 · Experimental Cell Research
41. Progress in Frontotemporal Dementia Research
    Xinling Wang, Yuedi Shen, Wei Chen · 2012 · American Journal of Alzheimer s Disease & Other Dementias®
42. Structural delineation of stem-loop RNA binding by human TAF15 protein
    Kashyap Maruthi, Akshay Kumar Ganguly, Néel Sarovar Bhavesh · 2015 · Scientific Reports
43. VEGF alleviates ALS-CSF induced cytoplasmic accumulations of TDP-43 and FUS/TLS in NSC-34 cells
    Shubham Shantanu, Kandasamy Vijayalakshmi, Shruthi Shanmukha, B. K. Chandrasekhar Sagar, Talakad N. Sathyaprabha, Atchayaram Nalini, T.R. Raju, Phalguni Anand Alladi · 2017 · Journal of Chemical Neuroanatomy
44. FUS regulates autophagy by mediating the transcription of genes critical to the autophagosome formation
    Alexandra Arenas, Lisha Kuang, Jia Yu Zhang, Meagan S. Kingren, Haining Zhu · 2020 · Journal of Neurochemistry
45. The function of FUS in neurodevelopment revealed by the brain and spinal cord organoids
    Huan Zou, Junying Wang, Guoming Ma, Meimei Xu, Fang Luo, Lin Zhang, Wenyuan Wang · 2022 · Molecular and Cellular Neuroscience
46. FUS Microphase Separation: Regulation by Nucleic Acid Polymers and DNA Repair Proteins
    Maria V. Sukhanova, Rashid O. Anarbaev, Ekaterina A. Maltseva, David Pastré, Olga I. Lavrik · 2022 · International Journal of Molecular Sciences
47. Aberrant Rna Homeostasis in Amyotrophic Lateral Sclerosis: Potential for New Therapeutic targets?
    Christopher J. Donnelly, Jonathan C. Grima, Rita Sattler · 2014 · Neurodegenerative Disease Management
48. High FUS/TLS expression in acute myeloid leukaemia samples
    Ken Mills, ⁄ Walsh, Gilkes, Sweeney, Mirza, Woodgate, Brown, Burnett · 2000 · British Journal of Haematology
49. PIGPEN AND ENDOTHELIAL CELL DIFFERENTIATION
    Mark C. Alliegro · 2001 · Cell Biology International
50. RNA-Mediated Inhibition Mechanism of Liquid–Liquid Phase Separation and Subsequent Aggregation Revealed by Raman Microscopy
    Taisei Ogura, Uchu Matsuura, Masato Machida, Kaichi Nagai, Shinji Kajimoto, Shinya Tahara, Takakazu Nakabayashi · 2025 · JACS Au
51. Белок FUS: физиологические функции и роль в развитии бокового амиотрофического склероза, "Молекулярная биология"
    A. D. Efimova, Р. К. Овчинников, Andrei Yu. Roman, Andrey V. Maltsev, Владимир Викторович Григорьев, Elena A Kovrazhkina, Veronica I. Skvortsova · 2017 · Molecular Biology
52. Targeting the serotonergic system in the treatment of neurodegenerative diseases—emerging therapies and unmet challenges
    Alina Brüge, Evgeni G. Ponimaskin, Josephine Labus · 2025 · Pharmacological Reviews
53. Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo
    Sukhleen Kour, Tyler R. Fortuna, Eric Nathaniel Anderson, Darilang Mawrie, Jessica Bilstein, Ramakrishnan Sivasubramanian, Caroline Ward, Rishit Roy, Dhivyaa Rajasundaram, Jared L. Sterneckert et al. · 2023 · Nucleic Acids Research
54. Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis
    Michelle Lindström, Beidong Liu · 2018 · Frontiers in Molecular Neuroscience
55. FUS Negatively Regulates Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
    William Dunker, Yu Song, Yang Zhao, John J. Karijolich · 2018 · Viruses
56. BCR–ABL1 kinase-dependent alteration of mRNA metabolism: potential alternatives for therapeutic intervention
    Danilo Perrotti, Jason G. Harb · 2011 · Leukemia & lymphoma/Leukemia and lymphoma
57. Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15
    Jenny Blechingberg, Ida E. Holm, Anders Lade Nielsen · 2011 · Gene
58. Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants
    Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin L. Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen Hans Weishaupt et al. · 2022 · Life Science Alliance
59. Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia
    Miao Sun, Toru Yamashita, Jingwei Shang, Ning Liu, Kentaro Deguchi, Wentao Liu, Yoshio Ikeda, Juan Feng, Koji Abe · 2013 · Journal of Neuroscience Research
60. Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1
    Peter Klint, Ulf Hellman, Christer Wernstedt, Pierre Åman, David Ron, Lena Claesson · 2003 · Cellular Signalling
61. Naphthalene exposure: Effects on gene expression and proliferation in human cord blood cells
    Cristina Diodovich, Ilaria Malerba, Gerard Bowe, Francesco Acquati, Marco Giorgio Bianchi, Roberto Taramelli, D. Parent‐Massin, Laura Gribaldo · 2003 · Journal of Biochemical and Molecular Toxicology
62. RNA sequence and length contribute to RNA-induced conformational change of TLS/FUS
    Nesreen Hamad, Tsukasa Mashima, Yudai Yamaoki, Keiko Kondo, Ryoma Yoneda, Takanori Oyoshi, Riki Kurokawa, Takashi Nagata, Masato Katahira · 2020 · Scientific Reports
63. From the disruption of RNA metabolism to the targeting of RNA ‐binding proteins: The case of polyglutamine spinocerebellar ataxias
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64. Disease Modeling of Rare Neurological Disorders in Zebrafish
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65. Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: Implications for FUS subcellular localization and function
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66. TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5
    Widyawilis Selamat, Ildasolha Jamari, Yu Wang, Toru Takumi, Fulton Wong, Ristuko Fujii · 2008 · Neuroscience Letters
67. Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage
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71. TLS-GFP cannot rescue mRNP formation near spines and spine phenotype in TLS-KO
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72. Cell-Type-Dependent Recruitment Dynamics of FUS Protein at Laser-Induced DNA Damage Sites
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74. The identification of high-performing antibodies for RNA-binding protein FUS for use in Western Blot, immunoprecipitation, and immunofluorescence
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75. Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms
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76. An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome
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79. Liquid–liquid phase separation in neurodegenerative diseases
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80. ALS-linked FUS mutants affect the localization of U7 snRNP and replication-dependent histone gene expression in human cells
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81. Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome
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85. FUS expression alters the differentiation response to all‐trans retinoic acid in NB4 and NB4R2 cells
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86. A C-Terminal Carbohydrate-Binding Domain in the Endothelial Cell Regulatory Protein, Pigpen: New Function for an EWS Family Member
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87. FUS controls the processing of snoRNAs into smaller RNA fragments that can regulate gene expression
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