Ron, David

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 3,310

Perk is essential for translational regulation and cell survival during the unfolded protein response

Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., & Ron, D. (2000) · Molecular Cell

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 2,021

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 1,756

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 1,006

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology

Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease

Cited by 708

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 584

Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cellular Models of Parkinson's Disease

Ryu, E. J., Harding, H. P., Angelastro, J. M., Vitolo, O. V., Ron, D., & Greene, L. A. (2002) · The Journal of Neuroscience

Endoplasmic Reticulum Stress and DiseaseParkinson's Disease Mechanisms and Treatments

Cited by 572

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 509

Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58 IPK

Yan, W., Frank, C. L., Korth, M. J., Sopher, B. L., Novoa, I., Ron, D., & Katze, M. G. (2002) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 385

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

Zinszner, H., Sok, J., Immanuel, D., Yin, Y., & Ron, D. (1997) · Journal of Cell Science

RNA Research and SplicingNuclear Structure and Function

Cited by 350

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Harding, H. P., Zhang, Y., Scheuner, D., Chen, J.-J., Kaufman, R. J., & Ron, D. (2009) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 267

Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

Lin, W., Kemper, A., Dupree, J. L., Harding, H. P., Ron, D., & Popko, B. (2006) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 222

Proteotoxicity in the endoplasmic reticulum: Lessons from the Akita diabetic mouse

Ron, D. (2002) · Journal of Clinical Investigation

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 133

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Cunha, D. A., Igoillo-Esteve, M., Gurzov, E. N., Germano, C. M., Naamane, N., Marhfour, I., Fukaya, M., Vanderwinden, J.-M., Gysemans, C., Mathieu, C., et al. (2012) · Diabetes

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 130

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

Yun, C., Stanhill, A., Yang, Y., Zhang, Y., Haynes, C. M., Xu, C.-F., Neubert, T. A., Mor, A., Philips, M. R., & Ron, D. (2008) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

Cited by 98

Thioredoxin-related Protein 32 Is an Arsenite-regulated Thiol Reductase of the Proteasome 19 S Particle

Wiseman, R. L., Chin, K.-T., Haynes, C. M., Stanhill, A., Xu, C.-F., Roguev, A., Krogan, N. J., Neubert, T. A., & Ron, D. (2009) · Journal of Biological Chemistry

Redox biology and oxidative stressUbiquitin and proteasome pathways

Cited by 46

Membrane biogenesis and the unfolded protein response

Ron, D., & Hampton, R. Y. (2004) · The Journal of Cell Biology

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Cited by 45

De Novo Mutations in EIF2B1 Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction

De Franco, E., Caswell, R., Johnson, M. B., Wakeling, M. N., Zung, A., Dũng, V. C., Bích Ngọc, C. T., Goonetilleke, R., Vivanco Jury, M., El-Khateeb, M., et al. (2020) · Diabetes

Diabetes and associated disordersPancreatic function and diabetes

Cited by 39

Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization

Nobre, L., Wise, D., Ron, D., & Volmer, R. (2015) · PLOS ONE

interferon and immune responsesImmune Response and Inflammation

Cited by 12

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response

Yan, Y., Shetty, M., Harding, H. P., George, G., Zyryanova, A., Labbé, K., Mafi, A., Hao, Q., Sidrauski, C., & Ron, D. (2024) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 7

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

Yan, Y., Shetty, M., Harding, H. P., George, G., Zyryanova, A., Labbé, K., Mafi, A., Hao, Q., Sidrauski, C., & Ron, D. (2023) · Proceedings of the National Academy of Sciences

Endoplasmic Reticulum Stress and DiseaseRNA and protein synthesis mechanisms

Cited by 7