The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases
Abstract
During the past five years, a growing number of serine-threonine kinases highly homologous to the Saccharomyces cerevisiae Ipl1p kinase have been isolated in various organisms. A Drosophila melanogaster homologue, aurora, was the first to be isolated from a multicellular organism. Since then, several related kinases have been found in mammalian cells. They localise to the mitotic apparatus: in the centrosome, at the poles of the bipolar spindle or in the midbody. The kinases are necessary for completion of mitotic events such as centrosome separation, bipolar spindle assembly and chromosome segregation. Extensive research is now focusing on these proteins because the three human homologues are overexpressed in various primary cancers. Furthermore, overexpression of one of these kinases transforms cells. Because of the myriad of kinases identified, we suggest a generic name: Aurora/Ipl1p-related kinase (AIRK). We denote AIRKs with a species prefix and a number, e.g. HsAIRK1.
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Blangy, A., Lane, H. A., d'Hérin, P., Harper, M., Kress, M., & Niggt, E. A. (1995) · Cell · doi:10.1016/0092-8674(95)90142-6 · Cited by 952
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.
Gaglio, T., Saredi, A., Bingham, J. B., Hasbani, M. J., Gill, S. R., Schroer, T. A., & Compton, D. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.2.399 · Cited by 290
Giet, R., Uzbekov, R., Cubizolles, F., Le Guellec, K., & Prigent, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15005 · Cited by 219
Self-citationPoly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development
Paris, J., & Philippe, M. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90070-y · Cited by 142
Cited by
Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1003 · Cited by 965
The Aurora kinases: Role in cell transformation and tumorigenesis
Katayama, H., Brinkley, W. R., & Sen, S. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023789416385 · Cited by 398
Sensing centromere tension: Aurora B and the regulation of kinetochore function
Lampson, M. A., & Cheeseman, I. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.10.007 · Cited by 375
Hutterer, C., Wandinger, S. K., Wagner, S., Müller, R., Stamminger, T., Zeitträger, I., Godl, K., Baumgartner, R., Strobl, S., & Marschall, M. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.04.017 · Cited by 43
Metadata
- Authors
- Giet, R., & Prigent, C.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1999-11-01
- Volume
- 112
- Issue
- 21
- Pages
- 3591-3601
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2276913308
- Cited by
- 314
- References
- 4
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giet, R., & Prigent, C. (1999). Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. Journal of Cell Science. https://doi.org/10.1242/jcs.112.21.3591
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