The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
Abstract
Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion number and decreased cell migration, functions that are regulated by the small GTPase Rho. We now report that fibroblasts from FAK−/− mice failed to transiently inhibit Rho activity when plated on fibronectin. Re-expression of FAK restored normal Rho regulation. Turnover of focal adhesions correlated inversely with Rho activity. The presence or absence of FAK was mimicked by inhibiting or activating Rho, respectively. These data suggest that loss of FAK resulting in constitutive activation of Rho and inhibition of focal adhesion turnover can account for deficiencies in cell migration and embryonic lethality of the FAK knockout.
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Citations
Cites
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
Schlaepfer, D. D., Hanks, S. K., Hunter, T., & Geer, P. V. D. (1994) · Nature · doi:10.1038/372786a0 · Cited by 1,595
Self-citation
Cited by
Focal adhesion kinase: in command and control of cell motility.
Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,335
Self-citationCDK inhibitors: Cell cycle regulators and beyond
Besson, A., Dowdy, S. F., & Roberts, J. M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.013 · Cited by 1,152
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641
Puklin-Faucher, E., & Sheetz, M. P. (2009) · Journal of Cell Science · doi:10.1242/jcs.042127 · Cited by 295
(2002) · PubMed · Cited by 279
Metadata
- Authors
- Ren, X.-D., Kiosses, W. B., Sieg, D. J., Otey, C. A., Schlaepfer, D. D., & Schwartz, M. A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2000-10-15
- Volume
- 113
- Issue
- 20
- Pages
- 3673-3678
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2123305987
- Cited by
- 458
- References
- 1
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ren, X.-D., Kiosses, W. B., Sieg, D. J., Otey, C. A., Schlaepfer, D. D., & Schwartz, M. A. (2000). Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. Journal of Cell Science. https://doi.org/10.1242/jcs.113.20.3673
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
