The actin cytoskeleton of Dictyostelium: a story told by mutants
Abstract
Actin-binding proteins are effectors of cell signalling and coordinators of cellular behaviour. Research on the Dictyostelium actin cytoskeleton has focused both on the elucidation of the function of bona fide actin-binding proteins as well as on proteins involved in signalling to the cytoskeleton. A major part of this work is concerned with the analysis of Dictyostelium mutants. The results derived from these investigations have added to our understanding of the role of the actin cytoskeleton in growth and development. Furthermore, the studies have identified several cellular and developmental stages that are particularly sensitive to an unbalanced cytoskeleton. In addition, use of GFP fusion proteins is revealing the spatial and temporal dynamics of interactions between actin-associated proteins and the cytoskeleton.
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Despite many actin-binding proteins and myosin I isoforms being transiently recruited to phagosomes, only a handful have been shown by gene knock-out experiments to affect phagocytosis, possibly due to redundancy.
“On the other hand, despite many actin-binding proteins and myosin I isoforms are transiently recruited to phagosomes, only a handful of them have been shown by gene knock-out experiments to affect phagocytosis, possibly due to redundancy of the system [4,9,57-59].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [58]
Cites
Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J., & Gerisch, G. (1995) · Cell · doi:10.1016/0092-8674(95)90207-4 · Cited by 354 · see citing works
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Dictyostelium as host model for pathogenesis
Steinert, M., & Heuner, K. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00493.x · Cited by 144 · see citing works
Fajardo, M., Schleicher, M., Noegel, A., Bozzaro, S., Killinger, S., Heuner, K., Hacker, J., & Steinert, M. (2004) · Microbiology · doi:10.1099/mic.0.27111-0 · Cited by 73 · see citing works
Self-citationGenome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium
Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69 · see citing works
- Authors
- Noegel, A. A., & Schleicher, M.
- Affiliations
- University of Cologne (DE)
- Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
- Corresponding author
- Noegel, Angelika A.
- Schleicher, Michael
- ORCID
- Noegel, Angelika A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2000-03-01
- Volume
- 113
- Issue
- 5
- Pages
- 759-766
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2416620668
- Cited by
- 127
- References
- 1
- Citations by year
- 2025: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Slime Mold and Myxomycetes Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- actin cytoskeleton, Dictyostelium, actin-binding proteins, signal transduction, cell growth and development, GFP fusion protein, cell motility
- MeSH terms
- Actins, Animals, Cytoskeleton, Dictyostelium, DNA Mutational Analysis, Humans, Microfilament Proteins, Mutation
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