Dictyostelium as host model for pathogenesis

A kingdom-level phylogeny of eukaryotes based on combined protein data.

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Microorganisms Resistant to Free-Living Amoebae

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Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis

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Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography

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How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.

Tzou, P., Gregorio, E. D., & Lemaître, B. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00294-1 · Cited by 399 · see citing works

Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages

Swanson, M. S., & Hammer, B. K. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.567 · Cited by 382 · see citing works

Differentiate to thrive: lessons from the Legionella pneumophila life cycle

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Legionella Effectors That Promote Nonlytic Release from Protozoa

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Legionella pneumophila: an aquatic microbe goes astray

Steinert, M., Hentschel, U., & Hacker, J. H. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00607.x · Cited by 292 · see citing works

The human pathogen <i>Pseudomonas aeruginosa</i> utilizes conserved virulence pathways to infect the social amoeba <i>Dictyostelium discoideum</i>

Pukatzki, S., Kessin, R. H., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052704399 · Cited by 289 · see citing works

The road less traveled

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Mycobacterium aviumBacilli Grow Saprozoically in Coculture withAcanthamoeba polyphagaand Survive within Cyst Walls

Steinert, M., BIRKNESS, K. A., WHITE, E. H., Fields, B. S., & Quinn, F. D. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.6.2256-2261.1998 · Cited by 274 · see citing works

Pseudomonas aeruginosaVirulence Analyzed in aDictyostelium discoideumHost System

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Common molecular mechanisms of symbiosis and pathogenesis

Hentschel, U., Steinert, M., & Hacker, J. H. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01758-3 · Cited by 250 · see citing works

Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis

Müller‐Taubenberger, A., Lupas, A. N., Li, H., Ecke, M., Simmeth, E., & Gerisch, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6772 · Cited by 242 · see citing works

Unexplored reservoirs of pathogenic bacteria: protozoa and biofilms

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Intracellular Growth of<i>Legionella pneumophila</i>in<i>Dictyostelium discoideum</i>, a System for Genetic Analysis of Host-Pathogen Interactions

Solomon, J. M., Rupper, A., Cardelli, J. A., & Isberg, R. R. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2939-2947.2000 · Cited by 215 · see citing works

The Dictyostelids

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Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella

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Icm/Dot‐dependent upregulation of phagocytosis by Legionella pneumophila

Hilbi, H., Segal, G., & Shuman, H. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02645.x · Cited by 194 · see citing works

Sequence and analysis of chromosome 2 of Dictyostelium discoideum

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RNAi inDictyostelium:The Role of RNA-directed RNA Polymerases and Double-stranded RNase

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Mechanism of phagocytosis in dictyostelium discoideum: phagocytosis is mediated by different recognition sites as disclosed by mutants with altered phagocytotic properties

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Cryptococcus neoformansVirulence Is Enhanced after Growth in the Genetically Malleable HostDictyostelium discoideum

Steenbergen, J. N., Nosanchuk, J. D., Malliaris, S. D., & Casadevall, A. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.4862-4872.2003 · Cited by 156 · see citing works

Phagocytosis and Macropinocytosis in<i>Dictyostelium</i>: Phosphoinositide‐Based Processes, Biochemically Distinct

Cardelli, J. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.002005311.x · Cited by 150 · see citing works

Intracellular Replication of Mycobacterium marinum within Dictyostelium discoideum : Efficient Replication in the Absence of Host Coronin

Solomon, J. M., Leung, G. S., & Isberg, R. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3578-3586.2003 · Cited by 127 · see citing works

The actin cytoskeleton of Dictyostelium: a story told by mutants

Noegel, A. A., & Schleicher, M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.5.759 · Cited by 127 · see citing works

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

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The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

Zink, S. D., Pedersen, L., Cianciotto, N. P., & Kwaik, Y. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1657-1663.2002 · Cited by 123 · see citing works

Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host–pathogen interactions

Solomon, J. M., & Isberg, R. R. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01852-7 · Cited by 112 · see citing works

Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum

Skriwan, C., Fajardo, M., Hägele, S., Horn, M., Wagner, M., Michel, R., Krohne, G., Schleicher, M., Hacker, J., & Steinert, M. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00177 · Cited by 109 · see citing works

Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum

Rupper, A., & Cardelli, J. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00106-4 · Cited by 103 · see citing works

The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens

Bellamy, R. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80010-0 · Cited by 96 · see citing works

Opportunistic Infections of the CNS in Patients with AIDS

Collazos, J. (2003) · CNS Drugs · doi:10.2165/00023210-200317120-00002 · Cited by 84 · see citing works

Disruption of the Phagosomal Membrane and Egress of Legionella pneumophila into the Cytoplasm during the Last Stages of Intracellular Infection of Macrophages and Acanthamoeba polyphaga

Molmeret, M., Bitar, D. M., Han, L., & Kwaik, Y. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4040-4051.2004 · Cited by 79 · see citing works

Biochemical and Functional Analyses of the Mip Protein: Influence of the N-Terminal Half and of Peptidylprolyl Isomerase Activity on the Virulence of Legionella pneumophila

Köhler, R., Fanghänel, J., König, B., Lüneberg, E., Frosch, M., Rahfeld, J., Hilgenfeld, R., Fischer, G. S., Hacker, J. H., & Steinert, M. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4389-4397.2003 · Cited by 76 · see citing works

The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype

Heuner, K., & Steinert, M. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00259 · Cited by 74 · see citing works

DictyosteliumLvsB Mutants Model the Lysosomal Defects Associated with Chediak-Higashi Syndrome

Harris, E. N., Wang, N., Wu, W.-L., Weatherford, A., Lozanne, A. D., & Cardelli, J. A. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-09-0454 · Cited by 73 · see citing works

Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum

Fajardo, M., Schleicher, M., Noegel, A., Bozzaro, S., Killinger, S., Heuner, K., Hacker, J., & Steinert, M. (2004) · Microbiology · doi:10.1099/mic.0.27111-0 · Cited by 73 · see citing works

Influence of the Alternative σ 28 Factor on Virulence and Flagellum Expression of Legionella pneumophila

Heuner, K., Dietrich, C., Skriwan, C., Steinert, M., & Hacker, J. H. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1604-1608.2002 · Cited by 71 · see citing works

Fusion and Fission Events in the Endocytic Pathway of Dictyostelium

Maniak, M. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.40101.x · Cited by 65 · see citing works

Analysis of regulatory networks in Pseudomonas aeruginosa by genomewide transcriptional profiling

Goodman, A. L. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.12.009 · Cited by 65 · see citing works

Cloning and Characterization of the Gene Encoding the Major Cell-Associated Phospholipase A of Legionella pneumophila , plaB , Exhibiting Hemolytic Activity

Flieger, A., Rydzewski, K., Banerji, S., Broich, M., & Heuner, K. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.2648-2658.2004 · Cited by 65 · see citing works

Comparison of the Virulence of Methicillin‐Resistant and Methicillin‐Sensitive Staphylococcus aureus

Mizobuchi, S., Minami, J., Jin, F., Matsushita, O., & Okabe, A. (1994) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1994.tb01829.x · Cited by 49 · see citing works

Crawling into a new era—the Dictyostelium genome project

Eichinger, L., & Noegel, A. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg214 · Cited by 44 · see citing works

Surrogate hosts: protozoa and invertebrates as models for studying pathogen-host interactions

Steinert, M., Leippe, M., & Roeder, T. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00275 · Cited by 37 · see citing works

Loss of the F-Actin Binding and Vesicle-Associated Protein Comitin Leads to a Phagocytosis Defect

Schreiner, T., Mohrs, M. R., Blau‐Wasser, R., von Krempelhuber, A., Steinert, M., Schleicher, M., & Noegel, A. A. (2002) · Eukaryotic Cell · doi:10.1128/ec.1.6.906-914.2002 · Cited by 24 · see citing works

Editorial

Autenrieth, I. B. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00240 · Cited by 19 · see citing works

Mutation of the Dictyostelium fbxA Gene Affects Cell-Fate Decisions and Spatial Patterning

Ennis, H. L., Dao, D. N., Wu, M., & Kessin, R. H. (2003) · Protist · doi:10.1078/143446103322454158 · Cited by 13 · see citing works

Comparison of Probe Preparation Methods for DNA Microarrays

Farbrother, P., Müller, S. C., Noegel, A. A., & Eichinger, L. (2002) · BioTechniques · doi:10.2144/02334mt01 · Cited by 6 · see citing works

Interaction of Legionella pneumophila with Dictyostelium discoideum

Steinert, M., Hägele, S., Skriwan, C., Grimm, D. G., Fajardo, M., Heuner, K., Schleicher, M., Hentschel, U., Ludwig, W., Marre, R., et al. (2014) · ASM Press eBooks · doi:10.1128/9781555817985.ch28 · Cited by 4 · see citing works

Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system

Pukatzki, S. U., Ma, A. T., Sturtevant, D., Krastins, B., Sarracino, D. A., Nelson, W. C., Heidelberg, J. F., & Mekalanos, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510322103 · Cited by 1,116 · see citing works

Current and Past Strategies for Bacterial Culture in Clinical Microbiology

Lagier, J., Edouard, S., Pagnier, I., Mediannikov, O., Drancourt, M., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00110-14 · Cited by 657 · see citing works

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

Newton, H. J., Ang, D. K. Y., van Driel, I. R., & Hartland, E. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-09 · Cited by 493 · see citing works

Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems

Martínez, J. L., Sánchez, M. B., Martínez‐Solano, L., Hernandez, A., Garmendia, L., Fajardo-Lubian, A., & Alvarez‐Ortega, C. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00157.x · Cited by 491 · see citing works

The phagosome: compartment with a license to kill

Haas, A. (2007) · Traffic · doi:10.1111/j.1600-0854.2006.00531.x · Cited by 450 · see citing works

Eat, kill or die: when amoeba meets bacteria

Cosson, P., & Soldati, T. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.05.005 · Cited by 236 · see citing works

Do Free-Living Amoebae in Treated Drinking Water Systems Present an Emerging Health Risk?

Thomas, J., & Ashbolt, N. J. (2010) · Environmental Science & Technology · doi:10.1021/es102876y · Cited by 226 · see citing works

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

Ragaz, C., Pietsch, H., Urwyler, S., Tiaden, A. N., Weber, S. S., & Hilbi, H. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01219.x · Cited by 207 · see citing works

Environmental predators as models for bacterial pathogenesis

Hilbi, H., Weber, S. S., Ragaz, C., Nyfeler, Y., & Urwyler, S. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01238.x · Cited by 197 · see citing works

The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA

Tiaden, A. N., Spirig, T., Weber, S. S., Brüggemann, H., Bosshard, R., Buchrieser, C., & Hilbi, H. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01005.x · Cited by 175 · see citing works

Dictyostelium discoideum—a model for many reasons

Annesley, S. J., & Fisher, P. R. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0111-8 · Cited by 160 · see citing works

Using non-mammalian hosts to study fungal virulence and host defense

Fuchs, B. B., & Mylonakis, E. E. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.06.004 · Cited by 151 · see citing works

Free-living amoebae, a training field for macrophage resistance of mycobacteria

Salah, I. B., Ghigo, É., & Drancourt, M. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.03011.x · Cited by 145 · see citing works

Mycobacterium marinum: ubiquitous agent of waterborne granulomatous skin infections

Petrini, B. (2006) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-006-0201-4 · Cited by 142 · see citing works

From Grazing Resistance to Pathogenesis: The Coincidental Evolution of Virulence Factors

Adiba, S., Nizak, C., van Baalen, M., Denamur, É., & Depaulis, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011882 · Cited by 136 · see citing works

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth ofLegionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE

Weber, S. S., Ragaz, C., & Hilbi, H. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01266.x · Cited by 133 · see citing works

A Novel Sensor Kinase-Response Regulator Hybrid Controls Biofilm Formation and Type VI Secretion System Activity in Burkholderia cenocepacia

Aubert, D., Flannagan, R. S., & Valvano, M. A. (2008) · Infection and Immunity · doi:10.1128/iai.01338-07 · Cited by 132 · see citing works

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

Biggins, J. B., Ternei, M. A., & Brady, S. F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3052156 · Cited by 125 · see citing works

Towards a molecular understanding of human diseases using Dictyostelium discoideum

Williams, R. S. B., Boeckeler, K., Gräf, R., Müller‐Taubenberger, A., Li, Z., Isberg, R. R., Wessels, D. J., Soll, D. R., Alexander, H., & Alexander, S. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.07.003 · Cited by 123 · see citing works

The Professional Phagocyte Dictyostelium discoideum as a Model Host for Bacterial Pathogens

Bozzaro, S., & Eichinger, L. (2011) · Current Drug Targets · doi:10.2174/138945011795677782 · Cited by 120 · see citing works

Genomic and Functional Analysis of the Type VI Secretion System in Acinetobacter

Weber, B. S., Miyata, S. T., Iwashkiw, J. A., Mortensen, B. L., Skaar, E. P., Pukatzki, S. U., & Feldman, M. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055142 · Cited by 117 · see citing works

Free-living amoebae and squatters in the wild: ecological and molecular features

Samba‐Louaka, A., Delafont, V., Rodier, M., Cateau, E., & Héchard, Y. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz011 · Cited by 116 · see citing works

Burkholderia bacteria infectiously induce the proto-farming symbiosis of Dictyostelium amoebae and food bacteria

DiSalvo, S., Haselkorn, T. S., Bashir, U., Jimenez, D., Brock, D. A., Queller, D. C., & Strassmann, J. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511878112 · Cited by 113 · see citing works

Dictyostelium transcriptional host cell response upon infection with Legionella

Farbrother, P., Wagner, C., Na, J., Tunggal, B., Morio, T., Urushihara, H., Tanaka, Y., Schleicher, M., Steinert, M., & Eichinger, L. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00633.x · Cited by 112 · see citing works

Legionella spp. outdoors: colonization, communication and persistence

Hilbi, H., Hoffmann, C., & Harrison, C. F. (2011) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2011.00247.x · Cited by 107 · see citing works

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection

Swart, A. L., Harrison, C. F., Eichinger, L., Steinert, M., & Hilbi, H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00061 · Cited by 105 · see citing works

Legionella pathogenicity: Genome structure, regulatory networks and the host cell response

Steinert, M., Heuner, K., Buchrieser, C., Albert-Weißenberger, C., & Glöckner, G. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.03.009 · Cited by 105 · see citing works

Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila

Tung, S. M., Ünal, C., Ley, A., Peña, C., Tunggal, B., Noegel, A. A., Krut, O., Steinert, M., & Eichinger, L. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01432.x · Cited by 104 · see citing works

Live-Cell Imaging of Phosphoinositide Dynamics and Membrane Architecture during Legionella Infection

Weber, S., Wagner, M. A., & Hilbi, H. (2014) · mBio · doi:10.1128/mbio.00839-13 · Cited by 101 · see citing works

Proteomics Fingerprinting of Phagosome Maturation and Evidence for the Role of a Gα during Uptake

Gotthardt, D., Blancheteau, V., Bosserhoff, A., Ruppert, T., Delorenzi, M., & Soldati, T. (2006) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m600113-mcp200 · Cited by 98 · see citing works

Type VI Secretion Effectors: Methodologies and Biology

Lien, Y., & Lai, E. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00254 · Cited by 98 · see citing works

Autophagy in Dictyostelium: Genes and pathways, cell death and infection

Calvo‐Garrido, J., Carilla-Latorre, S., Kubohara, Y., Santos-Rodrigo, N., Mesquita, A., Soldati, T., Golstein, P., & Escalante, R. (2010) · Autophagy · doi:10.4161/auto.6.6.12513 · Cited by 97 · see citing works

Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics

Steiner, B., Weber, S., & Hilbi, H. (2017) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2017.08.004 · Cited by 94 · see citing works

Chapter 6 Phagocytosis and Host–Pathogen Interactions in Dictyostelium with a Look at Macrophages

Bozzaro, S., Bucci, C., & Steinert, M. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01206-9 · Cited by 94 · see citing works

Animal models: an important tool in mycology

Capilla, J., Clemons, K. V., & Stevens, D. A. (2007) · Medical Mycology · doi:10.1080/13693780701644140 · Cited by 94 · see citing works

Dictyostelium Finds New Roles to Model

Williams, J. G. (2010) · Genetics · doi:10.1534/genetics.110.119297 · Cited by 90 · see citing works

Pathogen–host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens

Steinert, M. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.11.003 · Cited by 89 · see citing works

Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium

Shevchuk, O., Batzilla, C. F., Hägele, S., Kusch, H., Engelmann, S., Hecker, M., Haas, A., Heuner, K., Glöckner, G., & Steinert, M. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.03.006 · Cited by 87 · see citing works

The Cold War of the Social Amoebae

Shaulsky, G., & Kessin, R. H. (2007) · Current Biology · doi:10.1016/j.cub.2007.06.024 · Cited by 84 · see citing works

Anchors for Effectors: Subversion of Phosphoinositide Lipids by Legionella

Hilbi, H., Weber, S., & Finsel, I. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00091 · Cited by 83 · see citing works

Modulation of phosphoinositide metabolism by pathogenic bacteria

Hilbi, H. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00793.x · Cited by 80 · see citing works

Autophagy in Inflammatory Diseases

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Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium

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