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Characterization of nuclear structures containing superhelical DNA
Abstract
Structures resembling nuclei but depleted of protein may be released by gently lysing cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids sediment in gradients containing intercalating agents in a manner characteristic of DNA that is intact, supercoiled and circular. The concentration of salt present during isolation of human nucleoids affects their protein content. When made in 1·95 M NaCl they lack histones and most of the proteins characteristic of chromatin; in 1·0 M NaCl they contain variable amounts of histones. The effects of various treatments on nucleoid integrity were investigated.
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Cited by
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The comet assay: what can it really tell us?
Collins, A. R., Dobson, V. L., Dušinská, M., Kennedy, G., & Štětina, R. (1997) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(97)00013-4 · Cited by 668
Gene functioning and storage within a folded genome
Razin, S. V., & Ulianov, S. V. (2017) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-017-0050-4 · Cited by 37
Metadata
- Authors
- Cook, P. R., Brazell, I. A., & JOst, E.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1976-11-01
- Volume
- 22
- Issue
- 2
- Pages
- 303-324
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1818252956
- Cited by
- 368
- References
- 0
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Characterization of nuclear structures containing superhelical DNA. https://app.cochat.ai/papers/10.1242/jcs.22.2.303
- The paper
- Cook, P. R., Brazell, I. A., & JOst, E. (1976). Characterization of nuclear structures containing superhelical DNA. Journal of Cell Science. https://doi.org/10.1242/jcs.22.2.303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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