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Cited by 519Physiological and biochemical adaptationsThermal Regulation in MedicineHigh Altitude and Hypoxia

Mechanisms of cell survival in hypoxia and hypothermia

Boutilier, R. G.·2001·Journal of Experimental Biology
DOI 10.1242/jeb.204.18.3171
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Abstract

SUMMARY: Most animals experience some degree of hypoxia and hypothermia during the course of their natural life history either as a consequence of ambient ‘exposure’ per se or through metabolic, respiratory and/or circulatory insufficiency. A prevailing experimental approach has been to probe tissues from natural models of hypoxia-tolerant and cold-tolerant vertebrates to look for common mechanisms of defence against O2 lack and hypothermia. The ability to sustain vital cellular functions in severe cases of either condition varies widely amongst the vertebrates. Like humans, the vast majority of mammals are unable to survive prolonged periods of hypothermia or O2 deprivation owing to irreversible membrane damage and loss of cellular ion homeostasis in vital organs such as the brain and heart. However, numerous hibernating endotherms, neonatal and diving mammals as well as many ectotherms can tolerate prolonged periods that would, in clinical terms, be called asphyxia or deep hypothermia. The key to their survival under such conditions lies in an inherent ability to downregulate their cellular metabolic rate to new hypometabolic steady states in a way that balances the ATP demand and ATP supply pathways.

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  • Mitochondria are essential regulators of cellular bioenergetics that respond to changes in environmental stimuli such as hormones, nutrients, and oxygen tension.

    “Mitochondria are essential regulators of cellular bioenergetics that respond to changes in environmental stimuli, such as hormones, nutrients, and oxygen tension (47, 94, 99, 109, 290, 301, 385).”

    From Redox regulation of mitochondrial function (2012) · cites this paper as [47]

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Authors
Boutilier, R. G.
Affiliations
University of Cambridge (GB)
Corresponding author
Boutilier, R. G.
ORCID
Boutilier, R. G.
Venue
Journal of Experimental Biology
Publisher
The Company of Biologists
Published
2001-09-15
Volume
204
Issue
18
Pages
3171-3181
ISSN
  • 0022-0949 (ISSN-L)
  • 1477-9145
DOI
10.1242/jeb.204.18.3171
OpenAlex
W2168102799
Cited by
519
References
93
Citations by year
2026: 7 · 2025: 22 · 2024: 20 · 2023: 17 · 2022: 14 · 2021: 30 · 2020: 28 · 2019: 23 · 2018: 28 · 2017: 31 · 2016: 31 · 2015: 29 · 2014: 27 · 2013: 27 · 2012: 16
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Experimental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
Keywords
hypoxia, hypothermia, cell survival, hypometabolism, oxygen deprivation, deep hypothermia, hibernation, diving mammals, ectotherms, ion homeostasis, membrane damage, cold tolerance, hypoxia tolerance
MeSH terms
Adaptation, Physiological, Adenosine Triphosphate, Animals, Hypoxia, Basal Metabolism, Cell Survival, Energy Metabolism, Humans, Hypothermia, Mitochondria

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