Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization
Abstract
Background To analyze predictive factors of hypertrophy of the nonembolized future remnant liver (FRL) after transhepatic preoperative portal vein embolization (PVE) of the liver to be resected.Materials and methods Age, gender, indocyanin green clearance test, chemotherapy before PVE, type of chemotherapy, operators, extent of PVE, radiofrequency ablation (RFA) associated with PVE, time delay between PVE and surgery, and platelet count were retrospectively evaluated as predictive factors for hypertrophy of FRL in 107 patients with malignant disease in noncirrhotic liver. PVE targeted the right liver lobe [n = 70] or the right liver lobe and segment IV [n = 37] when FRL/total liver volume ratio was below 25% in healthy liver or 40% in altered liver.Results After PVE, FRL volume significantly increased by 69%, from 344 +/- 156 cm(3) to 543 +/- 192 cm(3) (P < .0001). The degree of hypertrophy was negatively correlated with FRL volume (correlation coefficient = -0.55, P < .0001) and FRL/TFL ratio (correlation coefficient = -0.52, P < .0001) before PVE. Patients, who have undergone chemotherapy with platin agents prior to PVE, demonstrated lower hypertrophy (P = .048).Conclusion Hypertrophy after PVE is inversely correlated to initial FRL volume. Hypertrophy of the liver might be influenced by the systemic chemotherapeutic received before PVE.
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Predictors of response to TACE were a size of <3 cm and high lipidol uptake.
“Predictors of response were a size of <3 cm and high lipidol uptake.”
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In the largest series to date, 103 lesions in 29 patients were treated with TACE with response in 21% of patients and stabilization in 62%.
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From Adrenocortical carcinoma (2014) · cites this paper as [357]
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- Authors
- de Baere, T., Teriitehau, C., Deschamps, F., Catherine, L., Rao, P., Hakime, A., Auperin, A., Goere, D., Elias, D., & Hechelhammer, L.
- Affiliations
- Institut Gustave Roussy (FR)
- Venue
- Annals of Surgical Oncology
- Published
- 2010-03-17
- Volume
- 17
- Issue
- 8
- Pages
- 2081-2089
- ISSN
- 1068-9265 (ISSN-L)
- 1534-4681
- OpenAlex
- W2082993378
- Cited by
- 139
- References
- 43
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 8 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Annals of Surgical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- liver hypertrophy, predictive factors, hepatectomy, non-cirrhotic liver, neoadjuvant chemotherapy, platinum agents, indocyanine green clearance, radiofrequency ablation
- MeSH terms
- Adolescent, Adult, Aged, Embolization, Therapeutic, Female, Hepatectomy, Humans, Hypertrophy, Liver, Liver Neoplasms, Male, Middle Aged, Portal Vein, Retrospective Studies, Treatment Outcome, Young Adult
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