Efficient and Homochiral Selective Oligomerization of Racemic Ribonucleotides on Mineral Surface
Abstract
We have found that activated racemic mononucleotides oligomerize with comparable efficiency to chiral d-monomers on Na+-montmorillonite, and that the reaction proceeds in a homochiral selective manner to preferentially give optically homogeneous d- and l-oligomers. Mineral surfaces might play important roles in an early stage of chemical evolution of RNAs.
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The distribution of oligomer stereoisomers appeared to be biased in favour of homochiral sequences.
“The distribution of oligomer stereoisomers (up to 8 units under these conditions) appeared to be biased in favour of homochiral sequences.”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [534]
Activated racemic adenosine oligomerized with comparable efficiency to enantiopure D-monomers discarding significant enantiomeric crossinhibition.
“Activated racemic adenosine oligomerized with comparable efficiency to enantiopure D-monomers discarding significant enantiomeric crossinhibition.”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [534]
Cites
Chiral selection in poly(C)-directed synthesis of oligo(G)
Joyce, G. F., Visser, G. M., van Boeckel, C. A. A., van Boom, J. H., Orgel, L. E., & van Westrenen, J. (1984) · Nature · doi:10.1038/310602a0 · Cited by 398 · see citing works
Non-enzymatic template-directed synthesis on RNA random copolymers
Joyce, G. F., Inoue, T., & Orgel, L. E. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90425-x · Cited by 178 · see citing works
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Possible chemical and physical scenarios towards biological homochirality
Sallembien, Q., Bouteiller, L., Crassous, J., & Raynal, M. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01179k · Cited by 186 · see citing works
Selectivity of montmorillonite catalyzed prebiotic reactions of D, L-nucleotides
Joshi, P. C., Pitsch, S., & Ferris, J. P. (2007) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-006-9013-x · Cited by 43 · see citing works
- Authors
- Urata, H., Aono, C., Ohmoto, N., Shimamoto, Y., Kobayashi, Y., & Akagi, M.
- Affiliations
- Osaka University of Pharmaceutical Sciences (JP)
- Venue
- Chemistry Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04-01
- Volume
- 30
- Issue
- 4
- Pages
- 324-325
- ISSN
- 0366-7022 (ISSN-L)
- 1348-0715
- OpenAlex
- W2011693949
- Cited by
- 16
- References
- 2
- Citations by year
- 2022: 1 · 2019: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemistry Letters (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- sodium montmorillonite, clay minerals, mineral surfaces, chemical evolution
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