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Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens.
Open accessAbstract
Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-alpha production. We also found that PLE suppressed the tumor necrosis factor-alpha (TNF-alpha) production in vitro. Using the inhibitory activity of TNF-alpha production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-alpha production, inhibition of arachidonic acid-induced ear edema, inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla.
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Cited by
Distribution and biological activities of the flavonoid luteolin
Lopez-Lazaro, M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709787001712 · Cited by 1,106
BANNO, N., AKIHISA, T., TOKUDA, H., YASUKAWA, K., HIGASHIHARA, H., UKIYA, M., WATANABE, K., KIMURA, Y., HASEGAWA, J.-I., & NISHINO, H. (2004) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.68.85 · Cited by 261
Metadata
- Authors
- Ueda, H., Yamazaki, C., & Yamazaki, M.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2002
- Volume
- 25
- Issue
- 9
- Pages
- 1197-1202
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2044558869
- Cited by
- 290
- References
- 0
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ueda, H., Yamazaki, C., & Yamazaki, M. (2002). Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens. Biological and Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.25.1197
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