The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
Abstract
Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.
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Citations
Cites
Pharmacology of oleanolic acid and ursolic acid
Liu, J. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)90032-2 · Cited by 1,429
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Huang, M.-N., Ho, C., Wang, Z. Y., Ferraro, T., Lou, Y. R., Stauber, K. L., Ma, W., Georgiadis, C. A., Laskin, J. D., & Conney, A. H. (1994) · PubMed · Cited by 548
Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens.
Ueda, H., Yamazaki, C., & Yamazaki, M. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.1197 · Cited by 290
Tokuda, H., Ohigashi, H., Koshimizu, K., & Ito, Y. (1986) · Cancer Letters · doi:10.1016/0304-3835(86)90067-4 · Cited by 249
Self-citationOhigashi, H., Takamura, H., Koshimizu, K., Tokuda, H., & Ito, Y. (1986) · Cancer Letters · doi:10.1016/0304-3835(86)90082-0 · Cited by 160
Self-citationInhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation
Takaishi, Y., Ujita, K., Tokuda, H., Nishino, H., Iwashima, A., & Fujita, T. (1992) · Cancer Letters · doi:10.1016/0304-3835(92)90208-d · Cited by 112
Self-citationInhibitory Effect of Perilla Leaf Extract and Luteolin on Mouse Skin Tumor Promotion.
Ueda, H., Yamazaki, C., & Yamazaki, M. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.560 · Cited by 96
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Self-citationYasukawa, K., Akihisa, T., Oinuma, H., et al. (2009) · Oncology · doi:10.1159/000227584 · Cited by 53
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Cited by
Defined plant extracts can protect human cells against combined xenobiotic effects
Gasnier, C., Laurant, C., Decroix-Laporte, C., Mesnage, R., Clair, E., Travert, C., & Séralini, G.-E. (2011) · Journal of Occupational Medicine and Toxicology · doi:10.1186/1745-6673-6-3 · Cited by 31
Metadata
- Authors
- BANNO, N., AKIHISA, T., TOKUDA, H., YASUKAWA, K., HIGASHIHARA, H., UKIYA, M., WATANABE, K., KIMURA, Y., HASEGAWA, J.-I., & NISHINO, H.
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 68
- Issue
- 1
- Pages
- 85-90
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2015012586
- Cited by
- 261
- References
- 11
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects. https://app.cochat.ai/papers/10.1271/bbb.68.85
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- BANNO, N., AKIHISA, T., TOKUDA, H., YASUKAWA, K., HIGASHIHARA, H., UKIYA, M., WATANABE, K., KIMURA, Y., HASEGAWA, J.-I., & NISHINO, H. (2004). Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects. Bioscience, Biotechnology, and Biochemistry. https://doi.org/10.1271/bbb.68.85
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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