Fucoidan inhibits UVB-induced MMP-1 expression in human skin fibroblasts
Open accessAbstract
Ultraviolet (UV)B irradiation induces the production of matrix metalloproteinases (MMPs) by activating cellular signaling transduction pathways, which are responsible for the degradation or synthesis inhibition of collagenous extracellular matrix in connective tissues, causing skin photoaging. Using the human skin fibroblast (HS68) cell line in the present study, we investigated the inhibitory effects of fucoidan on MMP-1 expression by various in vitro experiments and elucidated the pathways of inhibition. Pretreatment with fucoidan inhibited UVB-induced MMP-1 expression in a dose-dependent manner. Extracellular signal regulated kinase (ERK) activation was markedly inhibited by treatment with fucoidan, though JNK activation was very slightly affected by fucoidan. We also found that fucoidan pretreatment significantly reduced MMP-1 mRNA expression in comparison with UVB irradiation only. In conclusion, our results demonstrate that fucoidan can mainly inhibit UVB-induced MMP-1 expression by inhibiting the ERK pathways. Therefore, fucoidan might be used as a potential agent for the prevention and treatment of skin photoaging.
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Fucoidans inhibited MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.
“They inhibited significantly MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [69]
Fucoidans suppressed UVB-induced MMP-1 expression and inhibited ERK activity in human skin fibroblasts in a dose-dependent manner.
“Fucoidans suppressed the UVB induced MMP-1 expression and inhibited ERKs activity in human skin fibroblasts in a dose-dependent manner.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [69]
Costaria costata fucoidan may be considered a potential agent for prevention and treatment of skin photoaging.
“It was concluded that Costaria costata fucoidan may be considered as a potential agent for the prevention and treatment of skin photoaging [68,69,70].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [69]
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References 25 · Cited by 131
Research works printed but not linked: 1
- Springman E. B., Angleton E. L., Birkedal-Hansen H., Van Wart H. E., Proc. Natl. Acad. Sci. U.S.A., 87, 364-368 (1990).
- Authors
- Moon, H. J., Lee, S. R., Shim, S. N., Jeong, S. H., Stonik, V. A., Rasskazov, V. A., Zvyagintseva, T., & Lee, Y. H.
- Affiliations
- Kosin University (KR)
- Pacific Institute of Bioorganic Chemistry of Far East Branch of the Russian Academy of Sciences
- Russian Academy of Sciences (RU)
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2008
- Volume
- 31
- Issue
- 2
- Pages
- 284-289
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2077735637
- Cited by
- 131
- References
- 25
- Citations by year
- 2026: 1 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 11 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- fucoidan, UVB irradiation, MMP-1, photoaging, dermal fibroblasts, ERK signaling, JNK signaling, collagen degradation, extracellular matrix
- MeSH terms
- Cell Line, Cell Survival, Fibroblasts, Humans, Polysaccharides, Radiation-Protective Agents, RNA, Messenger, Skin, Tetrazolium Salts, Thiazoles, Ultraviolet Rays, Blotting, Western, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 1, JNK Mitogen-Activated Protein Kinases, Extracellular Signal-Regulated MAP Kinases
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