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Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
Open accessAbstract
Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.
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“Under in vitro conditions, withanolide A and withanosides IV and VI were found to have a role in the extension of axons and dendrites [165].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [165]
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Metadata
- Authors
- Kuboyama, T., Tohda, C., & Komatsu, K.
- Affiliations
- University of Toyama (JP)
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2014
- Volume
- 37
- Issue
- 6
- Pages
- 892-897
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2129664426
- Cited by
- 127
- References
- 58
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 20 · 2022: 16 · 2021: 17 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 6
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Institute of Natural Medicine, University of Toyama
- Japan Society for the Promotion of Science (23700376, 23500439)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacological Effects of Medicinal Plants
- Keywords
- Withania somnifera, neurodegenerative diseases, Alzheimer's disease, spinal cord injury, Ayurveda, neuroprotective activity, traditional medicine, plant extracts
- MeSH terms
- Alzheimer Disease, Humans, Medicine, Ayurvedic, Plant Extracts, Spinal Cord Injuries, Molecular Structure, Plant Roots, Neuroprotective Agents, Neurodegenerative Diseases, Withania
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