Neurodegenerative diseases and Withania somnifera (L.): An update

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Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study

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Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

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Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

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Efficacy and Safety of Ashwagandha ( <i>Withania somnifera</i> (L.) <i>Dunal</i> ) Root Extract in Improving Memory and Cognitive Functions

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Withania somnifera Alleviates Parkinsonian Phenotypes by Inhibiting Apoptotic Pathways in Dopaminergic Neurons

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An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

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Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities.

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Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

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Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha

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Association of l-DOPA with recovery following Ayurveda medication in Parkinson’s disease

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Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse

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Effect of ashwagandha on lipid peroxidation in stress-induced animals

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Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha

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Pael‐R is accumulated in Lewy bodies of Parkinson's disease

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Withanamides in <i>Withania somnifera</i> fruit protect PC‐12 cells from β‐amyloid responsible for Alzheimer's disease

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Ashwagandha leaf extract: A potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease

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Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

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Randomized Placebo-Controlled Adjunctive Study of an Extract ofWithania somniferafor Cognitive Dysfunction in Bipolar Disorder

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Possible Neuroprotective Effect of <i>Withania somnifera</i> Root Extract Against 3-Nitropropionic Acid-Induced Behavioral, Biochemical, and Mitochondrial Dysfunction in an Animal Model of Huntington's Disease

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Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

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The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: An analysis of behavioral and biochemical varibles

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Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

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Effects of glycowithanolides from <i>Withania somnifera</i> on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats

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Withanolide A Prevents Neurodegeneration by Modulating Hippocampal Glutathione Biosynthesis during Hypoxia

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W ithania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis

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Effect of standardized aqueous extract of Withania somniferaon tests of cognitive and psychomotor performance in healthy human participants

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Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice

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Withania somnifera root extract ameliorates hypobaric hypoxia induced memory impairment in rats

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Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats

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In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β‐amyloid(1–42)‐induced cytotoxicity in differentiated PC12 cells

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Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells

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Augmentation and proliferation of T lymphocytes and Th-1 cytokines by Withania somnifera in stressed mice

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Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway

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Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.

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Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

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Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation

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Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis

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Prenatal developmental toxicity evaluation of Withania somnifera root extract in Wistar rats

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Effect of Withania somnifera Supplementation on Rotenone-Induced Oxidative Damage in Cerebellum and Striatum of the Male Mice Brain

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A biologically active constituent of withania somnifera (ashwagandha) with antistress activity

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Propoxur-induced acetylcholine esterase inhibition and impairment of cognitive function: attenuation by Withania somnifera.

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Comparative antioxidant potential of Withania somnifera based herbal formulation prepared by traditional and non-traditional fermentation processes

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β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A

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Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment

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In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera

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Blood-Brain Barrier Permeability of Bioactive Withanamides Present in Withania somnifera Fruit Extract

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Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats

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Withania somnifera: a pre-clinical study on neuroregenerative therapy for stroke

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Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice

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Effects of root extract of withania somnifera in 3- nitropropionic acid-induced cognitive dysfunction and oxidative damage in rats

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A STUDY ON THE BEHAVIOUR OF HUNTINGTON’S CHOREA RAT MODELS ON ROTAROD: TREATED WITH WITHANOLIDE A AND THE ETHANOLIC EXTRACT OF WITHANIA SOMNIFERA

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Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

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An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)

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Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

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Can Ashwagandha Benefit the Endocrine System?—A Review

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Kalachaveedu, M., Senthilnathan, R. D., Azhagiyamanavalan, S., Ravi, R., Meenakshisundaram, H., & Dharmarajan, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7747 · Cited by 37 · see citing works

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Joshi, T., Kumar, V., Kaznacheyeva, E. V., & Jana, N. R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02397-8 · Cited by 34 · see citing works

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Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works

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Wang, J., Zhang, H., Kaul, A., Li, K., Priyandoko, D., Kaul, S. C., & Wadhwa, R. (2021) · Biomolecules · doi:10.3390/biom11101454 · Cited by 30 · see citing works

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Singirala, S. K., Dubey, P. K., & Roy, S. (2025) · International Journal of Food Science · doi:10.1155/ijfo/9922626 · Cited by 28 · see citing works

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Behl, T., Kaur, G., Sehgal, A., Singh, S., Bhatia, S., Al‐Harrasi, A., Zengin, G., BUNGAU, S. G., Munteanu, M. A., Brisc, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084045 · Cited by 24 · see citing works

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Goel, F. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01794-y · Cited by 29 · see citing works

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Nascimento, I. J. D. S., da Silva‐Júnior, E. F., & de Aquino, T. M. (2021) · Current Drug Targets · doi:10.2174/1389450122666210809090909 · Cited by 22 · see citing works

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Dhuli, K., Naureen, Z., Medori, M. C., Caruso, P., Manganotti, P., Chiurazzi, P., & Bertelli, M. (2022) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2022.63.2s3.2759 · Cited by 25 · see citing works

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Khalid, M. U., Sultan, M. T., Baig, I., Abbas, A., Noman, A. M., Zinedine, A., Bartkienė, E., & Rocha, J. M. (2025) · Natural Product Research · doi:10.1080/14786419.2025.2499070 · Cited by 18 · see citing works

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Shukla, R., Pahal, S., Gupta, A., Choudhary, P., Misra, K., & Singh, S. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2068072 · Cited by 18 · see citing works

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Holvoet, H., Long, D. M., Law, A. D., McClure, C., Choi, J., Yang, L., Marney, L. C., Poeck, B., Strauß, R., Stevens, J. F., et al. (2022) · Nutrients · doi:10.3390/nu14193923 · Cited by 18 · see citing works

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Ramli, S., Wu, Y. S., Batumalaie, K., Guad, R. M., Choy, K. W., Kumar, A., Gopinath, S. C. B., Sarker, M. M. R., Subramaniyan, V., Sekar, M., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11041000 · Cited by 16 · see citing works

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Ko, J.-S., Chang, B., Choi, Y., Choi, J., Kwon, H., Lee, J., Kim, S.-Y., & Choung, S. (2024) · Nutrients · doi:10.3390/nu16010157 · Cited by 18 · see citing works

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Jadaun, J. S., Yadav, R., Yadav, N., Bansal, S., & Sangwan, N. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_12 · Cited by 14 · see citing works

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Abolarin, P. O., Amin, A., Nafiu, A. B., Ogundele, O. M., & Owoyele, B. V. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2024.05.011 · Cited by 20 · see citing works

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Ghosh, S., Debnath, I., Bhunia, S., Nandi, S., Ashique, S., Nayak, A., Mallick, S., & Basak, S. (2025) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2025.09.005 · Cited by 15 · see citing works

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Cabey, K., Long, D. M., Law, A. D., Gray, N. E., McClure, C., Caruso, M. A., Lak, P., Wright, K. M., Stevens, J. F., Maier, C. S., et al. (2022) · Antioxidants · doi:10.3390/antiox11010121 · Cited by 13 · see citing works

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Ghosh, S., Singha, P. S., & Ghosh, D. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00030 · Cited by 13 · see citing works

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Panda, S. M., Nandeshwar, N., & Tripathy, U. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136977 · Cited by 11 · see citing works

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Speers, A. B., Lozano-Ortiz, A., & Soumyanath, A. (2024) · Nutrients · doi:10.3390/nu16223836 · Cited by 14 · see citing works

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Khandia, R., Viswanathan, N., Singhal, S., Alqahtani, T., Almikhlafi, M. A., Simonov, A. N., & Ashraf, G. M. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220610155608 · Cited by 11 · see citing works

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Acero, N., Ortega, T., Villagrasa, V., Leon, G., Mingarro, D. M., Castillo, E., González‐Rosende, M. E., Borrás, S., Rı́os, J. L., Bosch‐Morell, F., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7727 · Cited by 13 · see citing works

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Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2025) · Molecules · doi:10.3390/molecules30040922 · Cited by 13 · see citing works

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Faisal, A. F., & Mustafa, Y. F. (2025) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-025-01317-0 · Cited by 10 · see citing works

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Zou, M., Chen, F., Deng, L.-R., Han, Q., Huang, C.-Y., Shen, S.-S., Tomlinson, B., & Li, Y.-H. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175185 · Cited by 9 · see citing works

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Vashisth, M. K., Hu, J., Liu, M., Basha, S. H., Chen, Y., & Huang, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-78975-2 · Cited by 8 · see citing works

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Sharma, S., Kochhar, K. P., Jain, S., Jayasundar, R., & Divya, M. R. (2021) · Annals of Phytomedicine An International Journal · doi:10.21276/ap.2021.10.2.34 · Cited by 7 · see citing works

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de Melo, A., de Melo, A. L., Marcucci, M. C., de Carvalho, C., & Gonçalves, C. P. (2021) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2021.10.00369 · Cited by 8 · see citing works

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Parrales, V., Arcile, G., Laserre, L., Normant, S., Goff, G. L., Noble, C. D. C., Ouazzani, J., Callizot, N., Haı̈k, S., Rabhi, C., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00655 · Cited by 7 · see citing works

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Doke, R. R., Kallur, S., Suryawanshi, A. P., Utarade, A., Kandalkar, P., Morde, R., & Bhagwat, A. A. (2023) · IP International Journal of Comprehensive and Advanced Pharmacology · doi:10.18231/j.ijcaap.2023.026 · Cited by 6 · see citing works

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Soliman, M. M., El‐Shehawi, A. M., Althobaiti, S. A., & Sayed, S. M. H. (2023) · Toxicology Research · doi:10.1093/toxres/tfad058 · Cited by 5 · see citing works

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Muralidhara, M., & Rajini, P. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00002-8 · Cited by 4 · see citing works

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Beebe, S. E. (2023) · doi:10.1002/9781119823551.ch9 · Cited by 5 · see citing works

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Barr, S. A., Davis, L. J., Vidar, W. S., Williamson, R. T., & Strangman, W. K. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09897 · Cited by 4 · see citing works

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Singh, A., Mazumder, A., Das, S., Kanda, A., Mishra, R., & Chaitanya, M. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072311552240718112619 · Cited by 4 · see citing works

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Chakraborty, P., Pal, S., Galstyan, D. S., Petersen, E. V., Amstislavskaya, T. G., Kolesnikova, T. O., de Abreu, M. S., & Kalueff, A. V. (2025) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2025.101169 · Cited by 4 · see citing works

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Haxhiu, H., Hoxha, M., Zela, I., & Zappacosta, B. (2025) · Biomedicines · doi:10.3390/biomedicines13082008 · Cited by 6 · see citing works

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Yoshitomi, R., Nanda, R., Hirano, K., Kaul, S. C., Dhanjal, J. K., & Wadhwa, R. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112126 · Cited by 3 · see citing works

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Rajalakshmi, M., Indu, S., & Vijayalakshmi, P. (2024) · Springer eBooks · doi:10.1007/978-981-99-7269-2_5 · Cited by 3 · see citing works

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Effect of nitrogen nutrition on water-deficit stress tolerance potential of Withania somnifera (L.) Dunal

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Sabry, M. O., Seleem, M. M., Ebrahim, Y. M., Hussien, S. G., Ahmed, R. H. H., Hassan, H. E., Bahr, A., Alsadany, M. A., El‐Shiekh, R. A., & Ali, D. E. (2025) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-025-00729-6 · Cited by 3 · see citing works

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Srivastava, A. N., Ahamad, T., Sarfraz, A., Siddiqui, S., Khan, F., Trivedi, A., Khan, M. F., Misra, A., Shankar, H., Khan, M. A., et al. (2026) · Cytoskeleton · doi:10.1002/cm.70131 · Cited by 2 · see citing works

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Malhotra, S., & Sandhir, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19084-1.00013-2 · Cited by 2 · see citing works

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Jhooty, S., Barkhaus, P. E., Brown, A. D., Cadavid, J. M., Carter, G. T., Crayle, J. I., Heiman-Patterson, T. D., Li, X., Mallon, E., McDermott, C. J., et al. (2024) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2024.2311721 · Cited by 2 · see citing works

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Dhillon, D., Jain, M., Singh, A. K., & Muthukumaran, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151383 · Cited by 2 · see citing works

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