The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application
Open accessAbstract
Exosomes are cell-derived vesicles with a diameter 30-120 nm. Exosomes contain endogenous proteins and nucleic acids; delivery of these molecules to exosome-recipient cells causes biological effects. Exosomes derived from some types of cells such as mesenchymal stem cells and dendritic cells have therapeutic potential and may be biocompatible and efficient agents against various disorders such as organ injury. However, there are many challenges for the development of exosome-based therapeutics. In particular, producing exosomal formulations is the major barrier for therapeutic application because of their heterogeneity and low productivity. Development and optimization of producing methods, including methods for isolation and storage of exosome formulations, are required for realizing exosome-based therapeutics. In addition, improvement of therapeutic potential and delivery efficiency of exosomes are important for their therapeutic application. In this review, we summarize current knowledge about therapeutic application of exosomes and discuss some challenges in their successful use.
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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
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Cited by
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J.-H. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,122
Therapeutic Nanoparticles and Their Targeted Delivery Applications
Yetisgin, A. A., Cetinel, S., Zuvin, M., Kosar, A., & Kutlu, O. (2020) · Molecules · doi:10.3390/molecules25092193 · Cited by 1,080
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
Kimiz-Gebologlu, I., & Oncel, S. S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 722
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
Biodistribution of extracellular vesicles following administration into animals: A systematic review
Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. W. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 485
Metadata
- Authors
- Yamashita, T., Takahashi, Y., & Takakura, Y.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2018-06-01
- Volume
- 41
- Issue
- 6
- Pages
- 835-842
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2805148808
- Cited by
- 306
- References
- 9
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Yamashita, T., Takahashi, Y., & Takakura, Y. (2018). Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application. Biological and Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.b18-00133
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