An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles
Open accessAbstract
The biomolecular corona promotes a switch of both the cell entry mechanism and the intracellular dynamics of liposomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The targeting capability of PCSN could be partly linked with some serum proteins recruited at the surface of PCSN.
“Considering that apolipoproteins on nanoparticle play an important role in association with cellular uptake to target cells32–34, targeting capability of PCSN partly could be linked with some serum proteins recruited at the surface of PCSN.”
From Cloaking nanoparticles with protein corona shield for targeted drug delivery. (2018) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A guided tour into subcellular colocalization analysis in light microscopy
Bolte, S., & Cordelières, F. (2006) · Journal of Microscopy · doi:10.1111/j.1365-2818.2006.01706.x · Cited by 5,238 · see citing works
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works
Self-citationMaesschalck, R. D., Jouan-Rimbaud, D., & Massart, D. L. (2000) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/s0169-7439(99)00047-7 · Cited by 2,336 · see citing works
Measurement of co‐localization of objects in dual‐colour confocal images
Manders, E. M. M., Verbeek, F. J., & Aten, J. A. (1993) · Journal of Microscopy · doi:10.1111/j.1365-2818.1993.tb03313.x · Cited by 2,132 · see citing works
A practical guide to evaluating colocalization in biological microscopy.
Dunn, K., Kamocka, M., & McDonald, J. (2011) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00462.2010 · Cited by 1,998 · see citing works
Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912 · see citing works
Walkey, C. D., & Chan, W. C. W. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15233e · Cited by 1,758 · see citing works
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000245 · Cited by 1,600 · see citing works
Adler, J., & Parmryd, I. (2010) · Cytometry Part A · doi:10.1002/cyto.a.20896 · Cited by 1,097 · see citing works
Rejman, J., Bragonzi, A., & Conese, M. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.03.038 · Cited by 851 · see citing works
Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles
Walkey, C., Olsen, J. B., Song, F., Liu, R., Guo, H., Olsen, D. W. H., Cohen, Y., Emili, A., & Chan, W. C. W. (2014) · ACS Nano · doi:10.1021/nn406018q · Cited by 824 · see citing works
Swanson, J. A., & Watts, C. K. W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89101-1 · Cited by 735 · see citing works
The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery
Corbo, C., Molinaro, R., Parodi, A., Furman, N. E. T., Salvatore, F., & Tasciotti, E. (2015) · Nanomedicine · doi:10.2217/nnm.15.188 · Cited by 704 · see citing works
The nanoparticle biomolecule corona: lessons learned – challenge accepted?
Docter, D., Westmeier, D., Markiewicz, M., Stolte, S., Knauer, S. K., & Stauber, R. H. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00217f · Cited by 696 · see citing works
Learning a Mahalanobis distance metric for data clustering and classification
Xiang, S., Nie, F., & Zhang, C. (2008) · Pattern Recognition · doi:10.1016/j.patcog.2008.05.018 · Cited by 629 · see citing works
Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
Zhang, X., Xu, X., Bertrand, N., Pridgen, E. M., Swami, A., & Farokhzad, O. C. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.005 · Cited by 494 · see citing works
Effect of nitrogen on band alignment in HfSiON gate dielectrics
Sayan, Ş., Nguyen, N. V., Ehrstein, J. R., Chambers, J. J., Visokay, M. R., Quevedo-Lopez, M. A., Colombo, L., Yoder, D., Levin, I., Fischer, D. A., et al. (2005) · Applied Physics Letters · doi:10.1063/1.2135390 · Cited by 457 · see citing works
Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona
Caracciolo, G., Farokhzad, O. C., & Mahmoudi, M. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.08.011 · Cited by 426 · see citing works
Self-citationHébert, B., Costantino, S., & Wiseman, P. W. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.054874 · Cited by 403 · see citing works
Mapping protein binding sites on the biomolecular corona of nanoparticles
Kelly, P. M., Åberg, C., Polo, E., O'Connell, A., Cookman, J., Fallon, J., Krpetić, Ž., & Dawson, K. A. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.47 · Cited by 360 · see citing works
Time Evolution of Nanoparticle–Protein Corona in Human Plasma: Relevance for Targeted Drug Delivery
Barrán-Berdón, A. L., Pozzi, D., Caracciolo, G., Capriotti, A. L., Caruso, G., Cavaliere, C., Anna Riccioli, A., Palchetti, S., & Laganà, A. (2013) · Langmuir · doi:10.1021/la401192x · Cited by 290 · see citing works
Self-citationCaracciolo, G. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.11.003 · Cited by 246 · see citing works
Self-citationIdentification of Receptor Binding to the Biomolecular Corona of Nanoparticles
Lara, S., Alnasser, F., Polo, E., Garry, D., Giudice, C. L., Hristov, D. R., Rocks, L., Salvati, A. L., Yan, Y., & Dawson, K. A. (2017) · ACS Nano · doi:10.1021/acsnano.6b07933 · Cited by 244 · see citing works
Multiple Internalization Pathways of Polyelectrolyte Multilayer Capsules into Mammalian Cells
Kastl, L., Sasse, D., Wulf, V., Hartmann, R., Mircheski, J., Ranke, C., Carregal‐Romero, S., Martínez‐López, J. A., Fernández‐Chacón, R., Parak, W. J., et al. (2013) · ACS Nano · doi:10.1021/nn306032k · Cited by 189 · see citing works
Bertoli, F., Garry, D., Monopoli, M. P., Salvati, A. L., & Dawson, K. A. (2016) · ACS Nano · doi:10.1021/acsnano.6b06411 · Cited by 189 · see citing works
Rienzo, C. D., Gratton, E., Beltram, F., & Cardarelli, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222097110 · Cited by 176 · see citing works
Self-citationTechniques for the experimental investigation of the protein corona
Carrillo‐Carrión, C., Carril, M., & Parak, W. J. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.02.009 · Cited by 158 · see citing works
Bigdeli, A., Palchetti, S., Pozzi, D., Hormozi-Nezhad, M. R., Baldelli Bombelli, F., Caracciolo, G., & Mahmoudi, M. (2016) · ACS Nano · doi:10.1021/acsnano.6b00261 · Cited by 157 · see citing works
Self-citationGiudice, C. L., Herda, L. M., Polo, E., & Dawson, K. A. (2016) · Nature Communications · doi:10.1038/ncomms13475 · Cited by 156 · see citing works
Prediction of nanoparticles-cell association based on corona proteins and physicochemical properties
Liu, R., Jiang, W., Walkey, C., Chan, W. C. W., & Cohen, Y. (2015) · Nanoscale · doi:10.1039/c5nr01537e · Cited by 147 · see citing works
Protein corona – from molecular adsorption to physiological complexity
Treuel, L., Docter, D., Maskos, M., & Stauber, R. H. (2015) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.6.88 · Cited by 133 · see citing works
Maffre, P., Nienhaus, K., Amin, F., Parak, W. J., & Nienhaus, G. U. (2011) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.2.43 · Cited by 129 · see citing works
The liposome–protein corona in mice and humans and its implications for in vivo delivery
Caracciolo, G., Pozzi, D., Capriotti, A. L., Cavaliere, C., Piovesana, S., Barbera, G. L., Amici, A. R. D., & Laganà, A. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01316f · Cited by 118 · see citing works
Self-citationPolo, E., Collado, M., Pelaz, B., & del Pino, P. (2017) · ACS Nano · doi:10.1021/acsnano.7b01197 · Cited by 118 · see citing works
Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles
Mahmoudi, M., Sheibani, S., Milani, A. S., Rezaee, F., Gauberti, M., Dinarvand, R., & Vali, H. (2015) · Nanomedicine · doi:10.2217/nnm.14.69 · Cited by 112 · see citing works
Self-citationCardarelli, F., Pozzi, D., Bifone, A., Marchini, C., & Caracciolo, G. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200374e · Cited by 104 · see citing works
Self-citationNanomedicine Delivery: does Protein Corona Route to the Target or off Road?
Maiolo, D., del Pino, P., Metrangolo, P., Parak, W. J., & Bombelli, F. B. (2015) · Nanomedicine · doi:10.2217/nnm.15.163 · Cited by 98 · see citing works
Nanoparticles-cell association predicted by protein corona fingerprints
Palchetti, S., Digiacomo, L., Pozzi, D., Peruzzi, G., Micarelli, E., Mahmoudi, M., & Caracciolo, G. (2016) · Nanoscale · doi:10.1039/c6nr03898k · Cited by 92 · see citing works
Self-citationDynamic Colocalization Microscopy To Characterize Intracellular Trafficking of Nanomedicines
Vercauteren, D., Deschout, H. G., Remaut, K., Engbersen, J. F. J., Jones, A. T., Demeester, J., Smedt, S. C. D., & Braeckmans, K. (2011) · ACS Nano · doi:10.1021/nn2020858 · Cited by 90 · see citing works
Nanotechnologies for biomedical science and translational medicine
Heath, J. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515202112 · Cited by 89 · see citing works
A high-density lipoprotein-mediated drug delivery system
Mo, Z., Ren, K., Liu, X., Tang, Z., & Yi, G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.030 · Cited by 75 · see citing works
Hristov, D. R., Rocks, L., Kelly, P. M., Thomas, S. S., Pitek, A. S., Verderio, P., Mahon, E., & Dawson, K. A. (2015) · Scientific Reports · doi:10.1038/srep17040 · Cited by 67 · see citing works
Multicomponent Cationic Lipid−DNA Complex Formation: Role of Lipid Mixing
Caracciolo, G., Pozzi, D., Amenitsch, H. W., & Caminiti, R. (2005) · Langmuir · doi:10.1021/la052077c · Cited by 65 · see citing works
Self-citationSahneh, F. D., Scoglio, C., Monteiro-Riviere, N. A., & Riviere, J. E. (2014) · Nanomedicine · doi:10.2217/nnm.14.60 · Cited by 60 · see citing works
O’Connell, D. J., Bombelli, F. B., Pitek, A. S., Monopoli, M. P., Cahill, D. J., & Dawson, K. A. (2015) · Nanoscale · doi:10.1039/c5nr01970b · Cited by 58 · see citing works
Pozzi, D., Marchini, C., Cardarelli, F., Rossetta, A., Colapicchioni, V., Amici, A. R. D., Montani, M., Motta, S., Brocca, P., Cantú, L., et al. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400470p · Cited by 56 · see citing works
Self-citationThe effect of the protein corona on the interaction between nanoparticles and lipid bilayers
Silvio, D. D., Maccarini, M., Parker, R., Mackie, A. R., Fragneto, G., & Bombelli, F. B. (2017) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2017.05.086 · Cited by 52 · see citing works
Ojeda, E., Puras, G., Agirre, M., Sesma, J. Z., Grijalvo, S., Eritja, R., Digiacomo, L., Caracciolo, G., & Pedraz, J. L. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.02.043 · Cited by 38 · see citing works
Self-citationCaracciolo, G., Pozzi, D., Caminiti, R., & Amenitsch, H. W. (2005) · Applied Physics Letters · doi:10.1063/1.2058202 · Cited by 36 · see citing works
Self-citationPalchetti, S., Pozzi, D., Marchini, C., Amici, A. R. D., Andreani, C., Bartolacci, C., Digiacomo, L., Gambini, V., Cardarelli, F., Rienzo, C. D., et al. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.08.019 · Cited by 32 · see citing works
Self-citationDigiacomo, L., Digman, M. A., Gratton, E., & Caracciolo, G. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.031 · Cited by 26 · see citing works
Self-citationSpatial and Structural Metrics for Living Cells Inspired by Statistical Mechanics
Åberg, C., Varela, J. A., Fitzpatrick, L. W., & Dawson, K. A. (2016) · Scientific Reports · doi:10.1038/srep34457 · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 49
- [1]Caracciolo G Nanomedicine: Nanotechnology, Biology and Medicine 2015 11 543 557 25555353
- [2]Docter D Westmeier D Markiewicz M Stolte S Knauer S Stauber R Chemical Society reviews 2015 44 6094 6121 26065524
- [3]Mahmoudi M Sheibani S Milani AS Rezaee F Gauberti M Dinarvand R Vali H Nanomedicine 2015 10 215 226 25600967
- [4]Maiolo D Del Pino P Metrangolo P Parak WJ Baldelli Bombelli F Nanomedicine 2015 10 3231 3247 26470748
- [5]Corbo C Molinaro R Parodi A Toledano Furman NE Salvatore F Tasciotti E Nanomedicine 2016 11 81 100 26653875 PMC4910943
- [6]Caracciolo G Farokhzad OC Mahmoudi M Trends in Biotechnology 2017 35 257 264 27663778
- [7]Polo E Collado M Pelaz B del Pino P ACS nano 2017 11 2397 2402 28267316
- [8]Salvati A Pitek AS Monopoli MP Prapainop K Bombelli FB Hristov DR Kelly PM Åberg C Mahon E Dawson KA Nature nanotechnology 2013 8 137 143 23334168
- [9]Walkey CD Chan WCW Chemical Society Reviews 2012 41 2780 2799 22086677
- [10]Behzadi S Serpooshan V Tao W Hamaly MA Alkawareek MY Dreaden EC Brown D Alkilany AM Farokhzad OC Mahmoudi M Chemical Society Reviews 2017 PMC5593313 28585944
- [11]Di Silvio D Maccarini M Parker R Mackie A Fragneto G Bombelli FB Journal of Colloid and Interface Science 2017 28623699
- [12]Carrillo-Carrion C Carril M Parak WJ Current Opinion in Biotechnology 2017 46 106 113 28301820
- [13]Walkey CD Olsen JB Song F Liu R Guo H Olsen DWH Cohen Y Emili A Chan WC ACS nano 2014 8 2439 2455 24517450
- [14]Liu R Jiang W Walkey CD Chan WC Cohen Y Nanoscale 2015 7 9664 9675 25959034
- [15]Sahneh FD Scoglio CM Monteiro-Riviere NA Riviere JE Nanomedicine 2015 10 25 33 25032980
- [16]Treuel L Docter D Maskos M Stauber RH Beilstein journal of nanotechnology 2015 6 857 873 25977856 PMC4419682
- [17]Pozzi D Marchini C Cardarelli F Rossetta A Colapicchioni V Amici A Montani M Motta S Brocca P Cantù L Molecular pharmaceutics 2013 10 4654 4665 24188138
- [18]Ojeda E Puras G Agirre M Zarate J Grijalvo S Eritja R Digiacomo L Caracciolo G Pedraz JL International Journal of Pharmaceutics 2016 503 115 126 26956159
- [19]Rejman J Bragonzi A Conese M Molecular Therapy 2005 12 468 474 15963763
- [20]Swanson JA Watts C Trends in cell biology 1995 5 424 428 14732047
- [21]Caracciolo G Pozzi D Amenitsch H Caminiti R Langmuir 2005 21 11582 11587 16316084
- [22]Caracciolo G Pozzi D Caminiti R Amenitsch H Applied Physics Letters 2005 87 1 3
- [23]Palchetti S Pozzi D Marchini C Amici A Andreani C Bartolacci C Digiacomo L Gambini V Cardarelli F Di Rienzo C Peruzzi G Amenitsch H Palermo R Screpanti I Caracciolo G Nanomedicine: Nanotechnology, Biology, and Medicine 2017 13 681 691 27565691
- [24]Kastl L Sasse D Wulf V Hartmann R Mircheski J Ranke C Carregal-Romero S Martínez-López JA Fernández-Chacón R Parak WJ Elsasser H-P Rivera_Gil P ACS Nano 2013 7 6605 6618 23826767
- [25]Vercauteren D Deschout H Remaut K Engbersen JFJ Jones AT Demeester J De Smedt SC Braeckmans K ACS Nano 2011 5 7874 7884 21923168
- [26]Cardarelli F Pozzi D Bifone A Marchini C Caracciolo G Molecular Pharmaceutics 2012 9 334 340 22196199
- [27]Digiacomo L Digman MA Gratton E Caracciolo G Acta Biomaterialia 2016 42 189 198 27449340 PMC5483853
- [28]Åberg C Varela JA Fitzpatrick LW Dawson KA Scientific reports 2016 6 PMC5052623 27708351
- [29]Heath JR Proceedings of the National Academy of Sciences 2015 112 14436 14443 PMC4664315 26598663
- [30]Bigdeli A Palchetti S Pozzi D Hormozi-Nezhad MR Bombelli FBaldelli Caracciolo G Mahmoudi M ACS nano 2016 10 3723 3737 26882007
- [31]Palchetti S Digiacomo L Pozzi D Peruzzi G Micarelli E Mahmoudi M Caracciolo G Nanoscale 2016 8 12755 12763 27279572
- [32]Caracciolo G Pozzi D Capriotti AL Cavaliere C Piovesana S La Barbera G Amici A Laganà A Journal of Materials Chemistry B 2014 2 7419 7428 32261967
- [33]Adler J Parmryd I Cytometry Part A 2010 77 733 742 20653013
- [36]Goldstein JL Brown MS Anderson RG Russell DW Schneider WJ Annual review of cell biology 1985 1 1 39 2881559
- [37]Maffre P Nienhaus K Amin F Parak WJ Nienhaus GU Beilstein Journal of Nanotechnology 2011 2 374 383 22003445 PMC3190609
- [38]Lara S Alnasser F Polo E Garry D Lo Giudice MC Hristov DR Rocks L Salvati A Yan Y Dawson KA ACS nano 2017 11 1884 1893 28112950
- [39]Kelly PM Åberg C Polo E O’Connell A Cookman J Fallon J Krpetić Ž Dawson KA Nature nanotechnology 2015 10 472 479 25822932
- [40]O’Connell D Bombelli FB Pitek A Monopoli M Cahill D Dawson K Nanoscale 2015 7 15268 15276 26324751
- [41]Giudice MCL Herda LM Polo E Dawson KA Nature Communications 2016 7 13475 PMC5116075 27845346
- [42]Hristov DR Rocks L Kelly PM Thomas SS Pitek AS Verderio P Mahon E Dawson KA Scientific reports 2015 5 17040 26621190 PMC4664868
- [43]Bertoli F Garry D Monopoli MP Salvati A Dawson KA ACS nano 2016 10 10471 10479 27797479
- [44]Zhang XQ Xu X Bertrand N Pridgen E Swami A Farokhzad OC Advanced drug delivery reviews 2012 64 1363 1384 22917779 PMC3517211
- [45]Mo ZC Ren K Liu X Tang ZL Yi GH Advanced drug delivery reviews 2016 106 132 147 27208399
- [46]Manders E Verbeek F Aten J Journal of microscopy 1993 169 375 382 33930978
- [47]Bolte S Cordelieres F Journal of microscopy 2006 224 213 232 17210054
- [48]Dunn KW Kamocka MM McDonald JH American Journal of Physiology-Cell Physiology 2011 300 C723 C742 21209361 PMC3074624
- [49]Di Rienzo C Gratton E Beltram F Cardarelli F Proceedings of the National Academy of Sciences 2013 110 12307 12312 PMC3725058 23836651
- [50]Hebert B Costantino S Wiseman PW Biophysical journal 2005 88 3601 3614 15722439 PMC1305507
- [51]Barrán-Berdón AL Pozzi D Caracciolo G Capriotti AL Caruso G Cavaliere C Riccioli A Palchetti S Laganaì A Langmuir 2013 29 6485 6494 23631648
Cited by
Sorted by citations
The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine
Cai, R., & Chen, C. (2018) · Advanced Materials · doi:10.1002/adma.201805740 · Cited by 599 · see citing works
Cloaking nanoparticles with protein corona shield for targeted drug delivery.
Oh, J. Y., Kim, H. S., Palanikumar, L., Go, E. M., Jana, B., Park, S. A., Kim, H. Y., Kim, K., Seo, J. K., Kwak, S. K., et al. (2018) · Nature communications · doi:10.1038/s41467-018-06979-4 · Cited by 409 · see citing works
Yamashita, T., Takahashi, Y., & Takakura, Y. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00133 · Cited by 308 · see citing works
Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles
Francia, V., Yang, K., Deville, S., Reker‐Smit, C., Nelissen, I., & Salvati, A. L. (2019) · ACS Nano · doi:10.1021/acsnano.9b03824 · Cited by 306 · see citing works
Gandek, T. B., van der Koog, L., & Nagelkerke, A. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300319 · Cited by 242 · see citing works
Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy
Liu, C., Zhang, L., Zhu, W., Guo, R., Sun, H., Chen, X., & Deng, N. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.07.015 · Cited by 239 · see citing works
The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells
Liu, N., Tang, M. X., & Ding, J. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125624 · Cited by 170 · see citing works
Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2019) · Nanoscale · doi:10.1039/c8nr09855g · Cited by 153 · see citing works
Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments
Pinals, R. L., Yang, D., Rosenberg, D. J., Chaudhary, T., Crothers, A. R., Iavarone, A. T., Hammel, M., & Landry, M. P. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202008175 · Cited by 153 · see citing works
Francia, V., Montizaan, D., & Salvati, A. L. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.25 · Cited by 137 · see citing works
Chen, D., Parayath, N. N., Ganesh, S., Wang, W., & Amiji, M. M. (2019) · Nanoscale · doi:10.1039/c9nr05788a · Cited by 135 · see citing works
Graphene oxide touches blood: in vivo interactions of bio-coronated 2D materials
Palmieri, V., Perini, G., Spirito, M. D., & Papi, M. (2018) · Nanoscale Horizons · doi:10.1039/c8nh00318a · Cited by 133 · see citing works
Sayers, E. J., Peel, S. E., Schantz, A., England, R., Beano, M., Bates, S. M., Desai, A. S., Puri, S., Ashford, M. B., & Jones, A. T. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.07.018 · Cited by 117 · see citing works
Cancer‐Targeted Nanomedicine: Overcoming the Barrier of the Protein Corona
Barui, A. K., Oh, J. Y., Jana, B., Kim, C., & Ryu, J. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201900124 · Cited by 116 · see citing works
Uptake of extracellular vesicles into immune cells is enhanced by the protein corona
Dietz, L., Oberländer, J., Mateos‐Maroto, A., Schunke, J., Fichter, M., Krämer‐Albers, E., Landfester, K., & Mailänder, V. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12399 · Cited by 116 · see citing works
Coty, J.-B., & Vauthier, C. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.013 · Cited by 114 · see citing works
Clinically approved liposomal nanomedicines: lessons learned from the biomolecular corona
Caracciolo, G. (2018) · Nanoscale · doi:10.1039/c7nr07450f · Cited by 106 · see citing works
Self-citationA health concern regarding the protein corona, aggregation and disaggregation
Falahati, M., Attar, F., Sharifi, M., Haertlé, T., Berret, J., Khan, R. H., & Saboury, A. A. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.02.012 · Cited by 105 · see citing works
Formation of a protein corona influences the biological identity of nanomaterials
Nierenberg, D., Khaled, A. R., & Flores, O. (2018) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2018.05.005 · Cited by 102 · see citing works
Impact of the protein corona on nanomaterial immune response and targeting ability
Digiacomo, L., Pozzi, D., Palchetti, S., Zingoni, A., & Caracciolo, G. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1615 · Cited by 96 · see citing works
Self-citationSu, G., Jiang, H., Xu, B., Yu, Y., & Chen, X. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00612 · Cited by 92 · see citing works
Tuning liposome composition to modulate corona formation in human serum and cellular uptake
Yang, K., Mesquita, B. S., Horvatovich, P. L., & Salvati, A. L. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.02.018 · Cited by 83 · see citing works
Spotlight on the protein corona of liposomes
Onishchenko, N. R., Tretiakova, D. S., & Vodovozova, E. L. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.07.074 · Cited by 81 · see citing works
Disease-related metabolites affect protein–nanoparticle interactions
Tavakol, M., Montazeri, A., Naghdabadi, R., Hajipour, M. J., Zanganeh, S., Caracciolo, G., & Mahmoudi, M. (2018) · Nanoscale · doi:10.1039/c7nr09502c · Cited by 79 · see citing works
Self-citationArcella, A., Palchetti, S., Digiacomo, L., Pozzi, D., Capriotti, A. L., Frati, L., Oliva, M. A., Tsaouli, G., Rota, R., Screpanti, I., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00339 · Cited by 77 · see citing works
Self-citationLooking Back, Moving Forward: Lipid Nanoparticles as a Promising Frontier in Gene Delivery
Pozzi, D., & Caracciolo, G. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00185 · Cited by 74 · see citing works
Self-citationOpsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties In Vivo
Giulimondi, F., Vulpis, E., Digiacomo, L., Giuli, M. V., Mancusi, A., Capriotti, A. L., Laganà, A., Cerrato, A., Chiozzi, R. Z., Nicoletti, C., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c07687 · Cited by 72 · see citing works
Self-citationFrancia, V., Reker‐Smit, C., Boel, G., & Salvati, A. L. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0446 · Cited by 71 · see citing works
Caracciolo, G., Palchetti, S., Digiacomo, L., Chiozzi, R. Z., Capriotti, A. L., Amenitsch, H. W., Tentori, P. M., Palmieri, V., Papi, M., Cardarelli, F., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04962 · Cited by 70 · see citing works
Self-citationKari, O. K., Ndika, J., Parkkila, P., Louna, A., Lajunen, T., Puustinen, A., Viitala, T., Alenius, H. T., & Urtti, A. O. (2019) · Nanoscale · doi:10.1039/c9nr08186k · Cited by 69 · see citing works
Protein corona, influence on drug delivery system and its improvement strategy: A review
Guo, F., Luo, S., Wang, L., Wang, M., Wu, F., Wang, Y., Jiao, Y., Du, Y., Yang, Q., Yang, X., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128513 · Cited by 58 · see citing works
Biomolecular Corona Affects Controlled Release of Drug Payloads from Nanocarriers
Sharifi, S., Caracciolo, G., & Mahmoudi, M. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.06.011 · Cited by 54 · see citing works
Self-citationIn Planta Nanosensors: Understanding Biocorona Formation for Functional Design
Voke, E., Pinals, R. L., Goh, N. S., & Landry, M. P. (2021) · ACS Sensors · doi:10.1021/acssensors.1c01159 · Cited by 54 · see citing works
Pay Attention to Biological Nanoparticles when Studying the Protein Corona on Nanomedicines
Simonsen, J. B., & Münter, R. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202004611 · Cited by 52 · see citing works
Tuning the immune system by nanoparticle–biomolecular corona
Palmieri, V., & Caracciolo, G. (2022) · Nanoscale Advances · doi:10.1039/d2na00290f · Cited by 50 · see citing works
Self-citationOn the mechanism of tissue-selective gene delivery by lipid nanoparticles
Kimura, S., & Harashima, H. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.052 · Cited by 46 · see citing works
Hammond, J., Richards, C. J., Ko, Y., Jonker, T., Åberg, C., Roos, W. H., & Lira, R. B. (2025) · Small · doi:10.1002/smll.202408039 · Cited by 46 · see citing works
Surface Chemistry of Biologically Active Reducible Oxide Nanozymes
Neal, C. J., Kolanthai, E., Wei, F., Coathup, M. J., & Seal, S. (2023) · Advanced Materials · doi:10.1002/adma.202211261 · Cited by 43 · see citing works
Engineered and Mimicked Extracellular Nanovesicles for Therapeutic Delivery
Poinsot, V., Pizzinat, N., & Ong‐Meang, V. (2024) · Nanomaterials · doi:10.3390/nano14070639 · Cited by 38 · see citing works
Interplay between nanomedicine and protein corona
Yang, M., Wu, E., Tang, W., Qian, J., & Zhan, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01063h · Cited by 38 · see citing works
Liposome protein corona characterization as a new approach in nanomedicine
Capriotti, A. L., Cavaliere, C., & Piovesana, S. (2019) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-019-01656-x · Cited by 37 · see citing works
Self-citationBiohybrid Nanoparticles to Negotiate with Biological Barriers
Mohammadi, M. R., Corbo, C., Molinaro, R., & Lakey, J. R. T. (2019) · Small · doi:10.1002/smll.201902333 · Cited by 37 · see citing works
Engineering surface patterns on nanoparticles: new insights into nano-bio interactions
Hu, B., Liu, R., Liu, Q., Lin, Z., Shi, Y., Li, J., Wang, L., Li, L., Xiao, X., & Wu, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02549j · Cited by 36 · see citing works
Systematic modulation of the lipid composition enables the tuning of liposome cellular uptake
Mateos‐Maroto, A., Gai, M., Brückner, M., Marques, R. D. C., Harley, I., Simon, J., Mailänder, V., Morsbach, S., & Landfester, K. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.058 · Cited by 35 · see citing works
A decade of the liposome-protein corona: Lessons learned and future breakthroughs in theranostics
Quagliarini, E., Digiacomo, L., Renzi, S., Pozzi, D., & Caracciolo, G. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101657 · Cited by 35 · see citing works
Self-citationSystematic and mechanistic analysis of AuNP-induced nanotoxicity for risk assessment of nanomedicine
Lee, E., Lee, M., Kwon, S., Kim, J., & Kwon, Y. (2022) · Nano Convergence · doi:10.1186/s40580-022-00320-y · Cited by 34 · see citing works
Artificial protein coronas: directing nanoparticles to targets
Caracciolo, G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.05.003 · Cited by 31 · see citing works
Self-citationImmunoglobulins on the surface of differently charged polymer nanoparticles
Prozeller, D., Rosenauer, C., Morsbach, S., & Landfester, K. (2020) · Biointerphases · doi:10.1116/6.0000139 · Cited by 31 · see citing works
Srivastava, I., Khan, M. S., Dighe, K., Alafeef, M., Wang, Z., Banerjee, T., Ghonge, T., Grove, L. M., Bashir, R., & Pan, D. (2020) · Small Methods · doi:10.1002/smtd.202000099 · Cited by 28 · see citing works
Liu, L., Xu, Y., Ma, Y., Duan, F., Wang, C., Feng, J., Yin, H., Sun, L., Li, P., & Li, Z. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137596 · Cited by 27 · see citing works
Theranostic Lipid Nanoparticles for Renal Cell Carcinoma
Mao, X., Wang, G., Wang, Z., Duan, C., Wu, X., & Xu, H. (2023) · Advanced Materials · doi:10.1002/adma.202306246 · Cited by 27 · see citing works
Gerasimovich, E. S., Karaulov, A. V., Nabiev, I. R., & Sukhanova, A. V. (2025) · Nanomaterials · doi:10.3390/nano15131013 · Cited by 26 · see citing works
Optimal centrifugal isolating of liposome–protein complexes from human plasma
Digiacomo, L., Giulimondi, F., Capriotti, A. L., Piovesana, S., Montone, C. M., Chiozzi, R. Z., Laganà, A., Mahmoudi, M., Pozzi, D., & Caracciolo, G. (2021) · Nanoscale Advances · doi:10.1039/d1na00211b · Cited by 24 · see citing works
Self-citationCharge-switchable cell-penetrating peptides for rerouting nanoparticles to glioblastoma treatment
Mendes, M., Nunes, S. C. C., Cova, T. F. G. G., Branco, F., Dyrks, M., Koksch, B., Vale, N., Sousa, J., Pais, A. A. C. C., & Vitorino, C. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113983 · Cited by 24 · see citing works
Digiacomo, L., Giulimondi, F., Mahmoudi, M., & Caracciolo, G. (2019) · Nanoscale Advances · doi:10.1039/c9na00195f · Cited by 24 · see citing works
Self-citationThe Relation Between Protein Adsorption and Hemocompatibility of Antifouling Polymer Brushes
Riedelová, Z., Pereira, A. D. L. S., Svoboda, J., Pop‐Georgievski, O., Májek, P., Pečánková, K., Dyčka, F., Rodriguez‐Emmenegger, C., & Riedel, T. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202200247 · Cited by 23 · see citing works
A mechanistic explanation of the inhibitory role of the protein corona on liposomal gene expression
Palchetti, S., Digiacomo, L., Giulimondi, F., Pozzi, D., Peruzzi, G., Ferri, G., Amenitsch, H. W., Cardarelli, F., Mahmoudi, M., & Caracciolo, G. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.183159 · Cited by 21 · see citing works
Self-citationTargeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy
Marschall, A. L. J. (2021) · BioDrugs · doi:10.1007/s40259-021-00500-y · Cited by 21 · see citing works
Protein adsorption onto nanomaterials engineered for theranostic applications
Nienhaus, K., Xue, Y., Shang, L., & Nienhaus, G. U. (2022) · Nanotechnology · doi:10.1088/1361-6528/ac5e6c · Cited by 20 · see citing works
Quagliarini, E., Santo, R. D., Palchetti, S., Ferri, G., Cardarelli, F., Pozzi, D., & Caracciolo, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020113 · Cited by 19 · see citing works
Self-citationDigiacomo, L., Giulimondi, F., Pozzi, D., Coppola, A., Vaccara, V. L., Caputo, D. D., & Caracciolo, G. (2021) · Journal of Nanotheranostics · doi:10.3390/jnt2020006 · Cited by 19 · see citing works
Self-citationJang, G. J., Jeong, J. Y., Kang, J., Cho, W., & Han, S. Y. (2021) · Langmuir · doi:10.1021/acs.langmuir.1c01182 · Cited by 18 · see citing works
The influence of protein corona on liposomal delivery systems: A comprehensive review
Mojarad-Jabali, S., Fatahi, Y., & Dinarvand, R. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107166 · Cited by 17 · see citing works
Tretiakova, D. S., Kobanenko, M. K., Alekseeva, A. S., Boldyrev, I. A., Khaidukov, S. V., Zgoda, V. G., Tikhonova, O. V., Vodovozova, E. L., & Onishchenko, N. R. (2023) · Membranes · doi:10.3390/membranes13070681 · Cited by 17 · see citing works
Shaw, J. R., & Pearson, R. M. (2022) · Biomaterials Science · doi:10.1039/d2bm00315e · Cited by 16 · see citing works
Looking back, moving forward: protein corona of lipid nanoparticles
Gao, Y., Huang, Y., Ren, C., Chou, P., Wu, C., Pan, X., Quan, G., & Huang, Z. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00186a · Cited by 15 · see citing works
Isobaric Labeling Proteomics Allows a High-Throughput Investigation of Protein Corona Orientation
Liessi, N., Maragliano, L., Castagnola, V., Bramini, M., Benfenati, F., & Armirotti, A. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03134 · Cited by 15 · see citing works
Saini, A., Li, S., Wang, Z., Plebanski, M., & Ju, Y. (2026) · ACS Nano · doi:10.1021/acsnano.6c00334 · Cited by 14 · see citing works
Martin, K. E., Kalelkar, P. P., Coronel, M. M., Theriault, H. S., Schneider, R. S., & Garcı́a, A. J. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121601 · Cited by 14 · see citing works
Giulimondi, F., Digiacomo, L., Renzi, S., Cassone, C., Pirrottina, A., Molfetta, R., Palamà, I. E., Maiorano, G., Gigli, G., Amenitsch, H. W., et al. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00103 · Cited by 14 · see citing works
Self-citationThe effect of biomolecular corona on adsorption onto and desorption from a model lipid membrane
Richards, C. J., Ahmadi, M., Stuart, M. C. A., Kooi, B. J., Åberg, C., & Roos, W. H. (2022) · Nanoscale · doi:10.1039/d2nr05296b · Cited by 13 · see citing works
Muenzebrock, K. A., Ho, F. Y. W., Pontes, A. P., Jorquera‐Cordero, C., Utomo, L., Garcia, J. P., Willems, P. C. P. H., Welting, T. J. M., Rip, J., & Creemers, L. B. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040438 · Cited by 13 · see citing works
Ojansivu, M., Barriga, H. M. G., Holme, M. N., Morf, S., Doutch, J., Andaloussi, S. E., Kjellman, T., Johnsson, M., Barauskas, J., & Stevens, M. M. (2025) · Advanced Materials · doi:10.1002/adma.202419538 · Cited by 12 · see citing works
Palchetti, S., Digiacomo, L., Pozzi, D., Chiozzi, R. Z., Capriotti, A. L., Laganà, A., Coppola, R., Caputo, D. D., Sharifzadeh, M. S., Mahmoudi, M., et al. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800221 · Cited by 12 · see citing works
Self-citationSorafenib—Drug Delivery Strategies in Primary Liver Cancer
Szyk, P., Czarczyńska-Goślińska, B., Ziegler-Borowska, M., Larrosa, I., & Gośliński, T. A. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16040148 · Cited by 11 · see citing works
Zhang, M., Van, L. M., & Amiji, M. M. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102686 · Cited by 11 · see citing works
Battaglini, M., Gümüş, M. B., & Ciofani, G. (2021) · Advanced Materials Technologies · doi:10.1002/admt.202100660 · Cited by 11 · see citing works
Münter, R., & Simonsen, J. B. (2022) · Nanoscale Advances · doi:10.1039/d2na00343k · Cited by 11 · see citing works
Kim, S. H., Lee, C., Jang, G. J., Yoo, S., Lee, S., & Han, S. Y. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c03752 · Cited by 10 · see citing works
Liu, R., Yu, D., El‐Aty, A. M. A., & Tan, M. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104179 · Cited by 10 · see citing works
Advances in siRNA-loaded liposomes for lung cancer: Challenges and future perspectives
Abla, K. K., Zahwi, M. K., El-Lakany, S. A., & Karam, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145461 · Cited by 9 · see citing works
Pay Attention to Biological Nanoparticles when Studying the Protein Corona on Nanomedicines
Simonsen, J. B., & Münter, R. (2020) · Angewandte Chemie · doi:10.1002/ange.202004611 · Cited by 9 · see citing works
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
Giambelluca, M. S., Markova, E., Louet, C., Steinkjer, B., Sundset, R., Škalko‐Basnet, N., & Hak, S. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102712 · Cited by 9 · see citing works
Enhancing Intracellular Uptake of Ivermectin through Liposomal Encapsulation
Kocas, M., Yamashita, F., Çomoğlu, T., & Zhang, Q. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03113-8 · Cited by 7 · see citing works
Kimura, S., & Harashima, H. (2024) · BioDrugs · doi:10.1007/s40259-024-00647-4 · Cited by 7 · see citing works
Cellular uptake of CPX-351 by scavenger receptor class B type 1–mediated nonendocytic pathway
Araie, H., Hosono, N., & Yamauchi, T. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104651 · Cited by 4 · see citing works
Bridging nanocellulose and biological responses through protein corona complexes
Fan, Z., Sawant, T. R., Liu, Z. H., Xu, P., Zhong, C., Zhong, Y., Guo, J., Yu, F., Wang, Q., Liu, H., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153284 · Cited by 3 · see citing works
Assessing the Adverse Effects of Two-Dimensional Materials Using Cell Culture-Based Models
Franqui, L. S., de Luna, L. A. V., Loret, T., Martinez, D. S. T., & Bussy, C. (2019) · Springer eBooks · doi:10.1007/978-3-662-59600-5_1 · Cited by 3 · see citing works
Zhou, S., Deng, C., Xu, P., Fan, Q. W., Zhang, X., Jia, Y., Li, S., He, Q., Liu, Y., & Song, B. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00791 · Cited by 3 · see citing works
Brossa, A., Arena, M., Ceccotti, E., Gregorio, E. D., Ferrauto, G., Bussolati, B., & Bruno, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135795 · Cited by 2 · see citing works
Non-targeted lipidomics reveals the distinct metabolic mechanisms of n ZnO and Zn ions in fish liver
Ma, S., & Wang, W. (2025) · Environmental Science Nano · doi:10.1039/d5en00160a · Cited by 1 · see citing works
Brain delivery of lipid nanoparticles with shuttle peptides
Martínez-Martínez, N., CARRERA-RODRÍGUEZ, L., Vargas, R., Hernández-Munaín, C., Suñé-Pou, M., & Suñé, C. M. I. (2026) · Advances in pharmacology · doi:10.1016/bs.apha.2026.02.005 · Cited by 1 · see citing works
Zhao, F., Ma, X., Kirby-Smith, C., Wolters, J. C., Bartucci, R., & Salvati, A. L. (2026) · ACS Nano · doi:10.1021/acsnano.6c00799 · Cited by 1 · see citing works
Decoding the uptake pathway of nanoparticles in tumor cells: mechanisms, developments and challenges
Chen, Z., Zhou, L., Li, S., & Zhang, X. (2026) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2026.104054 · Cited by 1 · see citing works
Nosova, A. S., Буданова, У. А., & Sebyakin, Y. L. (2019) · Fine Chemical Technologies · doi:10.32362/2410-6593-2019-14-5-7-20 · Cited by 1 · see citing works
Wei, X., Yu, A.-G., Liu, Z.-B., Pantopoulos, K., Xu, P., Zheng, H., & Luo, Z. (2025) · Environmental Science Nano · doi:10.1039/d5en00270b
Generalizable, high-throughput image analysis of subcellular structures using dispersion indices
Martin, A., Zhang, S., Williamson, A. K., Tingley, B. M., Pickus, M., Zurakowski, D., Nia, H. T., Shirihai, O. S., Han, X., & Grinstaff, M. W. (2026) · iScience · doi:10.1016/j.isci.2026.115371
- Authors
- Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M., & Caracciolo, G.
- Affiliations
- Università di Camerino (IT)
- Scuola Normale Superiore (IT)
- Sapienza University of Rome (IT)
- University of California, Irvine (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Mahmoudi, M.
- Caracciolo, G.
- ORCID
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 9
- Issue
- 44
- Pages
- 17254-17262
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- PMC
- PMC5700750
- OpenAlex
- W2766823924
- Cited by
- 109
- References
- 52
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 12
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Scuola Normale Superiore di Pisa (submittedVersion, other-oa)
- Funders
- National Institutes of Health (NIH P50, NIH‐P50 GM076516, GM-076516, NIH P41-GM103540, GM103540)
- National Institute of General Medical Sciences (P41GM103540, P50GM076516)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- biomolecular corona, apolipoproteins, lipid nanoparticles, cellular uptake, macropinocytosis, clathrin-mediated endocytosis, intracellular trafficking, LDL receptor, HeLa cells, plasma exposure, targeted delivery
- MeSH terms
- Protein Corona, Apolipoproteins, Endocytosis, HeLa Cells, Humans, Lipids, Pinocytosis, Tissue Distribution, Drug Delivery Systems, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review