Cited by 111Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryLipid Membrane Structure and Behavior

An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles

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Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M. +1 more·2017·Nanoscale

Abstract

The biomolecular corona promotes a switch of both the cell entry mechanism and the intracellular dynamics of liposomes.

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Crossref · 10.1039/c7nr06437c

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  • The targeting capability of PCSN could be partly linked with some serum proteins recruited at the surface of PCSN.

    “Considering that apolipoproteins on nanoparticle play an important role in association with cellular uptake to target cells32–34, targeting capability of PCSN partly could be linked with some serum proteins recruited at the surface of PCSN.”

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Authors
Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M., & Caracciolo, G.
Affiliations
  • Università di Camerino (IT)
  • Scuola Normale Superiore (IT)
  • Sapienza University of Rome (IT)
  • University of California, Irvine (US)
  • Brigham and Women's Hospital (US)
Corresponding author
  • Mahmoudi, M.
  • Caracciolo, G.
Venue
Nanoscale
Published
2017
Volume
9
Issue
44
Pages
17254-17262
ISSN
  • 2040-3364 (ISSN-L)
  • 2040-3372
OpenAlex
W2766823924
Cited by
109
References
52
Citations by year
2026: 15 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 18 · 2018: 12
FWCI
4.24
Type
journal article
Language
en
Open access
Locations
  • Nanoscale (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Scuola Normale Superiore di Pisa (submittedVersion, other-oa)
Funders
  • National Institutes of Health (NIH P50, NIH‐P50 GM076516, GM-076516, NIH P41-GM103540, GM103540)
  • National Institute of General Medical Sciences (P41GM103540, P50GM076516)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
biomolecular corona, apolipoproteins, lipid nanoparticles, cellular uptake, macropinocytosis, clathrin-mediated endocytosis, intracellular trafficking, LDL receptor, HeLa cells, plasma exposure, targeted delivery
MeSH terms
Protein Corona, Apolipoproteins, Endocytosis, HeLa Cells, Humans, Lipids, Pinocytosis, Tissue Distribution, Drug Delivery Systems, Nanoparticles

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