Effect of theanine on norepinephrine and serotonin levels in rat brain
Open accessAbstract
The effects of i.p. administered theanine (L-N-ethylglutamine), a constituent of Japanese green tea, on the levels of norepinephrine (NE) and serotonin (5-HT) in the brain of rats with or without coadministration of caffeine were investigated, and compared with those of glutamine.Theanine decreased the NE level, whereas no change was observed with glutamine or caffeine.The decrease of NE induced by theanine was reversed by caffeine. In rats pretreated with pargline, a monoamine oxidase inhibitor, theanine significantly increased the NE level compared with the control. However, it did not enhance the NE levels increased by caffeine. Thus, theanine may decrease the NE levels by releasing this neurotransmitter.Theanine did not alter the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in rats pretreated with or without pargyline, indicating that this amide affects neither 5-HT synthesis nor its degradation. Caffeine increased the levels of 5-HT and 5-HIAA in normal rats to similar extents.This effect was depressed by theanine. In rats pretreated with pargyline, the levels of 5-HT and 5-HIAA were not altered by caffeine, and theanine did not modify the outcome. It may be concluded that the action of theanine is related to the possible inhibition of 5-HT release by caffeine. The effect of glutamine on the levels of 5-HT was somewhat different form that of theanine.
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Modulation of the monoamine and glutamic acid and glycine systems may also contribute to the four weeks psychotropic effects of L-theanine.
“The modulation of the monoamine [14,15,16,17] and glutamic acid and glycine [18,19] systems may also contribute to these four weeks psychotropic effects.”
From Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial (2019) · cites this paper as [17]
The Results (p. 2) show that theanine changed norepinephrine levels in rat brain, supporting the monoamine-modulation part attributed to this source. The study measured acute neurochemical effects, not whether monoamine modulation contributes to psychotropic effects over four weeks. The glutamic-acid and glycine portion is assigned to other citations in the citing sentence. (LLM, conf=0.84)
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- Authors
- KIMURA, R., & MURATA, T.
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1986
- Volume
- 34
- Issue
- 7
- Pages
- 3053-3057
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W1974559875
- Cited by
- 51
- References
- 2
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- theanine, norepinephrine, serotonin, 5-hydroxyindoleacetic acid, caffeine, glutamine, pargyline, monoamine oxidase inhibition, neurotransmitter release, brain monoamines
- MeSH terms
- Animals, Brain Chemistry, Glutamates, Male, Norepinephrine, Rats, Inbred Strains, Serotonin, Rats
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