Antiinflammatory Effects of Tetramethylpyrazine and Ferulic Acid.
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Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligusticum wallichii Franch (L. wallichii). Ferulic acid (FA) is a phenolic compound contained in L. wallichii and Angelica sinensis (Oliv.) Diels (A. sinensis). The present study was carried out to examine the antiinflammatory effect and to elucidate the mode of the effect of TMP and FA. Both compounds significantly inhibited the edema induced by carrageenin, the increase of the dye leakage induced by acetic acid and the granuloma formation induced by cotton pellet. And also, TMP and FA inhibited the number of writhes induced by acetic acid. From these results, it is suggested that both compounds have the antiinflammatory effect and the analgesic effect, and both compounds exert an antiinflammatory effect at the early and the late stages of processes in the inflammatory pathology.
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The aleuron layer of wheat bran contains phytoprotectants that have antioxidative and anti-inflammatory potential, and anticarcinogenic activities in rodent animal models of colon and skin cancer.
“The aleuron layer of wheat bran contains a number of phytoprotectants (i.e., ferulic acid, alkylresorcinols, apigenin, lignans, and phytic acid), which have antioxidative and anti-inflammatory potential, and anticarcinogenic activities in rodent animal models of colon and skin cancer (56–59).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [57]
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- Authors
- OZAKI, Y.
- Affiliations
- National Institute of Health Sciences (JP)
- Corresponding author
- OZAKI, Yukihiro
- ORCID
- OZAKI, Yukihiro
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1992
- Volume
- 40
- Issue
- 4
- Pages
- 954-956
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2089881428
- Cited by
- 109
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 10
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Keywords
- tetramethylpyrazine, ferulic acid, anti-inflammatory activity, analgesic effect, Ligusticum wallichii, Angelica sinensis, carrageenan-induced edema, acetic acid-induced writhing, cotton pellet granuloma, dye leakage
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Coumaric Acids, Male, Medicine, Chinese Traditional, Mice, Inbred Strains, Pyrazines, Rats, Inbred Strains, Mice, Rats
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