Memory Enhancing Activity of Abana®: An Indian Ayurvedic Poly-Herbal Formulation
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The present study was aimed at investigating the effects of Abana, an Ayurvedic herbomineral preparation on memory and brain cholinesterase activity in mice. Drug Abana was administered orally in three doses (50, 100 and 200 mg/kg) for fifteen days to different groups of young and aged mice. Elevated plus maze and passive avoidance apparatus served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing- induced amnesia served as the interoceptive behavioral models. Brain cholinesterase activity was also estimated. Abana (50, 100 and 200 mg/kg, orally (p.o.)) produced a dose-dependent improvement in memory scores of young and aged mice. Furthermore, it reversed the amnesia induced by scopolamine (0.4mg/kg, intraperitoneally (i.p.)) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was reduced by Abana administered orally for 15 days. It may prove to be a useful remedy for the management of Alzheimer's disease.
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Acute oral administration of Abana in mice did not cause any toxicity up to the dose of 2000 mg/kg.
“Acute oral administration of Abana in mice did not cause any toxicity up to the dose of 2000 mg/kg [261].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [261]
Abana reduced the brain AChE activity in a dose dependent manner.
“Abana reduced the brain AChE activity in a dose dependent manner.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [261]
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References 63 · Cited by 31
Research works printed but not linked: 1
- Ecobichon, D. J. (1997) The basis of toxicology test- ing. CRC Press, New York.
- Authors
- Parle, M., & Vasudevan, M.
- Affiliations
- Guru Jambheshwar University of Science and Technology (IN)
- Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology
- Venue
- Journal of Health Science
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2007
- Volume
- 53
- Issue
- 1
- Pages
- 43-52
- ISSN
- 0013-273X (ISSN-L)
- 1344-9702
- 1347-5207
- OpenAlex
- W2106561300
- Cited by
- 31
- References
- 63
- Citations by year
- 2026: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Eisei kagaku (publishedVersion)
- Funders
- Guru Jambheshwar University of Science and Technology
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- Abana, memory enhancement, brain cholinesterase activity, scopolamine-induced amnesia, diazepam-induced amnesia, age-related memory impairment, Alzheimer's disease, polyherbal medicine, elevated plus maze, passive avoidance
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