Transient oliguria with renal tubular dysfunction after a 90 km running race
Abstract
In the course of a 19-d study of renal function in five ultramarathon runners, before, during and after a 90 km race, one runner developed transient oliguria with renal tubular dysfunction and anuria during and immediately after the race. Other features of the renal failure were an 84-fold increase in urine beta 2-microglobulin excretion (from 0.19 to 16.0 micrograms.min-1) and a much smaller increase in urine total protein excretion (from 0.07 to 0.18 mg.min-1) during the post-race period. Post-race creatinine clearance remained below pre-race levels throughout the study, varying between 42.8 and 72.9 ml.min-1, in contrast to the post-race 49% increase in the remaining runners (from 138.1 +/- 12.9 to 205.5 +/- 59.9 ml.min-1). Osmolal clearance also remained low (0.31 to 0.98 ml.min-1) compared with the pre-race values (1.46 +/- 0.02 ml.min-1), as did the urine flow rates (0.11 to 0.18 ml.min-1) compared with the pre-race values (0.34 +/- 0.02 ml.min-1). This renal dysfunction persisted despite the patient receiving 2 l of intravenous fluids immediately after the race and probably resulted from fluid restriction during the race. There was full recovery of renal function 1 yr later when the subject again ran the Comrades Marathon.
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Frequent prophylactic use of NSAIDs is associated with increased risk of renal side-effects.
“Frequent prophylactic use of NSAIDs is also associated with increased risk of renal side-effects [192, 193], and concern has been expressed about a possible causative role of NSAIDs on exercise-induced hyponatremia [194].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [193]
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Influential
- Authors
- IRVING, R. A., NOAKES, T. D., RAINE, R. I., & VAN ZYL SMIT, R.
- Affiliations
- University of Cape Town (ZA)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1990-12
- Volume
- 22
- Issue
- 6
- Pages
- 756
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1991776730
- Cited by
- 41
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2019: 4 · 2018: 4 · 2017: 5 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- renal tubular dysfunction, ultramarathon, anuria, urinary protein excretion, creatinine clearance, osmolal clearance, intravenous fluid therapy
- MeSH terms
- Adult, Analysis of Variance, beta 2-Microglobulin, Female, Glomerular Filtration Rate, Humans, Kidney Tubules, Male, Oliguria, Physical Endurance, Proteinuria, Running
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