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Cited by 18Cardiovascular and exercise physiologyMusculoskeletal pain and rehabilitationSports Performance and Training

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Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial

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AMPOMAH, KWASI, AMANO, SHINICHI, WAGES, NATHAN P., VOLZ, LAUREN, CLIFT, RACHEL, LUDIN, ARIMI FITRI MAT, NAKAZAWA, MASATO, LAW, TIMOTHY D., MANINI, TODD M., THOMAS, JAMES S., RUSS, DAVID W., CLARK, BRIAN C.·2019·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000001984PMC PMC6697223
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Abstract

Purpose: The goal of this trial was to determine whether low-load blood flow–restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in people with recurrent low back pain (LBP). We also investigated the direct effects of BFR exercise in the appendicular muscles. Methods: Thirty-two adults with recurrent, nonspecific LBP were randomized into two groups: Appendicular BFR exercise (BFR exercise) or control exercise (CON exercise). All participants trained (two times per week) for 10 wk, with a 12-wk follow-up. Participants performed three sets of leg extension (LE), plantar flexion (PF), and elbow flexion (EF) exercises followed by low-load TE exercise without BFR. Outcome measures included magnetic resonance imaging–derived muscle size (quadriceps and TE), strength (LE, PF, EF, and TE), and endurance (LE and TE). Results: There was no evidence for a cross-transfer of effect to the TE. There was also no statistically significant enhancement of limb skeletal muscle size or function of BFR relative to CON exercise at any time point; though, moderate effect sizes for BFR exercise were observed for enhanced muscle size and strength in the leg extensors. Conclusions: Low-load BFR exercise of the appendicular muscles did not result in a cross-transfer of effect to the TE musculature. There was also no significant benefit of low-load BFR exercise on the appendicular muscle size and function, suggesting no benefit from low-load BFR exercise in adults with recurrent, nonspecific LBP.

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Metadata

Authors
AMPOMAH, K., AMANO, S., WAGES, N. P., VOLZ, L., CLIFT, R., LUDIN, A. F. M., NAKAZAWA, M., LAW, T. D., MANINI, T. M., THOMAS, J. S., RUSS, D. W., & CLARK, B. C.
Affiliations
  • Ohio University (US)
  • University of Florida (US)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2019-03-22
Volume
51
Issue
9
Pages
1817-1827
ISSN
  • 0195-9131 (ISSN-L)
  • 1530-0315
DOI
10.1249/mss.0000000000001984
PMC
PMC6697223
OpenAlex
W2932707089
Cited by
18
References
4
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1
FWCI
2.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR063909)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
blood flow restriction, low-load exercise, trunk extensors, non-specific low back pain, muscle size, muscle strength, muscular endurance, leg extension, plantar flexion, elbow flexion
MeSH terms
Adult, Arm, Exercise Therapy, Female, Humans, Leg, Magnetic Resonance Imaging, Male, Recurrence, Regional Blood Flow, Single-Blind Method, Low Back Pain, Muscle, Skeletal, Muscle Strength, Resistance Training, Young Adult

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