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Cited by 143Dietary Effects on HealthNutritional Studies and DietExercise and Physiological Responses

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors

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MORO, TATIANA, TINSLEY, GRANT, PACELLI, FRANCESCO Q., MARCOLIN, GIUSEPPE, BIANCO, ANTONINO, PAOLI, ANTONIO·2021·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000002738PMC PMC10115489
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Abstract

Introduction: Recently, a modified intermittent fasting protocol was demonstrated to be able to maintain muscle mass and strength, decrease fat mass, and improve some inflammation and cardiovascular risk factors in healthy resistance-trained males after 2 months. The present study sought to investigate the long-term effects on these parameters. Methods: The experiment was a single-blind randomized study. Twenty healthy subjects were enrolled and underwent 12 months of either a time-restricted eating (TRE) diet or a normal diet (ND) protocol, along with resistance training. In the TRE protocol, subjects consumed their energy needs in three meals during an 8-h period of time each day (1 pm , 4 pm , and 8 pm ). Subjects in the ND group also had three meals, which were consumed at 8 am , 1 pm , and 8 pm . Groups were matched for kilocalories consumed and macronutrient distribution at baseline. Results: After 12 months of TRE, body mass, fat mass, insulin-like growth factor 1, and testosterone were significantly lower compared with ND. Moreover, inflammatory markers (interleukin 6, interleukin 1β, and tumor necrosis factor α), insulin sensitivity (fasting glucose, insulin, and homeostatic model assessment for insulin resistance index), and lipid profile (cholesterol, HDL, and LDL) significantly improved after TRE compared with ND. Finally, subjects in TRE spontaneously decreased their daily energy intake, whereas those in ND maintained their starting kilocalories per day. No adverse events were reported. Conclusions: Our results suggest that long-term TRE combined with a resistance training program is feasible, safe, and effective in reducing inflammatory markers and risk factors related to cardiovascular and metabolic diseases.

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Metadata

Authors
MORO, T., TINSLEY, G., PACELLI, F. Q., MARCOLIN, G., BIANCO, A., & PAOLI, A.
Affiliations
  • University of Padua (IT)
  • Texas Tech University (US)
  • Department of Biomedical Sciences, University of Padova, Padova, ITALY
  • University of Palermo (IT)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021-07-09
Volume
53
Issue
12
Pages
2577-2585
ISSN
  • 0195-9131 (ISSN-L)
  • 1530-0315
DOI
10.1249/mss.0000000000002738
PMC
PMC10115489
OpenAlex
W3184698953
Cited by
134
References
52
Citations by year
2026: 25 · 2025: 37 · 2024: 36 · 2023: 19 · 2022: 17
FWCI
11.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
time-restricted eating, intermittent fasting, resistance training, inflammation, cardiometabolic risk factors, insulin resistance, insulin sensitivity, lipid profile, body composition, fat mass, testosterone, insulin-like growth factor I, energy intake, interleukin-6, TNF-α, IL-1β, long-term dietary intervention
MeSH terms
Cardiometabolic Risk Factors, Energy Intake, Fasting, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Male, Body Mass Index, Single-Blind Method, Adiposity, Resistance Training

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