Diet and feeding pattern affect the diurnal dynamics of the gut microbiome
Open accessAbstract
The gut microbiome and daily feeding/fasting cycle influence host metabolism and contribute to obesity and metabolic diseases. However, fundamental characteristics of this relationship between the feeding/fasting cycle and the gut microbiome are unknown. Our studies show that the gut microbiome is highly dynamic, exhibiting daily cyclical fluctuations in composition. Diet-induced obesity dampens the daily feeding/fasting rhythm and diminishes many of these cyclical fluctuations. Time-restricted feeding (TRF), in which feeding is consolidated to the nocturnal phase, partially restores these cyclical fluctuations. Furthermore, TRF, which protects against obesity and metabolic diseases, affects bacteria shown to influence host metabolism. Cyclical changes in the gut microbiome from feeding/fasting rhythms contribute to the diversity of gut microflora and likely represent a mechanism by which the gut microbiome affects host metabolism. Thus, feeding pattern and time of harvest, in addition to diet, are important parameters when assessing the microbiome's contribution to host metabolism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Changes in intestinal pH and nutrient and secondary metabolite availability are expected to play a role in host metabolism.
“Collectively, changes in the intestinal pH and nutrient and secondary metabolite availability are expected to play a role in host metabolism [79].”
Time-restricted feeding in mice and repeated prolonged cycles of feeding and withholding food in dogs cause a change in the overall gut microbiome that appears driven by changes in the abundance of species that differ by their preferred fermentable substrates.
“Time-restricted feeding in mice [79] and repeated prolonged cycles of feeding and withholding food in dogs [80] have all been shown to cause a change in the overall gut microbiome that appears to be driven by changes in the abundance of species that differ by their preferred fermentable substrates (e.g., host-vs. diet-derived glycans).”
Meal timing and nutrient composition were kept constant across the two study conditions.
“As meal timing and nutrient composition can influence the gut microbiota [30], these were kept constant across the two study conditions.”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [30]
The gut microbiota exhibits a circadian rhythm in mice and humans.
“There is currently some evidence in both mice and humans that the gut microbiota exhibits a circadian rhythm [28], [29], [30]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Million, M., Maraninchi, M., Henry, M., Armougom, F., Richet, H., Carrieri, P., Valéro, R., Raccah, D., Vialettes, B., & Raoult, D. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.153 · Cited by 660 · see citing works
RetractedMillion, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., Vialettes, B., & Raoult, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.20 · Cited by 362 · see citing works
Retractedvegan: Community Ecology Package
Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R., O’Hara, R. B., Sólymos, P., Stevens, M. H. H., Szöcs, E., et al. (2001) · doi:10.32614/cran.package.vegan · Cited by 27,099 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works
Jost, L. (2006) · Oikos · doi:10.1111/j.2006.0030-1299.14714.x · Cited by 4,669 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
The Long-Term Stability of the Human Gut Microbiota
Faith, J. J., Guruge, J. L., Charbonneau, M., Subramanian, S., Seedorf, H., Goodman, A. L., Clemente, J. C., Knight, R., Heath, A. C., Leibel, R. L., et al. (2013) · Science · doi:10.1126/science.1237439 · Cited by 2,058 · see citing works
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
Self-citationHuman gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Measuring beta diversity for presence–absence data
Koleff, P., Gaston, K. J., & Lennon, J. J. (2003) · Journal of Animal Ecology · doi:10.1046/j.1365-2656.2003.00710.x · Cited by 1,787 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works
Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M. W., & Milgram, K. E. (2009) · Analytical Chemistry · doi:10.1021/ac901536h · Cited by 1,315 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087 · see citing works
Murphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 942 · see citing works
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779 · see citing works
Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705 · see citing works
Raman, M., Ahmed, I., Gillevet, P. M., Probert, C. S., Ratcliffe, N. M., Smith, S., Greenwood, R., Sikaroodi, M., Lam, V., Crotty, P., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.015 · Cited by 672 · see citing works
WebMGA: a customizable web server for fast metagenomic sequence analysis
Wu, S., Zhu, Z., Fu, L., Niu, B., & Li, W. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-444 · Cited by 612 · see citing works
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Joyce, S. A., MacSharry, J., Casey, P. G., Kinsella, M., Murphy, E. F., Shanahan, F., Hill, C., & Gahan, C. G. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323599111 · Cited by 604 · see citing works
Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544 · see citing works
Circadian disorganization alters intestinal microbiota
Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097500 · Cited by 439 · see citing works
FXR signaling in the enterohepatic system
Matsubara, T., Li, F., & Gonzalez, F. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.004 · Cited by 383 · see citing works
Padmanabhan, P., Grosse, J., Asad, A. B. M. A., Radda, G. K., & Golay, X. (2013) · EJNMMI Research · doi:10.1186/2191-219x-3-60 · Cited by 188 · see citing works
Bile acids: analysis in biological fluids and tissues
Griffiths, W. J., & Sjövall, J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r001941-jlr200 · Cited by 178 · see citing works
Biological clocks and the digestive system
Scheving, L. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.9305 · Cited by 130 · see citing works
Zhang, Y.-K. J., Guo, G. L., & Klaassen, C. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016683 · Cited by 122 · see citing works
Zarrinpar, A., & Loomba, R. S. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12084 · Cited by 102 · see citing works
Self-citationPER1 Phosphorylation Specifies Feeding Rhythm in Mice
Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.032 · Cited by 73 · see citing works
Self-citationGilardi, F., Mitro, N., Godio, C., Scotti, E., Caruso, D., Crestani, M., & Fabiani, E. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.08.003 · Cited by 72 · see citing works
Microbial Biotransformations of Bile Acids as Detected by Electrospray Mass Spectrometry
Hagey, L. R., & Krasowski, M. D. (2013) · Advances in Nutrition · doi:10.3945/an.112.003061 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The microbiome and innate immunity
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
The two‐process model of sleep regulation: a reappraisal
Borbély, A. A., Daan, S., Wirz‐Justice, A., & Deboer, T. (2016) · Journal of Sleep Research · doi:10.1111/jsr.12371 · Cited by 1,577 · see citing works
Sutton, E. F., Beyl, R., Early, K. S., Cefalu, W. T., Ravussin, E., & Peterson, C. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.010 · Cited by 1,531 · see citing works
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092 · see citing works
Self-citationFasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works
Self-citationLeone, V., Gibbons, S. M., Martinez, K., Hutchison, A. L., Huang, E. Y., Cham, C. M., Pierre, J. F., Heneghan, A. F., Nadimpalli, A., Hubert, N., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.006 · Cited by 908 · see citing works
Gill, S., & Panda, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.005 · Cited by 894 · see citing works
Self-citationDiet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879 · see citing works
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
Thaiss, C. A., Levy, M., Korem, T., Dohnalová, L., Shapiro, H., Jaitin, D. A., David, E., Winter, D. R., Gury-BenAri, M., Tatirovsky, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.003 · Cited by 870 · see citing works
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works
Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration
Leeming, E. R., Johnson, A. J., Spector, T. D., & Le Roy, C. I. (2019) · Nutrients · doi:10.3390/nu11122862 · Cited by 817 · see citing works
Metabolic Effects of Intermittent Fasting
Patterson, R. E., & Sears, D. D. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064634 · Cited by 810 · see citing works
Jamshed, H., Beyl, R., Della Manna, D., Yang, E., Ravussin, E., & Peterson, C. (2019) · Nutrients · doi:10.3390/nu11061234 · Cited by 664 · see citing works
The gut microbiome and metabolic syndrome
Dabke, K., Hendrick, G., & Devkota, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129194 · Cited by 663 · see citing works
Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313432 · Cited by 618 · see citing works
Crosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578 · see citing works
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 552 · see citing works
Zarrinpar, A., Chaix, A., Xu, Z. Z., Chang, M. W., Marotz, C. A., Saghatelian, A., Knight, R., & Panda, S. (2018) · Nature Communications · doi:10.1038/s41467-018-05336-9 · Cited by 546 · see citing works
Self-citationThe obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 535 · see citing works
Ussar, S., Griffin, N. W., Bézy, O., Fujisaka, S., Vienberg, S. G., Softic, S., Deng, L., Bry, L., Gordon, J. I., & Kahn, C. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.007 · Cited by 529 · see citing works
Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens
Kers, J. G., Velkers, F. C., Fischer, E. A. J., Hermes, G. D. A., Stegeman, A., & Smidt, H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00235 · Cited by 522 · see citing works
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works
The Human Microbiome and Obesity: Moving beyond Associations
Maruvada, P., Leone, V., Kaplan, L. M., & Chang, E. B. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.005 · Cited by 468 · see citing works
Regional Diversity of the Gastrointestinal Microbiome
Martinez, K., Leone, V., & Chang, E. B. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.011 · Cited by 466 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices
Tang, Q., Jin, G., Wang, G., Liu, T., Liu, X., Wang, B., & Cao, H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00151 · Cited by 461 · see citing works
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour
Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403 · see citing works
Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases
Chaix, A., Manoogian, E. N. C., Melkani, G. C., & Panda, S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124320 · Cited by 402 · see citing works
Self-citationMicrobiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes
Johnson, E. L., Heaver, S. L., Walters, W. A., & Ley, R. E. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1492-2 · Cited by 389 · see citing works
Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer
Bishehsari, F., Voigt, R. M., & Keshavarzian, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00427-4 · Cited by 378 · see citing works
Microbial nutrient niches in the gut
Pereira, F. C., & Berry, D. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13659 · Cited by 365 · see citing works
The Role of the Gut Microbiota in the Relationship Between Diet and Human Health
Perler, B. K., Friedman, E. S., & Wu, G. D. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031522-092054 · Cited by 385 · see citing works
Time-restricted eating for the prevention and management of metabolic diseases
Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344 · see citing works
Self-citationAdvancing functional and translational microbiome research using meta-omics approaches
Zhang, X., Li, L., Butcher, J., Stintzi, A., & Figeys, D. (2019) · Microbiome · doi:10.1186/s40168-019-0767-6 · Cited by 343 · see citing works
Rynders, C. A., Thomas, E. A., Zaman, A., Pan, Z., Catenacci, V. A., & Melanson, E. L. (2019) · Nutrients · doi:10.3390/nu11102442 · Cited by 339 · see citing works
Circadian rhythms, time-restricted feeding, and healthy aging
Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330 · see citing works
Self-citationThe neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
“fluctuations in composition and in the production of key metabolic mediators (Leone et al., 2015; Liang et al., 2015; Thaiss et al., 2014; Zarrinpar et al., 2014).”
BackgroundBenedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., & Cedernaes, J. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.003 · Cited by 324 · see citing works
“As meal timing and nutrient composition can influence the gut microbiota [30], these were kept constant across the two study conditions.”
BackgroundBreton, J., Tennoune, N., Lucas, N., Francois, M., Legrand, R., Jacquemot, J., Goichon, A., Guérin, C., Peltier, J., Pestel-Caron, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.017 · Cited by 321 · see citing works
Environmental fluctuations and their effects on microbial communities, populations and individuals
Nguyen, J., Lara‐Gutiérrez, J., & Stocker, R. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa068 · Cited by 324 · see citing works
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism
Link, J. C., & Reue, K. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064827 · Cited by 293 · see citing works
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 294 · see citing works
Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F. (2019) · Microorganisms · doi:10.3390/microorganisms7020041 · Cited by 285 · see citing works
Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes
Reitmeier, S., Kießling, S., Clavel, T., List, M., Almeida, E. L., Ghosh, T. S., Neuhaus, K., Grallert, H., Linseisen, J., Skurk, T., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.004 · Cited by 274 · see citing works
Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Xie, Z., Sun, Y., Ye, Y., Hu, D., Zhang, H., He, Z., Zhao, H., Yang, H., & Mao, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-28662-5 · Cited by 276 · see citing works
Microbiota succession throughout life from the cradle to the grave
Martino, C., Dilmore, A. H., Burcham, Z. M., Metcalf, J. L., Jeste, D., & Knight, R. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00768-z · Cited by 275 · see citing works
Circadian rhythm and the gut microbiome
Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.002 · Cited by 274 · see citing works
The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Weger, B. D., Gobet, C., Yeung, J., Martin, E., Jimenez, S., Betrisey, B., Foata, F., Berger, B., Balvay, A., Foussier, A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.023 · Cited by 269 · see citing works
Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity
Paulose, J. K., Wright, J. M., Patel, A., & Cassone, V. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146643 · Cited by 264 · see citing works
Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis
Liang, S., Wu, X., & Jin, F. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00033 · Cited by 269 · see citing works
Daily eating patterns and their impact on health and disease
Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263 · see citing works
Self-citationPerfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary
Haspel, J. A., Anafi, R. C., Brown, M. K., Cermakian, N., Depner, C. M., Desplats, P., Gelman, A. E., Haack, M., Jelić, S., Kim, B., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.131487 · Cited by 250 · see citing works
Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model
Lin, H., An, Y., Tang, H., & Wang, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00249 · Cited by 235 · see citing works
Circadian rhythms of liver physiology and disease: experimental and clinical evidence
Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 231 · see citing works
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Brooks, J. F., Behrendt, C. L., Ruhn, K. A., Lee, S., Raj, P., Takahashi, J. S., & Hooper, L. V. (2021) · Cell · doi:10.1016/j.cell.2021.07.001 · Cited by 230 · see citing works
The gut microbiota and gastrointestinal surgery
Guyton, K. L., & Alverdy, J. C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.139 · Cited by 225 · see citing works
Nutrition and the circadian system
Potter, G. D. M., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · British Journal of Nutrition · doi:10.1017/s0007114516002117 · Cited by 220 · see citing works
Influence of Early Life, Diet, and the Environment on the Microbiome
Dong, T. S., & Gupta, A. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.067 · Cited by 216 · see citing works
Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation
Regmi, P., & Heilbronn, L. K. (2020) · iScience · doi:10.1016/j.isci.2020.101161 · Cited by 222 · see citing works
Vandeputte, D., Commer, L. D., Tito, R. Y., Kathagen, G., Sabino, J., Vermeire, S., Faust, K., & Raes, J. (2021) · Nature Communications · doi:10.1038/s41467-021-27098-7 · Cited by 218 · see citing works
Analyses of Intestinal Microbiota: Culture versus Sequencing: Figure 1
Hiergeist, A., Gläsner, J., Reischl, U., & Gessner, A. (2015) · ILAR Journal · doi:10.1093/ilar/ilv017 · Cited by 214 · see citing works
Caloric restriction disrupts the microbiota and colonization resistance
von Schwartzenberg, R. J., Bisanz, J. E., Lyalina, S., Spanogiannopoulos, P., Ang, Q. Y., Cai, J., Dickmann, S., Friedrich, M., Liu, S.-Y., Collins, S. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03663-4 · Cited by 211 · see citing works
The functionality of the gastrointestinal microbiome in non-human animals
Hanning, I. B., & Sanchez, S. D. (2015) · Microbiome · doi:10.1186/s40168-015-0113-6 · Cited by 201 · see citing works
Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids
Klaassen, C. D., & Cui, J. Y. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065698 · Cited by 208 · see citing works
Kaczmarek, J. L., Musaad, S. M., & Holscher, H. D. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156380 · Cited by 200 · see citing works
Wu, Q., Liang, X., Wang, K., Lin, J., Wang, X., Wang, P., Zhang, Y., Nie, Q., Liu, H., Zhang, Z., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.007 · Cited by 201 · see citing works
When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
The Effects of Intermittent Fasting on Brain and Cognitive Function
Gudden, J., Vásquez, A. A., & Bloemendaal, M. (2021) · Nutrients · doi:10.3390/nu13093166 · Cited by 204 · see citing works
Zhou, Z.-L., Jia, X.-B., Sun, M.-F., Zhu, Y.-L., Qiao, C.-M., Zhang, B.-P., Zhao, L.-P., Yang, Q., Cui, C., Chen, X., et al. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00719-2 · Cited by 195 · see citing works
Sharpton, S. R., Schnabl, B., Knight, R., & Loomba, R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.010 · Cited by 194 · see citing works
Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism
Choi, H., Rao, M. C., & Chang, E. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00452-2 · Cited by 192 · see citing works
Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis
Tuganbaev, T., Mor, U., Bashiardes, S., Liwinski, T., Nobs, S. P., Leshem, A., Dori-Bachash, M., Thaiss, C. A., Pinker, E. Y., Ratiner, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.027 · Cited by 192 · see citing works
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
Bokoliya, S. C., Dorsett, Y., Panier, H. A., & Zhou, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.711055 · Cited by 186 · see citing works
Gut Microbiota: The Brain Peacekeeper
Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188 · see citing works
Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms
Grandner, M. A., Seixas, A. A., Shetty, S., & Shenoy, S. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0805-8 · Cited by 188 · see citing works
From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease
McKenney, P. T., & Pamer, E. G. (2015) · Cell · doi:10.1016/j.cell.2015.11.032 · Cited by 182 · see citing works
Disturbances of sleep and circadian rhythms: novel risk factors for obesity
Broussard, J. L., & Cauter, E. V. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000276 · Cited by 183 · see citing works
Gut microbiota regulates stress responsivity via the circadian system
Tofani, G. S. S., Leigh, S., Gheorghe, C. E., Bastiaanssen, T. F. S., Wilmes, L., Sen, P., Clarke, G. A., & Cryan, J. F. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.003 · Cited by 188 · see citing works
Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178 · see citing works
The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis
Heddes, M., Altaha, B., Niu, Y., Reitmeier, S., Kleigrewe, K., Haller, D., & Kießling, S. (2022) · Nature Communications · doi:10.1038/s41467-022-33609-x · Cited by 177 · see citing works
Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism
Frazier, K., & Chang, E. B. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.013 · Cited by 169 · see citing works
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173 · see citing works
Self-citationCircadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 172 · see citing works
Self-citationEndocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
Collado, M. C., Engen, P. A., Bandín, C., Cabrera‐Rubio, R., Voigt, R. M., Green, S. J., Naqib, A., Keshavarzian, A., Scheer, F. A. J. L., & Garaulet, M. (2018) · The FASEB Journal · doi:10.1096/fj.201700697rr · Cited by 168 · see citing works
Pellegrini, M., Cioffi, I., Evangelista, A., Ponzo, V., Goitre, I., Ciccone, G., Ghigo, E., & Bo, S. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09524-w · Cited by 168 · see citing works
The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome
Finlay, B. B., Amato, K. R., Azad, M. B., Blaser, M. J., Bosch, T. C. G., Chu, H., Domínguez-Bello, M. G., Ehrlich, S. D., Elinav, E., Geva‐Zatorsky, N., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010217118 · Cited by 164 · see citing works
Circadian Rhythms, Disease and Chronotherapy
Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 166 · see citing works
Microbiota and sleep: awakening the gut feeling
Sen, P., Molinero-Perez, A., O’Riordan, K. J., McCafferty, C. P., O’Halloran, K. D., & Cryan, J. F. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.07.004 · Cited by 162 · see citing works
Circadian clocks in the digestive system
Segers, A., & Depoortere, I. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00401-5 · Cited by 160 · see citing works
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet
Lopez, D. E. G., Lashinger, L. M., Weinstock, G. M., & Bray, M. S. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.015 · Cited by 161 · see citing works
Microbial diversity — exploration of natural ecosystems and microbiomes
Gibbons, S. M., & Gilbert, J. A. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.10.003 · Cited by 158 · see citing works
Murakami, M., Tognini, P., Liu, Y., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2016) · EMBO Reports · doi:10.15252/embr.201642463 · Cited by 155 · see citing works
Li, H., Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., & Gitai, Z. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0199-2 · Cited by 157 · see citing works
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
Zwighaft, Z., Aviram, R., Shalev, M., Rousso-Noori, L., Kraut‐Cohen, J., Golik, M., Brandis, A. S., Reinke, H., Aharoni, A., Kahana, C., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.011 · Cited by 159 · see citing works
- Authors
- Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- J. Craig Venter Institute (US)
- Corresponding author
- Panda, Satchidananda
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 20
- Issue
- 6
- Pages
- 1006-1017
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4255146
- OpenAlex
- W2016539998
- Cited by
- 926
- References
- 50
- Citations by year
- 2026: 76 · 2025: 89 · 2024: 79 · 2023: 103 · 2022: 125 · 2021: 141 · 2020: 82 · 2019: 63 · 2018: 51 · 2017: 42 · 2016: 43 · 2015: 30
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (KL2TR000099)
- National Eye Institute (P30EY019005)
- National Cancer Institute (P30CA014195)
- National Institute of General Medical Sciences (P50GM085764)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK080506, T32-DK07202, DK-097153, DK 091618, U24DK097153, R01DK091618, T32DK007202)
- National Center for Advancing Translational Sciences (KL2 TR00099)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, feeding-fasting cycle, time-restricted feeding, diet-induced obesity, diurnal cycle, microbiome dynamics, host metabolism, metabolic disorders, microbiome diversity
- MeSH terms
- Animals, Diet, Feeding Behavior, Male, Mice, Inbred C57BL, Obesity, Gastrointestinal Tract, Mice, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review