Highly Purified Eicosapentaenoic Acid May Increase Low-Density Lipoprotein Particle Size by Improving Triglyceride Metabolism in Patients With Hypertriglyceridemia
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BACKGROUND: The purpose of this study was to evaluate the effect of highly purified eicosapentaenoic acid (EPA) in increasing low-density lipoprotein (LDL) particle size, as one of the possible mechanisms by which intake of EPA may prevent coronary events. METHODS AND RESULTS: Hypertriglyceridemic subjects were randomly assigned to a control group (n=72) or an EPA group (n=72; EPA regimen 1,800mg/day for 6 months). In the EPA group, the serum LDL-cholesterol and high-density lipoprotein cholesterol levels remained unchanged, but there was a significant increase in LDL particle size based on LDL-relative mobility measured on lipoprotein polyacrylamide-gel electrophoresis, and a significant decrease in serum triglyceride-rich lipoproteins (TRLs) level. None of these changes were observed in the control group. After adjustments for coronary risk factors, multivariate logistic regression analysis identified elevation of serum EPA-related markers (6-month EPA, 6-month EPA/arachidonic acid [AA] ratio, change in [Δ] EPA, and EPA/AA), and treatment with statins and EPA as independent variables associated with increase in LDL particle size. Negative correlations were found between ΔTRLs and ΔLDL particle size, suggesting that improvement in triglyceride metabolism was associated with an increase in LDL particle size. CONCLUSIONS: EPA increases LDL particle size by improving triglyceride metabolism; and serum EPA level and EPA/AA ratio after EPA treatment may be useful markers of increased LDL particle size.
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A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles.
“A consistent finding is an increase in mean LDL particle size, with a resulting shift towards those classified as large, rather than small, LDL particles [7, 45, 51–54].”
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References 34 · Cited by 31
Research works printed but not linked: 3
- Matsuzaki M, Yokoyama M, Saito Y, Origasa H, Ishikawa Y, Oikawa S, et al. Incremental effects of eicosapentaenoic acid on cardiovascu- lar events in statin-treated patients with coronary artery disease. Circ J 2009; 73: 1283 -1290.
- Mishima Y, Ando M, Kuyama F, Ishioka T, Kihata M. A simple method for identifying particle size of low-density lipoprotein using PAG electrophoresis: Comparison between LipoPhor and Lipoprint LDL systems. J Jpn Atherscler Soc 1997; 25: 67 -70.
- Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, Ginsberg HN, et al. American Heart Association Clinical Lipidology, Throm- bosis, and Prevention Committee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease. Triglycerides and cardiovas- cular disease: A scientific statement from the American Heart Asso- ciation. Circulation 2011; 123: 2292 -2333.
- Authors
- Tani, S., Nagao, K., Matsumoto, M., & Hirayama, A.
- Affiliations
- Nihon University (JP)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2013
- Volume
- 77
- Issue
- 9
- Pages
- 2349-2357
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W1979880368
- Cited by
- 31
- References
- 34
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23590757)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- eicosapentaenoic acid, LDL particle size, hypertriglyceridemia, triglyceride metabolism, triglyceride-rich lipoproteins, EPA/AA ratio, omega-3 fatty acids, coronary heart disease prevention, statins
- MeSH terms
- Aged, Coronary Artery Disease, Female, Humans, Lipoproteins, LDL, Male, Middle Aged, Particle Size, Prospective Studies, Risk Factors, Triglycerides, Eicosapentaenoic Acid, Hypertriglyceridemia
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